Adenosine A2B receptor down‐regulates metabotropic glutamate receptor 5 in astrocytes during postnatal development

Metabotropic glutamate receptor 5 (mGluR5) in astrocytes is a key molecule for controlling synapse remodeling. Although mGluR5 is abundant in neonatal astrocytes, its level is gradually down‐regulated during development and is almost absent in the adult. However, in several pathological conditions,...

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Veröffentlicht in:	Glia 2021-11, Vol.69 (11), p.2546-2558
Hauptverfasser:	Tanaka, Masayoshi, Shigetomi, Eiji, Parajuli, Bijay, Nagatomo, Hiroaki, Shinozaki, Youichi, Hirayama, Yuri, Saito, Kozo, Kubota, Yuto, Danjo, Yosuke, Lee, Ji Hwan, Kim, Sun Kwang, Nabekura, Junichi, Koizumi, Schuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine adenosine A2B receptor Adenosine triphosphate Astrocytes ATP Calcium imaging Calcium ions development Gene expression Glutamate receptors Glutamic acid receptors (metabotropic) Medical imaging Metabolites mGluR5 Neonates Pathogenesis Receptors Synapses Synaptogenesis
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