Effect of the BCAT2 polymorphism (rs11548193) on plasma branched-chain amino acid concentrations after dietary intervention in subjects with obesity and insulin resistance
Branched-chain amino acids (BCAA) are considered markers of insulin resistance (IR) in subjects with obesity. In this study, we evaluated whether the presence of the SNP of the branched-chain aminotransferase 2 (BCAT2) gene can modify the effect of a dietary intervention (DI) on the plasma concentra...
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| Veröffentlicht in: | British journal of nutrition 2022-07, Vol.128 (1), p.43-54 |
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| creator | González-Salazar, Luis E. Granados-Portillo, Omar Medina-Vera, Isabel Pichardo-Ontiveros, Edgar Vigil-Martínez, Ana Guizar-Heredia, Rocío Palacios-González, Berenice Arteaga-Sánchez, Liliana Hernández-Gómez, Karla G. Avila-Nava, Azalia Serralde-Zúñiga, Aurora E. Flores-López, Adriana Noriega, Lilia G. Torres, Nimbe Olin-Sandoval, Viridiana Vázquez-Manjarrez, Natalia Domínguez-Velázquez, Natali Reyes-García, Juan G. Tovar, Armando R. Guevara-Cruz, Martha |
| description | Branched-chain amino acids (BCAA) are considered markers of insulin resistance (IR) in subjects with obesity. In this study, we evaluated whether the presence of the SNP of the branched-chain aminotransferase 2 (BCAT2) gene can modify the effect of a dietary intervention (DI) on the plasma concentration of BCAA in subjects with obesity and IR. A prospective cohort study of adult subjects with obesity, BMI ≥ 30 kg/m2, homeostatic model assessment-insulin resistance (HOMA-IR ≥ 2·5) no diagnosed chronic disease, underwent a DI with an energy restriction of 3140 kJ/d and nutritional education for 1 month. Anthropometric measurements, body composition, blood pressure, resting energy expenditure, oral glucose tolerance test results, serum biochemical parameters and the plasma amino acid profile were evaluated before and after the DI. SNP were assessed by the TaqMan SNP genotyping assay. A total of eighty-two subjects were included, and fifteen subjects with a BCAT2 SNP had a greater reduction in leucine, isoleucine, valine and the sum of BCAA. Those subjects also had a greater reduction in skeletal muscle mass, fat-free mass, total body water, blood pressure, muscle strength and biochemical parameters after 1 month of the DI and adjusting for age and sex. This study demonstrated that the presence of the BCAT2 SNP promotes a greater reduction in plasma BCAA concentration after adjusting for age and sex, in subjects with obesity and IR after a 1-month energy-restricted DI. |
| doi_str_mv | 10.1017/S0007114521002920 |
| format | Article |
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In this study, we evaluated whether the presence of the SNP of the branched-chain aminotransferase 2 (BCAT2) gene can modify the effect of a dietary intervention (DI) on the plasma concentration of BCAA in subjects with obesity and IR. A prospective cohort study of adult subjects with obesity, BMI ≥ 30 kg/m2, homeostatic model assessment-insulin resistance (HOMA-IR ≥ 2·5) no diagnosed chronic disease, underwent a DI with an energy restriction of 3140 kJ/d and nutritional education for 1 month. Anthropometric measurements, body composition, blood pressure, resting energy expenditure, oral glucose tolerance test results, serum biochemical parameters and the plasma amino acid profile were evaluated before and after the DI. SNP were assessed by the TaqMan SNP genotyping assay. A total of eighty-two subjects were included, and fifteen subjects with a BCAT2 SNP had a greater reduction in leucine, isoleucine, valine and the sum of BCAA. Those subjects also had a greater reduction in skeletal muscle mass, fat-free mass, total body water, blood pressure, muscle strength and biochemical parameters after 1 month of the DI and adjusting for age and sex. This study demonstrated that the presence of the BCAT2 SNP promotes a greater reduction in plasma BCAA concentration after adjusting for age and sex, in subjects with obesity and IR after a 1-month energy-restricted DI.