Hypoxia Promotes Breast Cancer Cell Growth by Activating a Glycogen Metabolic Program

Hypoxia is known to be commonly present in breast tumor microenvironments. Stem-like cells that repopulate breast tumors, termed tumor-repopulating cells (TRC), thrive under hypoxic conditions, but the underlying mechanism remains unclear. Here, we show that hypoxia promotes the growth of breast TRC...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2021-10, Vol.81 (19), p.4949-4963
Hauptverfasser:	Tang, Ke, Zhu, Liyan, Chen, Jie, Wang, Dianheng, Zeng, Liping, Chen, Chen, Tang, Liang, Zhou, Li, Wei, Keke, Zhou, Yabo, Lv, Jiadi, Liu, Yuying, Zhang, Huafeng, Ma, Jingwei, Huang, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers Breast Neoplasms - diagnostic imaging Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Cell Proliferation Disease Models, Animal Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Gluconeogenesis Glycogen - metabolism Humans Hypoxia - metabolism Immunohistochemistry Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Metabolic Networks and Pathways Mice NADP - biosynthesis Phosphoenolpyruvate Carboxykinase (GTP) - genetics Phosphoenolpyruvate Carboxykinase (GTP) - metabolism Reactive Oxygen Species - metabolism
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