Widespread and interrelated gray matter reductions in child sexual offenders with and without pedophilia: Evidence from a multivariate structural MRI study
Aim To further investigate the neuroanatomical correlates of child sexual offending and disentangle them from the neural correlates of pedophilia, using a multivariate analytical approach in order to minimize loss of statistical power. Methods This study presents structural MRI data on gray matter i...
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| Veröffentlicht in: | Psychiatry and clinical neurosciences 2021-11, Vol.75 (11), p.331-340 |
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| creator | Klöckner, Mona S. Jordan, Kirsten Kiehl, Kent A. Nyalakanti, Prashanth K. Harenski, Carla L. Müller, Jürgen L. |
| description | Aim
To further investigate the neuroanatomical correlates of child sexual offending and disentangle them from the neural correlates of pedophilia, using a multivariate analytical approach in order to minimize loss of statistical power.
Methods
This study presents structural MRI data on gray matter in an incarcerated, male population of 22 pedophilic and 21 non‐pedophilic child sexual offenders, and 20 violent non‐sexual offender controls, based on a multivariate whole‐brain approach using source‐based morphometry.
Results
We identify a network of several neuroanatomical regions exhibiting interrelated reduced gray matter in both child sexual offender groups relative to controls, comprising extensive clusters in the bilateral cerebellum and frontal lobe, as well as smaller clusters in the bilateral parietal, temporal, and occipital lobes, the bilateral basal ganglia, the medial cingulate and the hippocampus.
Conclusion
Our results speak to the interpretation that there are inter‐ and possibly connectivity‐related brain structural abnormalities in child sexual offenders that are not (only) pertaining to pedophilia per se. Interpretations and limitations of the present data are discussed and recommendations for future works are given. |
| doi_str_mv | 10.1111/pcn.13292 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2558093474</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2558093474</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4122-549b6a2ab0746d1e4b992103343073c6270580b859712ca123fac7092ea8d12f3</originalsourceid><addsrcrecordid>eNp1kU1PFTEUhhuDAUQW_gHThI0uBvo1M7fszA0iCX7EaFxOOu0ZKZmZjv0A72_xz3LgogsSu-k5zdPntHkJecXZMcd1stj5mEuhxTOyz5ViFV9xvYO1FLLikjd75EVK14wxKRu-S_akkqqpZbtP_vzwDtISwThqZkf9nCFGGE0GR39Gs6GTyXhEI7hisw9zQobaKz86muB3MSMNwwCzg5jorc9XD5r7IpRMF3BhQdabU3p2g6NmC3SIYaKGTmXM_sZEj7NoyhH1JaLu49cLbIvbvCTPBzMmOHzcD8j392ff1h-qy8_nF-t3l5VVXIiqVrpvjDA9a1XjOKhea8Hxq0qyVtpGtKxesX5V65YLa7iQg7Et0wLMynExyAPyZutdYvhVIOVu8snCOJoZQkmdqPG-lqpViB49Qa9DiTO-DinNmFAtl0i93VI2hpQiDN0S_WTipuOsu0-sw8S6h8SQff1oLP0E7h_5NyIETrbArR9h839T92X9aau8A02foRg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2590024713</pqid></control><display><type>article</type><title>Widespread and interrelated gray matter reductions in child sexual offenders with and without pedophilia: Evidence from a multivariate structural MRI study</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Freely Accessible Japanese Titles</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Klöckner, Mona S. ; Jordan, Kirsten ; Kiehl, Kent A. ; Nyalakanti, Prashanth K. ; Harenski, Carla L. ; Müller, Jürgen L.</creator><creatorcontrib>Klöckner, Mona S. ; Jordan, Kirsten ; Kiehl, Kent A. ; Nyalakanti, Prashanth K. ; Harenski, Carla L. ; Müller, Jürgen L.</creatorcontrib><description>Aim
To further investigate the neuroanatomical correlates of child sexual offending and disentangle them from the neural correlates of pedophilia, using a multivariate analytical approach in order to minimize loss of statistical power.
Methods
This study presents structural MRI data on gray matter in an incarcerated, male population of 22 pedophilic and 21 non‐pedophilic child sexual offenders, and 20 violent non‐sexual offender controls, based on a multivariate whole‐brain approach using source‐based morphometry.
Results
We identify a network of several neuroanatomical regions exhibiting interrelated reduced gray matter in both child sexual offender groups relative to controls, comprising extensive clusters in the bilateral cerebellum and frontal lobe, as well as smaller clusters in the bilateral parietal, temporal, and occipital lobes, the bilateral basal ganglia, the medial cingulate and the hippocampus.