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114521002920</identifier><identifier>PMID: 34340727</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Acid resistance ; Adult ; Amino acids ; Amino Acids, Branched-Chain ; Blood Glucose - metabolism ; Blood pressure ; Body composition ; Body water ; Chain branching ; Chains ; Cholesterol ; Chronic illnesses ; Diabetes ; Diet ; Energy ; Energy expenditure ; Evaluation ; Fat-free body mass ; Food ; Genotyping ; Glucose ; Glucose tolerance ; Human and Clinical Nutrition ; Humans ; Insulin ; Insulin Resistance ; Isoleucine ; Leucine ; Minor Histocompatibility Antigens ; Muscle strength ; Musculoskeletal system ; Nutrition research ; Obesity ; Obesity - metabolism ; Parameters ; Phosphorylation ; Plasma ; Polymorphism ; Pregnancy Proteins - genetics ; Prospective Studies ; Proteins ; Reduction ; Sex ; Single-nucleotide polymorphism ; Skeletal muscle ; Transaminases - genetics ; Valine ; Weight control</subject><ispartof>British journal of nutrition, 2022-07, Vol.128 (1), p.43-54</ispartof><rights>The Author(s), 2021. Published by Cambridge University Press on behalf of The Nutrition Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c325t-d0d10cca2c9b939f1a87b40a1cf48917e20fb709b61bb7754ad3d6b51846ca593</cites><orcidid>0000-0002-8996-3481 ; 0000-0003-2752-1204</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114521002920/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34340727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>González-Salazar, Luis E.</creatorcontrib><creatorcontrib>Granados-Portillo, Omar</creatorcontrib><creatorcontrib>Medina-Vera, Isabel</creatorcontrib><creatorcontrib>Pichardo-Ontiveros, Edgar</creatorcontrib><creatorcontrib>Vigil-Martínez, Ana</creatorcontrib><creatorcontrib>Guizar-Heredia, Rocío</creatorcontrib><creatorcontrib>Palacios-González, Berenice</creatorcontrib><creatorcontrib>Arteaga-Sánchez, Liliana</creatorcontrib><creatorcontrib>Hernández-Gómez, Karla G.</creatorcontrib><creatorcontrib>Avila-Nava, Azalia</creatorcontrib><creatorcontrib>Serralde-Zúñiga, Aurora E.</creatorcontrib><creatorcontrib>Flores-López, Adriana</creatorcontrib><creatorcontrib>Noriega, Lilia G.</creatorcontrib><creatorcontrib>Torres, Nimbe</creatorcontrib><creatorcontrib>Olin-Sandoval, Viridiana</creatorcontrib><creatorcontrib>Vázquez-Manjarrez, Natalia</creatorcontrib><creatorcontrib>Domínguez-Velázquez, Natali</creatorcontrib><creatorcontrib>Reyes-García, Juan G.</creatorcontrib><creatorcontrib>Tovar, Armando R.</creatorcontrib><creatorcontrib>Guevara-Cruz, Martha</creatorcontrib><title>Effect of the BCAT2 polymorphism (rs11548193) on plasma branched-chain amino acid concentrations after dietary intervention in subjects with obesity and insulin resistance</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Branched-chain amino acids (BCAA) are considered markers of insulin resistance (IR) in subjects with obesity. In this study, we evaluated whether the presence of the SNP of the branched-chain aminotransferase 2 (BCAT2) gene can modify the effect of a dietary intervention (DI) on the plasma concentration of BCAA in subjects with obesity and IR. A prospective cohort study of adult subjects with obesity, BMI ≥ 30 kg/m2, homeostatic model assessment-insulin resistance (HOMA-IR ≥ 2·5) no diagnosed chronic disease, underwent a DI with an energy restriction of 3140 kJ/d and nutritional education for 1 month. Anthropometric measurements, body composition, blood pressure, resting energy expenditure, oral glucose tolerance test results, serum biochemical parameters and the plasma amino acid profile were evaluated before and after the DI. SNP were assessed by the TaqMan SNP genotyping assay. A total of eighty-two subjects were included, and fifteen subjects with a BCAT2 SNP had a greater reduction in leucine, isoleucine, valine and the sum of BCAA. Those subjects also had a greater reduction in skeletal muscle mass, fat-free mass, total body water, blood pressure, muscle strength and biochemical parameters after 1 month of the DI and adjusting for age and sex. This study demonstrated that the presence of the BCAT2 SNP promotes a greater reduction in plasma BCAA concentration after adjusting for age and sex, in subjects with obesity and IR after a 1-month energy-restricted DI.