Anterior segment optical coherence tomography angiography in the assessment of ocular surface lesions
Describe the utility of anterior segment optical coherence tomography angiography (AS-OCTA) to assess ocular surface lesions. Retrospective, case-control study of 10 eyes of 9 patients with malignant lesions and 23 eyes of 22 patients with benign lesions. Lesions included 13 epithelial, 10 pigmented...
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| Veröffentlicht in: | The ocular surface 2021-10, Vol.22, p.86-93 |
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| creator | Binotti, William W. Mills, Huan Nosé, Ricardo M. Wu, Helen K. Duker, Jay S. Hamrah, Pedram |
| description | Describe the utility of anterior segment optical coherence tomography angiography (AS-OCTA) to assess ocular surface lesions.
Retrospective, case-control study of 10 eyes of 9 patients with malignant lesions and 23 eyes of 22 patients with benign lesions. Lesions included 13 epithelial, 10 pigmented and 10 lymphoid lesions. Graders performed an average of 3 depth and diameter measurements of peri-lesional vessels entering each lesion on AS-OCTA. Statistical models to assess differences between groups accounted for bilateral eye inclusion and lesion thickness (on AS-OCT). Receiver operating characteristic (ROC) curve and area under the curve (AUC) were performed for each parameter.
In the benign and malignant groups, age was 49.5 ± 22.4 and 64.3 ± 10.6 years (p = 0.145) with 45% males and 55% males (p = 0.458), in their respective groups. AS-OCTA showed greater peri-lesional vessel depth and diameter in malignant lesions (315.2 ± 73.0 μm, p |
| doi_str_mv | 10.1016/j.jtos.2021.07.009 |
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Retrospective, case-control study of 10 eyes of 9 patients with malignant lesions and 23 eyes of 22 patients with benign lesions. Lesions included 13 epithelial, 10 pigmented and 10 lymphoid lesions. Graders performed an average of 3 depth and diameter measurements of peri-lesional vessels entering each lesion on AS-OCTA. Statistical models to assess differences between groups accounted for bilateral eye inclusion and lesion thickness (on AS-OCT). Receiver operating characteristic (ROC) curve and area under the curve (AUC) were performed for each parameter.
In the benign and malignant groups, age was 49.5 ± 22.4 and 64.3 ± 10.6 years (p = 0.145) with 45% males and 55% males (p = 0.458), in their respective groups. AS-OCTA showed greater peri-lesional vessel depth and diameter in malignant lesions (315.2 ± 73.0 μm, p < 0.001 and 76.4 ± 18.2 μm, p < 0.001; respectively) compared to benign lesions (199.4 ± 34.1 μm and 44.0 ± 9.4 μm, respectively). Malignant lesions showed deep and dilated peri-lesional vessels, which may represent feeder vessels. Vessel depth showed AUC = 0.980, 90.9% sensitivity and 100.0% specificity with a 236.5 μm cutoff. Vessel diameter showed AUC = 0.960, 100.0% sensitivity and 88.9% specificity with a 53.9 μm cutoff.
AS-OCTA shows greater peri-lesional vessel depth and diameter of malignant lesions compared to benign lesions. This imaging modality provides novel and non-invasive functional vascular parameters that can potentially aid the assessment of ocular surface lesions.
•Malignant lesions showed greater peri-lesional vessel depth and vessel diameter.•AS-OCTA can identify feeder vessels in malignant conjunctival lesions.•AS-OCTA provided novel vascular parameters for ocular surface lesion assessment.•AS-OCTA is a promising non-invasive objective tool to assess ocular surface lesions.</description><identifier>ISSN: 1542-0124</identifier><identifier>ISSN: 1937-5913</identifier><identifier>EISSN: 1937-5913</identifier><identifier>DOI: 10.1016/j.jtos.2021.07.009</identifier><identifier>PMID: 34333154</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; AS-OCTA ; Case-Control Studies ; Conjunctival tumors ; Eye ; Feeder vessel ; Female ; Fluorescein Angiography ; Humans ; Male ; Middle Aged ; OCTA ; Ocular surface neoplasia ; Optical coherence tomography angiography ; Retrospective Studies ; Tomography, Optical Coherence</subject><ispartof>The ocular surface, 2021-10, Vol.22, p.86-93</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c286t-8d5cfddd020e93fd7d58b7b32d935a833bf7819192c57e5ee54fc076fcc7ffe43</citedby><cites>FETCH-LOGICAL-c286t-8d5cfddd020e93fd7d58b7b32d935a833bf7819192c57e5ee54fc076fcc7ffe43</cites><orcidid>0000-0002-9313-2939 ; 0000-0002-8740-2074</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34333154$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Binotti, William W.</creatorcontrib><creatorcontrib>Mills, Huan</creatorcontrib><creatorcontrib>Nosé, Ricardo M.</creatorcontrib><creatorcontrib>Wu, Helen K.</creatorcontrib><creatorcontrib>Duker, Jay S.</creatorcontrib><creatorcontrib>Hamrah, Pedram</creatorcontrib><title>Anterior segment optical coherence tomography angiography in the assessment of ocular surface lesions</title><title>The ocular surface</title><addtitle>Ocul Surf</addtitle><description>Describe the utility of anterior segment optical coherence tomography angiography (AS-OCTA) to assess ocular surface lesions.
