The light chain of antibodies specific to the V2 region of HIV-1 can determine their function

We studied the contribution of the light chain to functions of human monoclonal antibodies (mAbs) by measuring the relationships between the rate of mutations and cross-reactivity, binding affinity and neutralization activity. We analyzed 12 mAbs of two clonal families specific to the V2 region of H...

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Veröffentlicht in:	Human immunology 2021-12, Vol.82 (12), p.923-929
Hauptverfasser:	Li, Liuzhe, Wang, Xiao-Hong, Nanfack, Aubin, Kong, Xiang-Peng, Gorny, Miroslaw K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Monoclonal - genetics Antibodies, Monoclonal - immunology Clonal antibodies Female HIV antibodies HIV Antibodies - genetics HIV Antibodies - immunology HIV Infections - genetics HIV Infections - immunology HIV-1 - genetics HIV-1 - immunology Humans Immunoglobulin Light Chains - genetics Immunoglobulin Light Chains - immunology Immunoglobulin Variable Region - genetics Immunoglobulin Variable Region - immunology Light chain of antibody Male Somatic hypermutations
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