</description><subject>Acid resistance</subject><subject>Adult</subject><subject>Amino acids</subject><subject>Amino Acids, Branched-Chain</subject><subject>Blood Glucose - metabolism</subject><subject>Blood pressure</subject><subject>Body composition</subject><subject>Body water</subject><subject>Chain branching</subject><subject>Chains</subject><subject>Cholesterol</subject><subject>Chronic illnesses</subject><subject>Diabetes</subject><subject>Diet</subject><subject>Energy</subject><subject>Energy expenditure</subject><subject>Evaluation</subject><subject>Fat-free body mass</subject><subject>Food</subject><subject>Genotyping</subject><subject>Glucose</subject><subject>Glucose tolerance</subject><subject>Human and Clinical Nutrition</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Isoleucine</subject><subject>Leucine</subject><subject>Minor Histocompatibility Antigens</subject><subject>Muscle strength</subject><subject>Musculoskeletal system</subject><subject>Nutrition research</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Parameters</subject><subject>Phosphorylation</subject><subject>Plasma</subject><subject>Polymorphism</subject><subject>Pregnancy Proteins - genetics</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Reduction</subject><subject>Sex</subject><subject>Single-nucleotide polymorphism</subject><subject>Skeletal muscle</subject><subject>Transaminases - genetics</subject><subject>Valine</subject><subject>Weight control</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1Uctu1DAUtRCITgsfwAZZYtMuAr6OHcfLMioPqRILyjryK8SjxB5sp2i-iZ_Eow4ggVhZx-dl-SD0AshrICDefCaECADGKRBCJSWP0AaY4A3tOvoYbY50c-TP0HnOuwp7IPIpOmtZy4igYoN-3IyjMwXHEZfJ4bfb6zuK93E-LDHtJ58XfJkyAGc9yPYKx4D3s8qLwjqpYCZnGzMpH7BafIhYGW-xicG4UJIqPoaM1Vhcwta7otIB-1DRfaUrVwHOq97V_oy_-zLhqF325YBVsJXM61wVqV7lUsvcM_RkVHN2z0_nBfry7uZu-6G5_fT-4_b6tjEt5aWxxAIxRlEjtWzlCKoXmhEFZmS9BOEoGbUgUnegtRCcKdvaTnPoWWcUl-0FunzI3af4bXW5DIvPxs2zCi6ueaCcVxfjBKr01V_SXVxTqK8baNf3RDBJaFXBg8qkmHNy47BPfqnfMQAZjksO_yxZPS9PyatenP3t-DVdFbSnULXo5O1X96f7_7E_AUYnqNk</recordid><startdate>20220714</startdate><enddate>20220714</enddate><creator>González-Salazar, Luis E.</creator><creator>Granados-Portillo, Omar</creator><creator>Medina-Vera, Isabel</creator><creator>Pichardo-Ontiveros, Edgar</creator><creator>Vigil-Martínez, Ana</creator><creator>Guizar-Heredia, Rocío</creator><creator>Palacios-González, Berenice</creator><creator>Arteaga-Sánchez, Liliana</creator><creator>Hernández-Gómez, Karla G.</creator><creator>Avila-Nava, Azalia</creator><creator>Serralde-Zúñiga, Aurora E.</creator><creator>Flores-López, Adriana</creator><creator>Noriega, Lilia G.</creator><creator>Torres, Nimbe</creator><creator>Olin-Sandoval, Viridiana</creator><creator>Vázquez-Manjarrez, Natalia</creator><creator>Domínguez-Velázquez, Natali</creator><creator>Reyes-García, Juan G.</creator><creator>Tovar, Armando R.</creator><creator>Guevara-Cruz, Martha</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8996-3481</orcidid><orcidid>https://orcid.org/0000-0003-2752-1204</orcidid></search><sort><creationdate>20220714</creationdate><title>Effect of the BCAT2 polymorphism (rs11548193) on plasma branched-chain amino acid concentrations after dietary intervention in subjects with obesity and insulin resistance</title><author>González-Salazar, Luis E. ; Granados-Portillo, Omar ; Medina-Vera, Isabel ; Pichardo-Ontiveros, Edgar ; Vigil-Martínez, Ana ; Guizar-Heredia, Rocío ; Palacios-González, Berenice ; Arteaga-Sánchez, Liliana ; Hernández-Gómez, Karla G. ; Avila-Nava, Azalia ; Serralde-Zúñiga, Aurora E. ; Flores-López, Adriana ; Noriega, Lilia G. ; Torres, Nimbe ; Olin-Sandoval, Viridiana ; Vázquez-Manjarrez, Natalia ; Domínguez-Velázquez, Natali ; Reyes-García, Juan G. ; Tovar, Armando R. ; Guevara-Cruz, Martha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c325t-d0d10cca2c9b939f1a87b40a1cf48917e20fb709b61bb7754ad3d6b51846ca593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acid resistance</topic><topic>Adult</topic><topic>Amino acids</topic><topic>Amino Acids, Branched-Chain</topic><topic>Blood Glucose - metabolism</topic><topic>Blood pressure</topic><topic>Body composition</topic><topic>Body water</topic><topic>Chain branching</topic><topic>Chains</topic><topic>Cholesterol</topic><topic>Chronic illnesses</topic><topic>Diabetes</topic><topic>Diet</topic><topic>Energy</topic><topic>Energy expenditure</topic><topic>Evaluation</topic><topic>Fat-free body mass</topic><topic>Food</topic><topic>Genotyping</topic><topic>Glucose</topic><topic>Glucose tolerance</topic><topic>Human and