Retrospective, case-control study of 10 eyes of 9 patients with malignant lesions and 23 eyes of 22 patients with benign lesions. Lesions included 13 epithelial, 10 pigmented and 10 lymphoid lesions. Graders performed an average of 3 depth and diameter measurements of peri-lesional vessels entering each lesion on AS-OCTA. Statistical models to assess differences between groups accounted for bilateral eye inclusion and lesion thickness (on AS-OCT). Receiver operating characteristic (ROC) curve and area under the curve (AUC) were performed for each parameter.
In the benign and malignant groups, age was 49.5 ± 22.4 and 64.3 ± 10.6 years (p = 0.145) with 45% males and 55% males (p = 0.458), in their respective groups. AS-OCTA showed greater peri-lesional vessel depth and diameter in malignant lesions (315.2 ± 73.0 μm, p < 0.001 and 76.4 ± 18.2 μm, p < 0.001; respectively) compared to benign lesions (199.4 ± 34.1 μm and 44.0 ± 9.4 μm, respectively). Malignant lesions showed deep and dilated peri-lesional vessels, which may represent feeder vessels. Vessel depth showed AUC = 0.980, 90.9% sensitivity and 100.0% specificity with a 236.5 μm cutoff. Vessel diameter showed AUC = 0.960, 100.0% sensitivity and 88.9% specificity with a 53.9 μm cutoff.
AS-OCTA shows greater peri-lesional vessel depth and diameter of malignant lesions compared to benign lesions. This imaging modality provides novel and non-invasive functional vascular parameters that can potentially aid the assessment of ocular surface lesions.
•Malignant lesions showed greater peri-lesional vessel depth and vessel diameter.•AS-OCTA can identify feeder vessels in malignant conjunctival lesions.•AS-OCTA provided novel vascular parameters for ocular surface lesion assessment.•AS-OCTA is a promising non-invasive objective tool to assess ocular surface lesions.</description><subject>Adult</subject><subject>Aged</subject><subject>AS-OCTA</subject><subject>Case-Control Studies</subject><subject>Conjunctival tumors</subject><subject>Eye</subject><subject>Feeder vessel</subject><subject>Female</subject><subject>Fluorescein Angiography</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>OCTA</subject><subject>Ocular surface neoplasia</subject><subject>Optical coherence tomography angiography</subject><subject>Retrospective Studies</subject><subject>Tomography, Optical Coherence</subject><issn>1542-0124</issn><issn>1937-5913</issn><issn>1937-5913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtr3DAUhUVoyGPaP5BF8LIbu3pYlg3ZhJAXBLpp1kIjXc1osK2JrlzIv6-GSbrM6h645xw4HyFXjDaMsu7XrtnliA2nnDVUNZQOJ-SCDULVcmDiW9Gy5TVlvD0nl4g7SkXXUX5GzkUrhCjfCwK3c4YUYqoQNhPMuYr7HKwZKxu3kGC2UOU4xU0y--17ZeZN-NRhrvIWKoMIiMeor6JdRlPKluRNiY6AIc74nZx6MyL8-Lgr8vpw_-fuqX75_fh8d_tSW953ue6dtN45RzmFQXinnOzXai24G4Q0vRBrr3o2sIFbqUACyNZbqjpvrfIeWrEiP4-9-xTfFsCsp4AWxtHMEBfUXEolW0bL-hXhR6tNETGB1_sUJpPeNaP6gFfv9AGvPuDVVOmCt4SuP_qX9QTuf-STZzHcHA1QVv4NkDTacIDoQgKbtYvhq_5_9bKOpg</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Binotti, William W.</creator><creator>Mills, Huan</creator><creator>Nosé, Ricardo M.</creator><creator>Wu, Helen K.</creator><creator>Duker, Jay S.</creator><creator>Hamrah, Pedram</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9313-2939</orcidid><orcidid>https://orcid.org/0000-0002-8740-2074</orcidid></search><sort><creationdate>202110</creationdate><title>Anterior segment optical coherence tomography angiography in the assessment of ocular surface lesions</title><author>Binotti, William W. ; Mills, Huan ; Nosé, Ricardo M. ; Wu, Helen K. ; Duker, Jay S. ; Hamrah, Pedram</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c286t-8d5cfddd020e93fd7d58b7b32d935a833bf7819192c57e5ee54fc076fcc7ffe43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aged</topic><topic>AS-OCTA</topic><topic>Case-Control Studies</topic><topic>Conjunctival tumors</topic><topic>Eye</topic><topic>Feeder vessel</topic><topic>Female</topic><topic>Fluorescein Angiography</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>OCTA</topic><topic>Ocular surface neoplasia</topic><topic>Optical coherence tomography angiography</topic><topic>Retrospective Studies</topic><topic>Tomography, Optical Coherence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Binotti, William W.