Lipopolysaccharide-induced maternal immune activation modulates microglial CX3CR1 protein expression and morphological phenotype in the hippocampus and dentate gyrus, resulting in cognitive inflexibility during late adolescence

•MIA reduces microglial CX3CR1 protein but not cell density in LPS-male offspring.•Predominant ameboid microglia in LPS-male offspring suggest microglial priming.•Anti-inflammatory IL-10, detectable in fetal brain, results in short-lived upregulation.•Cognitive inflexibility is significantly observe...

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Veröffentlicht in:Brain, behavior, and immunity behavior, and immunity, 2021-10, Vol.97, p.440-454
Hauptverfasser: Fernández de Cossío, Lourdes, Lacabanne, Chloé, Bordeleau, Maude, Castino, Garance, Kyriakakis, Phillip, Tremblay, Marie-Ève
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Sprache:eng
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