Urine-based regenerative RNA biomarkers for urinary bladder wound healing
This study aimed to investigate the expression of regeneration-related genes in canine urine during bladder repair. Canine urine samples were collected after partial cystectomy. Regenerative mRNA of hypoxia-inducible factor (HIF), vascular endothelial growth factor (VEGF), key stem cell transcriptio...
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| Veröffentlicht in: | Regenerative medicine 2021-08, Vol.16 (8), p.709-718 |
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| container_title | Regenerative medicine |
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| creator | Liu, Chanzhen Zhou, Juan Li, You Lu, Yulei Lu, Haoyuan Wei, Wei Wu, Mingsong Yi, Xianlin |
| description | This study aimed to investigate the expression of regeneration-related genes in canine urine during bladder repair.
Canine urine samples were collected after partial cystectomy. Regenerative mRNA of hypoxia-inducible factor (HIF), vascular endothelial growth factor (VEGF), key stem cell transcription factors and cholinergic signals were detected.
HIF-1α, VEGF, CD44, IL-6 and prominin-1 expression in canine urine after partial cystectomy exhibited two similar peaks at ∼2 weeks. HIF-1α and VEGF expression were higher in the afternoon than the morning. The expression of key stem cell transcription factors and cholinergic signals also exhibited a rhythm along with bladder healing.
The expression of HIF-1α, VEGF, key stem cell transcription factors and cholinergic signals exhibited a time curve distribution during canine bladder healing. The expression trend of some regenerative genes was similar during bladder healing, and a cooperative effect may exist. |
| doi_str_mv | 10.2217/rme-2021-0057 |
| format | Article |
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Canine urine samples were collected after partial cystectomy. Regenerative mRNA of hypoxia-inducible factor (HIF), vascular endothelial growth factor (VEGF), key stem cell transcription factors and cholinergic signals were detected.
HIF-1α, VEGF, CD44, IL-6 and prominin-1 expression in canine urine after partial cystectomy exhibited two similar peaks at ∼2 weeks. HIF-1α and VEGF expression were higher in the afternoon than the morning. The expression of key stem cell transcription factors and cholinergic signals also exhibited a rhythm along with bladder healing.
The expression of HIF-1α, VEGF, key stem cell transcription factors and cholinergic signals exhibited a time curve distribution during canine bladder healing. The expression trend of some regenerative genes was similar during bladder healing, and a cooperative effect may exist.</description><identifier>ISSN: 1746-0751</identifier><identifier>EISSN: 1746-076X</identifier><identifier>DOI: 10.2217/rme-2021-0057</identifier><language>eng</language><publisher>Future Medicine Ltd</publisher><subject>bladder injury ; cholinergic receptor ; regeneration ; stem cell ; urine</subject><ispartof>Regenerative medicine, 2021-08, Vol.16 (8), p.709-718</ispartof><rights>The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c315t-aa19dc311abc0184627b64aafe44969090afc0f47226814b74770041081f3df93</cites><orcidid>0000-0002-3615-3784</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Liu, Chanzhen</creatorcontrib><creatorcontrib>Zhou, Juan</creatorcontrib><creatorcontrib>Li, You</creatorcontrib><creatorcontrib>Lu, Yulei</creatorcontrib><creatorcontrib>Lu, Haoyuan</creatorcontrib><creatorcontrib>Wei, Wei</creatorcontrib><creatorcontrib>Wu, Mingsong</creatorcontrib><creatorcontrib>Yi, Xianlin</creatorcontrib><title>Urine-based regenerative RNA biomarkers for urinary bladder wound healing</title><title>Regenerative medicine</title><description>This study aimed to investigate the expression of regeneration-related genes in canine urine during bladder repair.
Canine urine samples were collected after partial cystectomy. Regenerative mRNA of hypoxia-inducible factor (HIF), vascular endothelial growth factor (VEGF), key stem cell transcription factors and cholinergic signals were detected.
HIF-1α, VEGF, CD44, IL-6 and prominin-1 expression in canine urine after partial cystectomy exhibited two similar peaks at ∼2 weeks. HIF-1α and VEGF expression were higher in the afternoon than the morning. The expression of key stem cell transcription factors and cholinergic signals also exhibited a rhythm along with bladder healing.
