Improved survival in children with HPS: Experience from two high volume liver transplant centers across continents
Background Severe HPS increases morbidity and mortality after LT in children. We reviewed the combined experience of LT for HPS in children from two LT centers in Europe and Asia. Methods All children with “proven” HPS as per ERS Task Force criteria (detailed in manuscript) who underwent LT were cat...
Gespeichert in:
| Veröffentlicht in: | Pediatric transplantation 2021-11, Vol.25 (7), p.e14088-n/a |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 7 |
| container_start_page | e14088 |
| container_title | Pediatric transplantation |
| container_volume | 25 |
| creator | Shanmugam, Naresh Hakeem, Abdul Rahman Valamparampil, Joseph J. Aldouri, Ahmed Bansal, Mehak Reddy, Mettu Srinivas Thiruchunapalli, Deepashree Vilca‐Melendez, Hector Baker, Alastair Dhawan, Anil Heaton, Nigel Rela, Mohamed Deep, Akash |
| description | Background
Severe HPS increases morbidity and mortality after LT in children. We reviewed the combined experience of LT for HPS in children from two LT centers in Europe and Asia.
Methods
All children with “proven” HPS as per ERS Task Force criteria (detailed in manuscript) who underwent LT were categorized into M (PaO2 ≥80 mmHg), Mo (PaO2 = 60–79 mmHg), S (50–59 mmHg), and VS (PaO2 |
| doi_str_mv | 10.1111/petr.14088 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2558452048</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2580691449</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3578-f6235fb2682ab93bb80f75145dbe36f798ac2d7f1bddb9b498ba4831d5134d983</originalsourceid><addsrcrecordid>eNp9kU9r3DAQxUVJaf60l36AIOilFJxIlmRLvYWwTQKBLun2bCRr3FWwZUeyvc23j3Y3ySGHzGWG4cdj3jyEvlJyRlOdDzCGM8qJlB_QEWVKZYzw4mA3lxmjPD9ExzHeE0ILLvkndMg4E7Qo5REKN90Q-hksjlOY3axb7Dyu1661ATzeuHGNr5d_fuLF_wGCA18DbkLf4XHT47X7t8Zz304d4NbNEPAYtI9Dq_2Ia_AjhIh1HfoYcd370fm0i5_Rx0a3Eb489xP099didXmd3f6-urm8uM1qJkqZNUXORGPyQubaKGaMJE0pKBfWACuaUkld57ZsqLHWKMOVNJpLRq2gjFsl2Qn6vtdNBh8miGPVuVhDm66DfopVLoTkIid8i357g973U_DpukRJUijKuUrUjz21cxSgqYbgOh0eK0qqbRLVNolql0SCT58lJ9OBfUVfXp8Augc2roXHd6Sq5WJ1txd9AlnqlQw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2580691449</pqid></control><display><type>article</type><title>Improved survival in children with HPS: Experience from two high volume liver transplant centers across continents</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Shanmugam, Naresh ; Hakeem, Abdul Rahman ; Valamparampil, Joseph J. ; Aldouri, Ahmed ; Bansal, Mehak ; Reddy, Mettu Srinivas ; Thiruchunapalli, Deepashree ; Vilca‐Melendez, Hector ; Baker, Alastair ; Dhawan, Anil ; Heaton, Nigel ; Rela, Mohamed ; Deep, Akash</creator><creatorcontrib>Shanmugam, Naresh ; Hakeem, Abdul Rahman ; Valamparampil, Joseph J. ; Aldouri, Ahmed ; Bansal, Mehak ; Reddy, Mettu Srinivas ; Thiruchunapalli, Deepashree ; Vilca‐Melendez, Hector ; Baker, Alastair ; Dhawan, Anil ; Heaton, Nigel ; Rela, Mohamed ; Deep, Akash</creatorcontrib><description>Background
Severe HPS increases morbidity and mortality after LT in children. We reviewed the combined experience of LT for HPS in children from two LT centers in Europe and Asia.
Methods
All children with “proven” HPS as per ERS Task Force criteria (detailed in manuscript) who underwent LT were categorized into M (PaO2 ≥80 mmHg), Mo (PaO2 = 60–79 mmHg), S (50–59 mmHg), and VS (PaO2 <50 mmHg) HPS, based on room air PaO2.
