Rodent models of ketamine‐induced cystitis
Aims Long‐term or recreational use of ketamine affects the urinary system and can result in ketamine‐induced cystitis (KIC). Rodent models of KIC are important to study KIC pathophysiology and are paramount to the future development of therapies for this painful condition. This review aims to provid...
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| Veröffentlicht in: | Neurourology and urodynamics 2021-09, Vol.40 (7), p.1704-1719 |
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| container_issue | 7 |
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| container_title | Neurourology and urodynamics |
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| creator | Sultana, Saki Berger, Geraint Cox, Ashley Kelly, Melanie E. M. Lehmann, Christian |
| description | Aims
Long‐term or recreational use of ketamine affects the urinary system and can result in ketamine‐induced cystitis (KIC). Rodent models of KIC are important to study KIC pathophysiology and are paramount to the future development of therapies for this painful condition. This review aims to provide a summary of rodent models of KIC, focusing on disease induction, experimental methods, and pathological features of the model.
Method
A literature search was performed using the National Center for Biotechnology Information (NCBI) Pubmed database up to March 2021. 20 articles met the inclusion criteria and were finally selected.
Results
There are considerable variations in the rodent models used for studying KIC in terms of the strain of the animal being used; dose, duration, and route of ketamine administration to induce KIC, and assessment of pathological features.
Conclusion
KIC remains difficult to fully recapitulate in humans. Improved characterization of KIC models and the experimental parameters and meticulous discussion on translational limitations are required to improve the translational value of research using rodent models of KIC. |
| doi_str_mv | 10.1002/nau.24763 |
| format | Article |
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Long‐term or recreational use of ketamine affects the urinary system and can result in ketamine‐induced cystitis (KIC). Rodent models of KIC are important to study KIC pathophysiology and are paramount to the future development of therapies for this painful condition. This review aims to provide a summary of rodent models of KIC, focusing on disease induction, experimental methods, and pathological features of the model.
Method
A literature search was performed using the National Center for Biotechnology Information (NCBI) Pubmed database up to March 2021. 20 articles met the inclusion criteria and were finally selected.
Results
There are considerable variations in the rodent models used for studying KIC in terms of the strain of the animal being used; dose, duration, and route of ketamine administration to induce KIC, and assessment of pathological features.
Conclusion
KIC remains difficult to fully recapitulate in humans. Improved characterization of KIC models and the experimental parameters and meticulous discussion on translational limitations are required to improve the translational value of research using rodent models of KIC.</description><identifier>ISSN: 0733-2467</identifier><identifier>EISSN: 1520-6777</identifier><identifier>DOI: 10.1002/nau.24763</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>Animal models ; Biotechnology ; Cystitis ; cystometry ; Ketamine ; rodents ; Translation ; urodynamics</subject><ispartof>Neurourology and urodynamics, 2021-09, Vol.40 (7), p.1704-1719</ispartof><rights>2021 Wiley Periodicals LLC</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3963-7c1943ce6a797cfd85b1336d594917dd513c0703e2ed9dbf6fd50e25daba51c93</citedby><cites>FETCH-LOGICAL-c3963-7c1943ce6a797cfd85b1336d594917dd513c0703e2ed9dbf6fd50e25daba51c93</cites><orcidid>0000-0003-1929-0805</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fnau.24763$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fnau.24763$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids></links><search><creatorcontrib>Sultana, Saki</creatorcontrib><creatorcontrib>Berger, Geraint</creatorcontrib><creatorcontrib>Cox, Ashley</creatorcontrib><creatorcontrib>Kelly, Melanie E. M.</creatorcontrib><creatorcontrib>Lehmann, Christian</creatorcontrib><title>Rodent models of ketamine‐induced cystitis</title><title>Neurourology and urodynamics</title><description>Aims
Long‐term or recreational use of ketamine affects the urinary system and can result in ketamine‐induced cystitis (KIC). Rodent models of KIC are important to study KIC pathophysiology and are paramount to the future development of therapies for this painful condition. This review aims to provide a summary of rodent models of KIC, focusing on disease induction, experimental methods, and pathological features of the model.
Method
A literature search was performed using the National Center for Biotechnology Information (NCBI) Pubmed database up to March 2021. 20 articles met the inclusion criteria and were finally selected.
Results
There are considerable variations in the rodent models used for studying KIC in terms of the strain of the animal being used; dose, duration, and route of ketamine administration to induce KIC, and assessment of pathological features.
