Advances in pulmonary drug delivery targeting microbial biofilms in respiratory diseases
The increasing burden of respiratory diseases caused by microbial infections poses an immense threat to global health. This review focuses on the various types of biofilms that affect the respiratory system and cause pulmonary infections, specifically bacterial biofilms. The article also sheds light...
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| Veröffentlicht in: | Nanomedicine (London, England) England), 2021-09, Vol.16 (21), p.1905-1923 |
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| container_title | Nanomedicine (London, England) |
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| creator | Sharma, Ankur Kumar, Dhruv Dahiya, Kajal Hawthorne, Susan Jha, Saurabh Kumar Jha, Niraj Kumar Nand, Parma Girgis, Samuel Raj, Sibi Srivastava, Rashi Goswami, Vineet Kumar Gregoriou, Yiota El-Zahaby, Sally A Ojha, Shreesh Dureja, Harish Gupta, Gaurav Singh, Sachin Chellappan, Dinesh Kumar Dua, Kamal |
| description | The increasing burden of respiratory diseases caused by microbial infections poses an immense threat to global health. This review focuses on the various types of biofilms that affect the respiratory system and cause pulmonary infections, specifically bacterial biofilms. The article also sheds light on the current strategies employed for the treatment of such pulmonary infection-causing biofilms. The potential of nanocarriers as an effective treatment modality for pulmonary infections is discussed, along with the challenges faced during treatment and the measures that may be implemented to overcome these. Understanding the primary approaches of treatment against biofilm infection and applications of drug-delivery systems that employ nanoparticle-based approaches in the disruption of biofilms are of utmost interest which may guide scientists to explore the vistas of biofilm research while determining suitable treatment modalities for pulmonary respiratory infections. |
| doi_str_mv | 10.2217/nnm-2021-0057 |
| format | Article |
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| ispartof | Nanomedicine (London, England), 2021-09, Vol.16 (21), p.1905-1923 |
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| source | PubMed Central |
| subjects | bacterial biofilm biofilm drug delivery nanocarriers pulmonary infection systemic therapy |
| title | Advances in pulmonary drug delivery targeting microbial biofilms in respiratory diseases |
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