Results
Twenty‐four children with HPS underwent 25 LT (one re‐transplantation) at a median age of 8 years (IQR, 5–12), after a median duration of 8 (4–12) months following HPS diagnosis. Mechanical ventilation was required for a median of 3 (1.5–27) days after LT. Ten children had “S” post‐operative hypoxemia, requiring iNO for a median of 5 (6–27) days. “VS” category patients had significantly prolonged invasive ventilation (median 35 vs. 3 and 1.5 days; p = .008), ICU stay (median 39 vs. 8 and 8 days; p = .007), and hospital stay (64 vs. 26.5 and 23 days; p < .001) when compared to “S” and “M/Mo” groups, respectively. The need for pre‐transplant home oxygen therapy was the only factor predicting need for re‐intubation. Patient and graft survival at 32 (17–98) months were 100% and 95.8%. All children ultimately had complete resolution of HPS.
Conclusions
VS HPS is associated with longer duration of mechanical ventilation and hospital stay, which emphasizes the need for early LT in these children.</description><identifier>ISSN: 1397-3142</identifier><identifier>EISSN: 1399-3046</identifier><identifier>DOI: 10.1111/petr.14088</identifier><identifier>PMID: 34351678</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Child ; Child, Preschool ; Children ; failed extubation ; Female ; Graft Survival ; Hepatopulmonary Syndrome - mortality ; Hepatopulmonary Syndrome - surgery ; HPS ; Humans ; Hypoxemia ; Infant ; intrapulmonary vascular dilatation ; Intubation ; Liver Transplantation ; Liver transplants ; London - epidemiology ; Male ; Mechanical ventilation ; Morbidity ; Patients ; portosystemic shunt ; prolonged ventilation ; Retrospective Studies ; Survival ; Survival Analysis ; Transplants & implants ; Ventilation ; Ventilators</subject><ispartof>Pediatric transplantation, 2021-11, Vol.25 (7), p.e14088-n/a</ispartof><rights>2021 Wiley Periodicals LLC</rights><rights>2021 Wiley Periodicals LLC.</rights><rights>2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3578-f6235fb2682ab93bb80f75145dbe36f798ac2d7f1bddb9b498ba4831d5134d983</citedby><cites>FETCH-LOGICAL-c3578-f6235fb2682ab93bb80f75145dbe36f798ac2d7f1bddb9b498ba4831d5134d983</cites><orcidid>0000-0002-8114-2523 ; 0000-0001-7266-3848 ; 0000-0001-7152-0546</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpetr.14088$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpetr.14088$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34351678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shanmugam, Naresh</creatorcontrib><creatorcontrib>Hakeem, Abdul Rahman</creatorcontrib><creatorcontrib>Valamparampil, Joseph J.</creatorcontrib><creatorcontrib>Aldouri, Ahmed</creatorcontrib><creatorcontrib>Bansal, Mehak</creatorcontrib><creatorcontrib>Reddy, Mettu Srinivas</creatorcontrib><creatorcontrib>Thiruchunapalli, Deepashree</creatorcontrib><creatorcontrib>Vilca‐Melendez, Hector</creatorcontrib><creatorcontrib>Baker, Alastair</creatorcontrib><creatorcontrib>Dhawan, Anil</creatorcontrib><creatorcontrib>Heaton, Nigel</creatorcontrib><creatorcontrib>Rela, Mohamed</creatorcontrib><creatorcontrib>Deep, Akash</creatorcontrib><title>Improved survival in children with HPS: Experience from two high volume liver transplant centers across continents</title><title>Pediatric transplantation</title><addtitle>Pediatr Transplant</addtitle><description>Background
Severe HPS increases morbidity and mortality after LT in children. We reviewed the combined experience of LT for HPS in children from two LT centers in Europe and Asia.
Methods
All children with “proven” HPS as per ERS Task Force criteria (detailed in manuscript) who underwent LT were categorized into M (PaO2 ≥80 mmHg), Mo (PaO2 = 60–79 mmHg), S (50–59 mmHg), and VS (PaO2 <50 mmHg) HPS, based on room air PaO2.
Results
Twenty‐four children with HPS underwent 25 LT (one re‐transplantation) at a median age of 8 years (IQR, 5–12), after a median duration of 8 (4–12) months following HPS diagnosis. Mechanical ventilation was required for a median of 3 (1.5–27) days after LT. Ten children had “S” post‐operative hypoxemia, requiring iNO for a median of 5 (6–27) days. “VS” category patients had significantly prolonged invasive ventilation (median 35 vs. 3 and 1.5 days; p = .008), ICU stay (median 39 vs. 8 and 8 days; p = .007), and hospital stay (64 vs. 26.5 and 23 days; p < .001) when compared to “S” and “M/Mo” groups, respectively. The need for pre‐transplant home oxygen therapy was the only factor predicting need for re‐intubation. Patient and graft survival at 32 (17–98) months were 100% and 95.8%. All children ultimately had complete resolution of HPS.