</creatorcontrib><creatorcontrib>Mills, Huan</creatorcontrib><creatorcontrib>Nosé, Ricardo M.</creatorcontrib><creatorcontrib>Wu, Helen K.</creatorcontrib><creatorcontrib>Duker, Jay S.</creatorcontrib><creatorcontrib>Hamrah, Pedram</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The ocular surface</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Binotti, William W.</au><au>Mills, Huan</au><au>Nosé, Ricardo M.</au><au>Wu, Helen K.</au><au>Duker, Jay S.</au><au>Hamrah, Pedram</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anterior segment optical coherence tomography angiography in the assessment of ocular surface lesions</atitle><jtitle>The ocular surface</jtitle><addtitle>Ocul Surf</addtitle><date>2021-10</date><risdate>2021</risdate><volume>22</volume><spage>86</spage><epage>93</epage><pages>86-93</pages><issn>1542-0124</issn><issn>1937-5913</issn><eissn>1937-5913</eissn><abstract>Describe the utility of anterior segment optical coherence tomography angiography (AS-OCTA) to assess ocular surface lesions.
Retrospective, case-control study of 10 eyes of 9 patients with malignant lesions and 23 eyes of 22 patients with benign lesions. Lesions included 13 epithelial, 10 pigmented and 10 lymphoid lesions. Graders performed an average of 3 depth and diameter measurements of peri-lesional vessels entering each lesion on AS-OCTA. Statistical models to assess differences between groups accounted for bilateral eye inclusion and lesion thickness (on AS-OCT). Receiver operating characteristic (ROC) curve and area under the curve (AUC) were performed for each parameter.
In the benign and malignant groups, age was 49.5 ± 22.4 and 64.3 ± 10.6 years (p = 0.145) with 45% males and 55% males (p = 0.458), in their respective groups. AS-OCTA showed greater peri-lesional vessel depth and diameter in malignant lesions (315.2 ± 73.0 μm, p < 0.001 and 76.4 ± 18.2 μm, p < 0.001; respectively) compared to benign lesions (199.4 ± 34.1 μm and 44.0 ± 9.4 μm, respectively). Malignant lesions showed deep and dilated peri-lesional vessels, which may represent feeder vessels. Vessel depth showed AUC = 0.980, 90.9% sensitivity and 100.0% specificity with a 236.5 μm cutoff. Vessel diameter showed AUC = 0.960, 100.0% sensitivity and 88.9% specificity with a 53.9 μm cutoff.
AS-OCTA shows greater peri-lesional vessel depth and diameter of malignant lesions compared to benign lesions. This imaging modality provides novel and non-invasive functional vascular parameters that can potentially aid the assessment of ocular surface lesions.
•Malignant lesions showed greater peri-lesional vessel depth and vessel diameter.•AS-OCTA can identify feeder vessels in malignant conjunctival lesions.•AS-OCTA provided novel vascular parameters for ocular surface lesion assessment.•AS-OCTA is a promising non-invasive objective tool to assess ocular surface lesions.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34333154</pmid><doi>10.1016/j.jtos.2021.07.009</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-9313-2939</orcidid><orcidid>https://orcid.org/0000-0002-8740-2074</orcidid></addata></record> |
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| subjects | Adult Aged AS-OCTA Case-Control Studies Conjunctival tumors Eye Feeder vessel Female Fluorescein Angiography Humans Male Middle Aged OCTA Ocular surface neoplasia Optical coherence tomography angiography Retrospective Studies Tomography, Optical Coherence |
| title | Anterior segment optical coherence tomography angiography in the assessment of ocular surface lesions |
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