Clinical Nutrition</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin Resistance</topic><topic>Isoleucine</topic><topic>Leucine</topic><topic>Minor Histocompatibility Antigens</topic><topic>Muscle strength</topic><topic>Musculoskeletal system</topic><topic>Nutrition research</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>Parameters</topic><topic>Phosphorylation</topic><topic>Plasma</topic><topic>Polymorphism</topic><topic>Pregnancy Proteins - genetics</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>Reduction</topic><topic>Sex</topic><topic>Single-nucleotide polymorphism</topic><topic>Skeletal muscle</topic><topic>Transaminases - 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In this study, we evaluated whether the presence of the SNP of the branched-chain aminotransferase 2 (BCAT2) gene can modify the effect of a dietary intervention (DI) on the plasma concentration of BCAA in subjects with obesity and IR. A prospective cohort study of adult subjects with obesity, BMI ≥ 30 kg/m2, homeostatic model assessment-insulin resistance (HOMA-IR ≥ 2·5) no diagnosed chronic disease, underwent a DI with an energy restriction of 3140 kJ/d and nutritional education for 1 month. Anthropometric measurements, body composition, blood pressure, resting energy expenditure, oral glucose tolerance test results, serum biochemical parameters and the plasma amino acid profile were evaluated before and after the DI. SNP were assessed by the TaqMan SNP genotyping assay. A total of eighty-two subjects were included, and fifteen subjects with a BCAT2 SNP had a greater reduction in leucine, isoleucine, valine and the sum of BCAA. Those subjects also had a greater reduction in skeletal muscle mass, fat-free mass, total body water, blood pressure, muscle strength and biochemical parameters after 1 month of the DI and adjusting for age and sex. This study demonstrated that the presence of the BCAT2 SNP promotes a greater reduction in plasma BCAA concentration after adjusting for age and sex, in subjects with obesity and IR after a 1-month energy-restricted DI.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>34340727</pmid><doi>10.1017/S0007114521002920</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-8996-3481</orcidid><orcidid>https://orcid.org/0000-0003-2752-1204</orcidid></addata></record> |
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| ispartof | British journal of nutrition, 2022-07, Vol.128 (1), p.43-54 |
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| recordid | cdi_proquest_miscellaneous_2557544501 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Cambridge Journals; Free Full-Text Journals in Chemistry |
| subjects | Acid resistance Adult Amino acids Amino Acids, Branched-Chain Blood Glucose - metabolism Blood pressure Body composition Body water Chain branching Chains Cholesterol Chronic illnesses Diabetes Diet Energy Energy expenditure Evaluation Fat-free body mass Food Genotyping Glucose Glucose tolerance Human and Clinical Nutrition Humans Insulin Insulin Resistance Isoleucine Leucine Minor Histocompatibility Antigens Muscle strength Musculoskeletal system Nutrition research Obesity Obesity - metabolism Parameters Phosphorylation Plasma Polymorphism Pregnancy Proteins - genetics Prospective Studies Proteins Reduction Sex Single-nucleotide polymorphism Skeletal muscle Transaminases - genetics Valine Weight control |
| title | Effect of the BCAT2 polymorphism (rs11548193) on plasma branched-chain amino acid concentrations after dietary intervention in subjects with obesity and insulin resistance |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T06%3A11%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20the%20BCAT2%20polymorphism%20(rs11548193)%20on%20plasma%20branched-chain%20amino%20acid%20concentrations%20after%20dietary%20intervention%20in%20subjects%20with%20obesity%20and%20insulin%20resistance&rft.jtitle=British%20journal%20of%20nutrition&rft.au=Gonz%C3%A1lez-Salazar,%20Luis%20E.&rft.date=2022-07-14&rft.volume=128&rft.issue=1&rft.spage=43&rft.epage=54&rft.pages=43-54&rft.issn=0007-1145&rft.eissn=1475-2662&rft_id=info:doi/10.1017/S0007114521002920&rft_dat=%3Cproquest_cross%3E2688074902%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2688074902&rft_id=info:pmid/34340727&rft_cupid=10_1017_S0007114521002920&rfr_iscdi=true |