Design, synthesis, and biological evaluation of N-(4-substituted)-3-phenylisoxazolo[5,4–d]pyrimidin-4-amine derivatives as apoptosis-inducing cytotoxic agents

[Display omitted] •All the 28 derivatives synthesized were evaluated on the NCI-60-cell line panel.•Compound 10 h was the most potent derivative with the IC50 – 0.64 ± 0.07 μM on human breast adenocarcinoma (BT-474).•Compound 10h was evaluated for apoptosis induction as a primary mechanism of action...

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