Conclusion
Our results speak to the interpretation that there are inter‐ and possibly connectivity‐related brain structural abnormalities in child sexual offenders that are not (only) pertaining to pedophilia per se. Interpretations and limitations of the present data are discussed and recommendations for future works are given.</description><identifier>ISSN: 1323-1316</identifier><identifier>EISSN: 1440-1819</identifier><identifier>DOI: 10.1111/pcn.13292</identifier><identifier>PMID: 34346537</identifier><language>eng</language><publisher>Melbourne: John Wiley & Sons Australia, Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Anatomy ; Basal ganglia ; brain ; Brain architecture ; Cerebellum ; child abuse ; Child sexual abuse ; Criminals - psychology ; Forensic psychiatry ; Frontal lobe ; Gray Matter - diagnostic imaging ; Gray Matter - pathology ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Morphometry ; MRI ; Multivariate Analysis ; Neural networks ; Pedophilia ; Pedophilia - complications ; Pedophilia - pathology ; Sex offenders ; Sex Offenses - psychology ; sexual ; Substantia grisea ; Young Adult</subject><ispartof>Psychiatry and clinical neurosciences, 2021-11, Vol.75 (11), p.331-340</ispartof><rights>2021 The Authors published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology</rights><rights>2021 The Authors Psychiatry and Clinical Neurosciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4122-549b6a2ab0746d1e4b992103343073c6270580b859712ca123fac7092ea8d12f3</citedby><cites>FETCH-LOGICAL-c4122-549b6a2ab0746d1e4b992103343073c6270580b859712ca123fac7092ea8d12f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpcn.13292$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpcn.13292$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34346537$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klöckner, Mona S.</creatorcontrib><creatorcontrib>Jordan, Kirsten</creatorcontrib><creatorcontrib>Kiehl, Kent A.</creatorcontrib><creatorcontrib>Nyalakanti, Prashanth K.</creatorcontrib><creatorcontrib>Harenski, Carla L.</creatorcontrib><creatorcontrib>Müller, Jürgen L.</creatorcontrib><title>Widespread and interrelated gray matter reductions in child sexual offenders with and without pedophilia: Evidence from a multivariate structural MRI study</title><title>Psychiatry and clinical neurosciences</title><addtitle>Psychiatry Clin Neurosci</addtitle><description>Aim
To further investigate the neuroanatomical correlates of child sexual offending and disentangle them from the neural correlates of pedophilia, using a multivariate analytical approach in order to minimize loss of statistical power.
Methods
This study presents structural MRI data on gray matter in an incarcerated, male population of 22 pedophilic and 21 non‐pedophilic child sexual offenders, and 20 violent non‐sexual offender controls, based on a multivariate whole‐brain approach using source‐based morphometry.
Results
We identify a network of several neuroanatomical regions exhibiting interrelated reduced gray matter in both child sexual offender groups relative to controls, comprising extensive clusters in the bilateral cerebellum and frontal lobe, as well as smaller clusters in the bilateral parietal, temporal, and occipital lobes, the bilateral basal ganglia, the medial cingulate and the hippocampus.
Conclusion
Our results speak to the interpretation that there are inter‐ and possibly connectivity‐related brain structural abnormalities in child sexual offenders that are not (only) pertaining to pedophilia per se. Interpretations and limitations of the present data are discussed and recommendations for future works are given.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anatomy</subject><subject>Basal ganglia</subject><subject>brain</subject><subject>Brain architecture</subject><subject>Cerebellum</subject><subject>child abuse</subject><subject>Child sexual abuse</subject><subject>Criminals - psychology</subject><subject>Forensic psychiatry</subject><subject>Frontal lobe</subject><subject>Gray Matter - diagnostic imaging</subject><subject>Gray Matter - pathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Morphometry</subject><subject>MRI</subject><subject>Multivariate Analysis</subject><subject>Neural networks</subject><subject>Pedophilia</subject><subject>Pedophilia - complications</subject><subject>Pedophilia - pathology</subject><subject>Sex offenders</subject><subject>Sex Offenses - psychology</subject><subject>sexual</subject><subject>Substantia grisea</subject><subject>Young Adult</subject><issn>1323-1316</issn><issn>1440-1819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kU1PFTEUhhuDAUQW_gHThI0uBvo1M7fszA0iCX7EaFxOOu0ZKZmZjv0A72_xz3LgogsSu-k5zdPntHkJecXZMcd1stj5mEuhxTOyz5ViFV9xvYO1FLLikjd75EVK14wxKRu-S_akkqqpZbtP_vzwDtISwThqZkf9nCFGGE0GR39Gs6GTyXhEI7hisw9zQobaKz86muB3MSMNwwCzg5jorc9XD5r7IpRMF3BhQdabU3p2g6NmC3SIYaKGTmXM_sZEj7NoyhH1JaLu49cLbIvbvCTPBzMmOHzcD8j392ff1h-qy8_nF-t3l5VVXIiqVrpvjDA9a1XjOKhea8Hxq0qyVtpGtKxesX5V65YLa7iQg7Et0wLMynExyAPyZutdYvhVIOVu8snCOJoZQkmdqPG-lqpViB49Qa9DiTO-DinNmFAtl0i93VI2hpQiDN0S_WTipuOsu0-sw8S6h8SQff1oLP0E7h_5NyIETrbArR9h839T92X9aau8A02foRg</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Klöckner, Mona S.