Conclusions
VS HPS is associated with longer duration of mechanical ventilation and hospital stay, which emphasizes the need for early LT in these children.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>failed extubation</subject><subject>Female</subject><subject>Graft Survival</subject><subject>Hepatopulmonary Syndrome - mortality</subject><subject>Hepatopulmonary Syndrome - surgery</subject><subject>HPS</subject><subject>Humans</subject><subject>Hypoxemia</subject><subject>Infant</subject><subject>intrapulmonary vascular dilatation</subject><subject>Intubation</subject><subject>Liver Transplantation</subject><subject>Liver transplants</subject><subject>London - epidemiology</subject><subject>Male</subject><subject>Mechanical ventilation</subject><subject>Morbidity</subject><subject>Patients</subject><subject>portosystemic shunt</subject><subject>prolonged ventilation</subject><subject>Retrospective Studies</subject><subject>Survival</subject><subject>Survival Analysis</subject><subject>Transplants & implants</subject><subject>Ventilation</subject><subject>Ventilators</subject><issn>1397-3142</issn><issn>1399-3046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9r3DAQxUVJaf60l36AIOilFJxIlmRLvYWwTQKBLun2bCRr3FWwZUeyvc23j3Y3ySGHzGWG4cdj3jyEvlJyRlOdDzCGM8qJlB_QEWVKZYzw4mA3lxmjPD9ExzHeE0ILLvkndMg4E7Qo5REKN90Q-hksjlOY3axb7Dyu1661ATzeuHGNr5d_fuLF_wGCA18DbkLf4XHT47X7t8Zz304d4NbNEPAYtI9Dq_2Ia_AjhIh1HfoYcd370fm0i5_Rx0a3Eb489xP099didXmd3f6-urm8uM1qJkqZNUXORGPyQubaKGaMJE0pKBfWACuaUkld57ZsqLHWKMOVNJpLRq2gjFsl2Qn6vtdNBh8miGPVuVhDm66DfopVLoTkIid8i357g973U_DpukRJUijKuUrUjz21cxSgqYbgOh0eK0qqbRLVNolql0SCT58lJ9OBfUVfXp8Augc2roXHd6Sq5WJ1txd9AlnqlQw</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Shanmugam, Naresh</creator><creator>Hakeem, Abdul Rahman</creator><creator>Valamparampil, Joseph J.</creator><creator>Aldouri, Ahmed</creator><creator>Bansal, Mehak</creator><creator>Reddy, Mettu Srinivas</creator><creator>Thiruchunapalli, Deepashree</creator><creator>Vilca‐Melendez, Hector</creator><creator>Baker, Alastair</creator><creator>Dhawan, Anil</creator><creator>Heaton, Nigel</creator><creator>Rela, Mohamed</creator><creator>Deep, Akash</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8114-2523</orcidid><orcidid>https://orcid.org/0000-0001-7266-3848</orcidid><orcidid>https://orcid.org/0000-0001-7152-0546</orcidid></search><sort><creationdate>202111</creationdate><title>Improved survival in children with HPS: Experience from two high volume liver transplant centers across continents</title><author>Shanmugam, Naresh ; Hakeem, Abdul Rahman ; Valamparampil, Joseph J. ; Aldouri, Ahmed ; Bansal, Mehak ; Reddy, Mettu Srinivas ; Thiruchunapalli, Deepashree ; Vilca‐Melendez, Hector ; Baker, Alastair ; Dhawan, Anil ; Heaton, Nigel ; Rela, Mohamed ; Deep, Akash</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3578-f6235fb2682ab93bb80f75145dbe36f798ac2d7f1bddb9b498ba4831d5134d983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>failed extubation</topic><topic>Female</topic><topic>Graft Survival</topic><topic>Hepatopulmonary Syndrome - mortality</topic><topic>Hepatopulmonary Syndrome - surgery</topic><topic>HPS</topic><topic>Humans</topic><topic>Hypoxemia</topic><topic>Infant</topic><topic>intrapulmonary vascular dilatation</topic><topic>Intubation</topic><topic>Liver Transplantation</topic><topic>Liver transplants</topic><topic>London - epidemiology</topic><topic>Male</topic><topic>Mechanical ventilation</topic><topic>Morbidity</topic><topic>Patients</topic><topic>portosystemic shunt</topic><topic>prolonged ventilation</topic><topic>Retrospective Studies</topic><topic>Survival</topic><topic>Survival Analysis</topic><topic>Transplants & implants</topic><topic>Ventilation</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shanmugam, Naresh</creatorcontrib><creatorcontrib>Hakeem, Abdul Rahman</creatorcontrib><creatorcontrib>Valamparampil, Joseph J.</creatorcontrib><creatorcontrib>Aldouri, Ahmed</creatorcontrib><creatorcontrib>Bansal, Mehak</creatorcontrib><creatorcontrib>Reddy, Mettu Srinivas</creatorcontrib><creatorcontrib>Thiruchunapalli, Deepashree</creatorcontrib><creatorcontrib>Vilca‐Melendez, Hector</creatorcontrib><creatorcontrib>Baker, Alastair</creatorcontrib><creatorcontrib>Dhawan, Anil</creatorcontrib><creatorcontrib>Heaton, Nigel</creatorcontrib><creatorcontrib>Rela, Mohamed</creatorcontrib><creatorcontrib>Deep, Akash</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shanmugam, Naresh</au><au>Hakeem, Abdul Rahman</au><au>Valamparampil, Joseph J.