Conclusion
KIC remains difficult to fully recapitulate in humans. Improved characterization of KIC models and the experimental parameters and meticulous discussion on translational limitations are required to improve the translational value of research using rodent models of KIC.</description><subject>Animal models</subject><subject>Biotechnology</subject><subject>Cystitis</subject><subject>cystometry</subject><subject>Ketamine</subject><subject>rodents</subject><subject>Translation</subject><subject>urodynamics</subject><issn>0733-2467</issn><issn>1520-6777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp10MtKw0AUBuBBFKzVhW8QcKNg2rlPZlmKNygKYtfDdOYEpuZSMwmSnY_gM_okpsaV4OrffOfn8CN0TvCMYEznle1mlCvJDtCECIpTqZQ6RBOsGEspl-oYncS4xRhnjOsJun6uPVRtUg5RxKTOk1dobRkq-Pr4DJXvHPjE9bENbYin6Ci3RYSz35yi9e3Ny_I-XT3dPSwXq9QxLVmqHNGcOZBWaeVyn4kNYUx6obkmyntBmMMKM6Dgtd_kMvcCAxXebqwgTrMpuhx7d0391kFsTRmig6KwFdRdNFSIjHOdZdlAL_7Qbd011fDdoKTEkmVir65G5Zo6xgZys2tCaZveEGz2u5lhN_Oz22Dno30PBfT_Q_O4WI8X31E1bng</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Sultana, Saki</creator><creator>Berger, Geraint</creator><creator>Cox, Ashley</creator><creator>Kelly, Melanie E. M.</creator><creator>Lehmann, Christian</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1929-0805</orcidid></search><sort><creationdate>202109</creationdate><title>Rodent models of ketamine‐induced cystitis</title><author>Sultana, Saki ; Berger, Geraint ; Cox, Ashley ; Kelly, Melanie E. M. ; Lehmann, Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3963-7c1943ce6a797cfd85b1336d594917dd513c0703e2ed9dbf6fd50e25daba51c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animal models</topic><topic>Biotechnology</topic><topic>Cystitis</topic><topic>cystometry</topic><topic>Ketamine</topic><topic>rodents</topic><topic>Translation</topic><topic>urodynamics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sultana, Saki</creatorcontrib><creatorcontrib>Berger, Geraint</creatorcontrib><creatorcontrib>Cox, Ashley</creatorcontrib><creatorcontrib>Kelly, Melanie E. M.</creatorcontrib><creatorcontrib>Lehmann, Christian</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Neurourology and urodynamics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sultana, Saki</au><au>Berger, Geraint</au><au>Cox, Ashley</au><au>Kelly, Melanie E. M.</au><au>Lehmann, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rodent models of ketamine‐induced cystitis</atitle><jtitle>Neurourology and urodynamics</jtitle><date>2021-09</date><risdate>2021</risdate><volume>40</volume><issue>7</issue><spage>1704</spage><epage>1719</epage><pages>1704-1719</pages><issn>0733-2467</issn><eissn>1520-6777</eissn><abstract>Aims
Long‐term or recreational use of ketamine affects the urinary system and can result in ketamine‐induced cystitis (KIC). Rodent models of KIC are important to study KIC pathophysiology and are paramount to the future development of therapies for this painful condition. This review aims to provide a summary of rodent models of KIC, focusing on disease induction, experimental methods, and pathological features of the model.
Method
A literature search was performed using the National Center for Biotechnology Information (NCBI) Pubmed database up to March 2021. 20 articles met the inclusion criteria and were finally selected.
Results
There are considerable variations in the rodent models used for studying KIC in terms of the strain of the animal being used; dose, duration, and route of ketamine administration to induce KIC, and assessment of pathological features.
Conclusion
KIC remains difficult to fully recapitulate in humans. Improved characterization of KIC models and the experimental parameters and meticulous discussion on translational limitations are required to improve the translational value of research using rodent models of KIC.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/nau.24763</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0003-1929-0805</orcidid></addata></record> |
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| ispartof | Neurourology and urodynamics, 2021-09, Vol.40 (7), p.1704-1719 |
| issn | 0733-2467 1520-6777 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Animal models Biotechnology Cystitis cystometry Ketamine rodents Translation urodynamics |
| title | Rodent models of ketamine‐induced cystitis |
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