Optogenetic manipulation of the prelimbic cortex during fear memory reconsolidation alters fear extinction in a preclinical model of comorbid PTSD/AUD

Rationale and objective Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are disorders of learning and memory that often occur comorbidly. Exposure to trauma-related cues can increase alcohol intake in PTSD patients that are using alcohol to self-medicate. The recurrence of anxie...

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Veröffentlicht in:	Psychopharmacology 2021-11, Vol.238 (11), p.3193-3206
Hauptverfasser:	Smiley, C. E., McGonigal, J. T., Nimchuk, K. E., Gass, J. T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abuse Alcohol Alcohol abuse Alcohol use Alcohol, Denatured Alcoholism Analysis Animals Biomedical and Life Sciences Biomedicine Comorbidity Dosage and administration Drug abuse Drug self-administration Ethanol Extinction behavior Extinction, Psychological Fear Fear conditioning Genetics Humans Information processing Learning Methods Neural circuitry Neurosciences Optics Optogenetics Original Investigation Pharmacology/Toxicology Physiological aspects Post traumatic stress disorder Prefrontal Cortex Psychiatry Rats Spontaneous recovery Stress Disorders, Post-Traumatic Tonic immobility Trauma
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