Quantification of metallothionein-III in brain tissues using liquid chromatography tandem mass spectrometry

Metallothioneins (MTs) are crucial for metal ion homeostasis in mammalian cells. Specialized mass spectrometry methods have been developed to detect MTs in tissue extracts, though facile methods with scalable throughput are lacking. To improve analytical throughput and repeatability, we developed a...

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Veröffentlicht in:	Analytical biochemistry 2021-10, Vol.630, p.114326-114326, Article 114326
Hauptverfasser:	Gunn, Adam P., McLean, Catriona A., Crouch, Peter J., Roberts, Blaine R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer's disease Brain Brain - pathology Chromatography, Liquid Cohort Studies Female Humans Male Metallothionein Metallothionein 3 - analysis Proteomics Quantitative Selected reaction monitoring (SRM) Tandem Mass Spectrometry
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