</creator><creator>Jordan, Kirsten</creator><creator>Kiehl, Kent A.</creator><creator>Nyalakanti, Prashanth K.</creator><creator>Harenski, Carla L.</creator><creator>Müller, Jürgen L.</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>202111</creationdate><title>Widespread and interrelated gray matter reductions in child sexual offenders with and without pedophilia: Evidence from a multivariate structural MRI study</title><author>Klöckner, Mona S. ; Jordan, Kirsten ; Kiehl, Kent A. ; Nyalakanti, Prashanth K. ; Harenski, Carla L. ; Müller, Jürgen L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4122-549b6a2ab0746d1e4b992103343073c6270580b859712ca123fac7092ea8d12f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anatomy</topic><topic>Basal ganglia</topic><topic>brain</topic><topic>Brain architecture</topic><topic>Cerebellum</topic><topic>child abuse</topic><topic>Child sexual abuse</topic><topic>Criminals - psychology</topic><topic>Forensic psychiatry</topic><topic>Frontal lobe</topic><topic>Gray Matter - diagnostic imaging</topic><topic>Gray Matter - pathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Morphometry</topic><topic>MRI</topic><topic>Multivariate Analysis</topic><topic>Neural networks</topic><topic>Pedophilia</topic><topic>Pedophilia - complications</topic><topic>Pedophilia - pathology</topic><topic>Sex offenders</topic><topic>Sex Offenses - psychology</topic><topic>sexual</topic><topic>Substantia grisea</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klöckner, Mona S.</creatorcontrib><creatorcontrib>Jordan, Kirsten</creatorcontrib><creatorcontrib>Kiehl, Kent A.</creatorcontrib><creatorcontrib>Nyalakanti, Prashanth K.</creatorcontrib><creatorcontrib>Harenski, Carla L.</creatorcontrib><creatorcontrib>Müller, Jürgen L.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry and clinical neurosciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klöckner, Mona S.</au><au>Jordan, Kirsten</au><au>Kiehl, Kent A.</au><au>Nyalakanti, Prashanth K.</au><au>Harenski, Carla L.</au><au>Müller, Jürgen L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Widespread and interrelated gray matter reductions in child sexual offenders with and without pedophilia: Evidence from a multivariate structural MRI study</atitle><jtitle>Psychiatry and clinical neurosciences</jtitle><addtitle>Psychiatry Clin Neurosci</addtitle><date>2021-11</date><risdate>2021</risdate><volume>75</volume><issue>11</issue><spage>331</spage><epage>340</epage><pages>331-340</pages><issn>1323-1316</issn><eissn>1440-1819</eissn><abstract>Aim
To further investigate the neuroanatomical correlates of child sexual offending and disentangle them from the neural correlates of pedophilia, using a multivariate analytical approach in order to minimize loss of statistical power.
Methods
This study presents structural MRI data on gray matter in an incarcerated, male population of 22 pedophilic and 21 non‐pedophilic child sexual offenders, and 20 violent non‐sexual offender controls, based on a multivariate whole‐brain approach using source‐based morphometry.
Results
We identify a network of several neuroanatomical regions exhibiting interrelated reduced gray matter in both child sexual offender groups relative to controls, comprising extensive clusters in the bilateral cerebellum and frontal lobe, as well as smaller clusters in the bilateral parietal, temporal, and occipital lobes, the bilateral basal ganglia, the medial cingulate and the hippocampus.
Conclusion
Our results speak to the interpretation that there are inter‐ and possibly connectivity‐related brain structural abnormalities in child sexual offenders that are not (only) pertaining to pedophilia per se. Interpretations and limitations of the present data are discussed and recommendations for future works are given.</abstract><cop>Melbourne</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>34346537</pmid><doi>10.1111/pcn.13292</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Free Content; MEDLINE; Freely Accessible Japanese Titles; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Anatomy Basal ganglia brain Brain architecture Cerebellum child abuse Child sexual abuse Criminals - psychology Forensic psychiatry Frontal lobe Gray Matter - diagnostic imaging Gray Matter - pathology Humans Magnetic Resonance Imaging Male Middle Aged Morphometry MRI Multivariate Analysis Neural networks Pedophilia Pedophilia - complications Pedophilia - pathology Sex offenders Sex Offenses - psychology sexual Substantia grisea Young Adult |
| title | Widespread and interrelated gray matter reductions in child sexual offenders with and without pedophilia: Evidence from a multivariate structural MRI study |
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