Sepsis hysteria? Not for children – Authors' reply

Thankfully, paediatric sepsis trials in high-income countries have not used mortality as the primary endpoint for many years, citing “affordability”.2 A point-prevalence study of 6925 children across 128 paediatric intensive care units in 26 countries identified 569 children who fulfilled sepsis cri...

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Veröffentlicht in:The Lancet (British edition) 2020-10, Vol.396 (10259), p.1333-1334
Hauptverfasser: Singer, Mervyn, Inada-Kim, Matt, Peters, Mark, Maitland, Kathryn
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container_issue 10259
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container_title The Lancet (British edition)
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creator Singer, Mervyn
Inada-Kim, Matt
Peters, Mark
Maitland, Kathryn
description Thankfully, paediatric sepsis trials in high-income countries have not used mortality as the primary endpoint for many years, citing “affordability”.2 A point-prevalence study of 6925 children across 128 paediatric intensive care units in 26 countries identified 569 children who fulfilled sepsis criteria.3 Of these patients, 439 children (77%) had one or more comorbid conditions that could independently limit survival, including solid organ or stem-cell transplants, malignancy, renal disease, and haematological or immunological conditions. The authors estimated that an intervention trial would take 3 years for 2118 patients to be enrolled from 58 paediatric intensive care units for 80% power to detect a 5% absolute risk reduction in mortality. With respect to low-income and middle-income countries, paediatric mortality rates are indeed higher than in high-income countries; however, what is the true incidence, and in what proportion could antibacterial therapy be potentially life-saving?
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subjects Antibiotics
Antiinfectives and antibacterials
Child
Children
Clinical trials
Fatalities
Hospitals
Humans
Hysteria
Immunology
Income
Intensive care
Intensive care units
Kidney transplantation
Malignancy
Mortality
Pathogens
Pediatrics
Pneumonia
Risk management
Sepsis
Sepsis - diagnosis
Streptococcus infections
Transplants
title Sepsis hysteria? Not for children – Authors' reply
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