Targeting the Oxytocin System to Ameliorate Early Life Depressive-Like Behaviors in Maternally-Separated Rats

Oxytocin (OXT) —“the love hormone”— has been involved in the anti-depressant activity of some selective serotonin reuptake inhibitors (SSRIs). The exact mechanism underlying the OXT pathway in depression is not fully clear. This study aimed to investigate the effect of OXT analogue, carbetocin (CBT)...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2021/10/01, Vol.44(10), pp.1445-1457
Hauptverfasser:	Abdelwahab, Lobna A., Galal, Omneya O., El-Rahman, Sahar S. Abd, El-Brairy, Amany I., Khattab, Mahmoud M., El-Khatib, Aiman S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic hormone Antidepressants Citalopram early life adversity escitalopram Glial fibrillary acidic protein Hippocampus Inhalation Locomotor activity Maternal behavior maternal separation nebulized carbetocin Open-field behavior Oxytocin Plasma levels Prader-Willi syndrome Serotonin Serotonin transporter Serotonin uptake inhibitors
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