Blocking MCT4 SUMOylation inhibits the growth of breast cancer cells

Monocarboxylate transporter 4 (MCT4) is highly expressed in various types of solid neoplasms including breast cancer (BC); however, the pro‐tumor functions underlying its increased expression have not been explained. Here, we examined the roles of posttranslational modifications to MCT4 in BC, parti...

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Veröffentlicht in:	Molecular carcinogenesis 2021-10, Vol.60 (10), p.702-714
Hauptverfasser:	Hu, Xiao, Liu, Zhanzhao, Duan, Xianxian, Han, Xiao, Yuan, Mengci, Liu, Lingyan, Xia, Xiaojun, Li, Ning, Qin, Junfang, Wang, Yue
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitumor activity Breast cancer breast cancer (BC) monocarboxylate transporter 4 (MCT4) Mutation Neoplasia posttranslational modifications (PTMs) SUMO protein SUMOylation Ubiquitin Ubiquitin-protein ligase Ubiquitination
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