The expression of HIF-1α, VEGF, key stem cell transcription factors and cholinergic signals exhibited a time curve distribution during canine bladder healing. The expression trend of some regenerative genes was similar during bladder healing, and a cooperative effect may exist.</description><subject>bladder injury</subject><subject>cholinergic receptor</subject><subject>regeneration</subject><subject>stem cell</subject><subject>urine</subject><issn>1746-0751</issn><issn>1746-076X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kE1LAzEQhoMoWKtH7zl6iSbZbLJ7LMWPQlEQC95CNjup0f2oya7Sf2_KijdP8w4878A8CF0yes05UzehBcIpZ4TSXB2hGVNCEqrk6_FfztkpOovxPRFZkfMZWm2C74BUJkKNA2yhg2AG_wX4-XGBK9-3JnxAiNj1AY-JNWGPq8bUNQT83Y9djd_ANL7bnqMTZ5oIF79zjjZ3ty_LB7J-ul8tF2tiM5YPxBhW1ikyU1nKCiG5qqQwxoEQpSxpSY2z1AnFuSyYqJRQilLBaMFcVrsym6Or6e4u9J8jxEG3PlpoGtNBP0bN81zlgkrJE0om1IY-xgBO74JPD-01o_qgTCdl-qBMH5Qlvpx4Nw5jgGg9dBb0tLVQe5tc_dP9AW0Ocf4</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Liu, Chanzhen</creator><creator>Zhou, Juan</creator><creator>Li, You</creator><creator>Lu, Yulei</creator><creator>Lu, Haoyuan</creator><creator>Wei, Wei</creator><creator>Wu, Mingsong</creator><creator>Yi, Xianlin</creator><general>Future Medicine Ltd</general><scope>FUMOA</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3615-3784</orcidid></search><sort><creationdate>20210801</creationdate><title>Urine-based regenerative RNA biomarkers for urinary bladder wound healing</title><author>Liu, Chanzhen ; Zhou, Juan ; Li, You ; Lu, Yulei ; Lu, Haoyuan ; Wei, Wei ; Wu, Mingsong ; Yi, Xianlin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-aa19dc311abc0184627b64aafe44969090afc0f47226814b74770041081f3df93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>bladder injury</topic><topic>cholinergic receptor</topic><topic>regeneration</topic><topic>stem cell</topic><topic>urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Chanzhen</creatorcontrib><creatorcontrib>Zhou, Juan</creatorcontrib><creatorcontrib>Li, You</creatorcontrib><creatorcontrib>Lu, Yulei</creatorcontrib><creatorcontrib>Lu, Haoyuan</creatorcontrib><creatorcontrib>Wei, Wei</creatorcontrib><creatorcontrib>Wu, Mingsong</creatorcontrib><creatorcontrib>Yi, Xianlin</creatorcontrib><collection>Future Medicine (Open Access)</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Regenerative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Chanzhen</au><au>Zhou, Juan</au><au>Li, You</au><au>Lu, Yulei</au><au>Lu, Haoyuan</au><au>Wei, Wei</au><au>Wu, Mingsong</au><au>Yi, Xianlin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urine-based regenerative RNA biomarkers for urinary bladder wound healing</atitle><jtitle>Regenerative medicine</jtitle><date>2021-08-01</date><risdate>2021</risdate><volume>16</volume><issue>8</issue><spage>709</spage><epage>718</epage><pages>709-718</pages><issn>1746-0751</issn><eissn>1746-076X</eissn><abstract>This study aimed to investigate the expression of regeneration-related genes in canine urine during bladder repair.
Canine urine samples were collected after partial cystectomy. Regenerative mRNA of hypoxia-inducible factor (HIF), vascular endothelial growth factor (VEGF), key stem cell transcription factors and cholinergic signals were detected.
HIF-1α, VEGF, CD44, IL-6 and prominin-1 expression in canine urine after partial cystectomy exhibited two similar peaks at ∼2 weeks. HIF-1α and VEGF expression were higher in the afternoon than the morning. The expression of key stem cell transcription factors and cholinergic signals also exhibited a rhythm along with bladder healing.
The expression of HIF-1α, VEGF, key stem cell transcription factors and cholinergic signals exhibited a time curve distribution during canine bladder healing. The expression trend of some regenerative genes was similar during bladder healing, and a cooperative effect may exist.</abstract><pub>Future Medicine Ltd</pub><doi>10.2217/rme-2021-0057</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-3615-3784</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | PubMed Central |
| subjects | bladder injury cholinergic receptor regeneration stem cell urine |
| title | Urine-based regenerative RNA biomarkers for urinary bladder wound healing |
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