</au><au>Aldouri, Ahmed</au><au>Bansal, Mehak</au><au>Reddy, Mettu Srinivas</au><au>Thiruchunapalli, Deepashree</au><au>Vilca‐Melendez, Hector</au><au>Baker, Alastair</au><au>Dhawan, Anil</au><au>Heaton, Nigel</au><au>Rela, Mohamed</au><au>Deep, Akash</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved survival in children with HPS: Experience from two high volume liver transplant centers across continents</atitle><jtitle>Pediatric transplantation</jtitle><addtitle>Pediatr Transplant</addtitle><date>2021-11</date><risdate>2021</risdate><volume>25</volume><issue>7</issue><spage>e14088</spage><epage>n/a</epage><pages>e14088-n/a</pages><issn>1397-3142</issn><eissn>1399-3046</eissn><abstract>Background
Severe HPS increases morbidity and mortality after LT in children. We reviewed the combined experience of LT for HPS in children from two LT centers in Europe and Asia.
Methods
All children with “proven” HPS as per ERS Task Force criteria (detailed in manuscript) who underwent LT were categorized into M (PaO2 ≥80 mmHg), Mo (PaO2 = 60–79 mmHg), S (50–59 mmHg), and VS (PaO2 <50 mmHg) HPS, based on room air PaO2.
Results
Twenty‐four children with HPS underwent 25 LT (one re‐transplantation) at a median age of 8 years (IQR, 5–12), after a median duration of 8 (4–12) months following HPS diagnosis. Mechanical ventilation was required for a median of 3 (1.5–27) days after LT. Ten children had “S” post‐operative hypoxemia, requiring iNO for a median of 5 (6–27) days. “VS” category patients had significantly prolonged invasive ventilation (median 35 vs. 3 and 1.5 days; p = .008), ICU stay (median 39 vs. 8 and 8 days; p = .007), and hospital stay (64 vs. 26.5 and 23 days; p < .001) when compared to “S” and “M/Mo” groups, respectively. The need for pre‐transplant home oxygen therapy was the only factor predicting need for re‐intubation. Patient and graft survival at 32 (17–98) months were 100% and 95.8%. All children ultimately had complete resolution of HPS.
Conclusions
VS HPS is associated with longer duration of mechanical ventilation and hospital stay, which emphasizes the need for early LT in these children.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34351678</pmid><doi>10.1111/petr.14088</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8114-2523</orcidid><orcidid>https://orcid.org/0000-0001-7266-3848</orcidid><orcidid>https://orcid.org/0000-0001-7152-0546</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1397-3142 |
| ispartof | Pediatric transplantation, 2021-11, Vol.25 (7), p.e14088-n/a |
| issn | 1397-3142 1399-3046 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2558452048 |
| source | MEDLINE; Wiley Journals |
| subjects | Adolescent Child Child, Preschool Children failed extubation Female Graft Survival Hepatopulmonary Syndrome - mortality Hepatopulmonary Syndrome - surgery HPS Humans Hypoxemia Infant intrapulmonary vascular dilatation Intubation Liver Transplantation Liver transplants London - epidemiology Male Mechanical ventilation Morbidity Patients portosystemic shunt prolonged ventilation Retrospective Studies Survival Survival Analysis Transplants & implants Ventilation Ventilators |
| title | Improved survival in children with HPS: Experience from two high volume liver transplant centers across continents |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T07%3A59%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Improved%20survival%20in%20children%20with%20HPS:%20Experience%20from%20two%20high%20volume%20liver%20transplant%20centers%20across%20continents&rft.jtitle=Pediatric%20transplantation&rft.au=Shanmugam,%20Naresh&rft.date=2021-11&rft.volume=25&rft.issue=7&rft.spage=e14088&rft.epage=n/a&rft.pages=e14088-n/a&rft.issn=1397-3142&rft.eissn=1399-3046&rft_id=info:doi/10.1111/petr.14088&rft_dat=%3Cproquest_cross%3E2580691449%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2580691449&rft_id=info:pmid/34351678&rfr_iscdi=true |