Inhibition of AMPA (α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionate) Receptor Reduces Acute Blood–Brain Barrier Disruption After Subarachnoid Hemorrhage in Mice

Activation of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor (AMPAR) is thought to cause acute brain injury, but the role remains poorly understood in subarachnoid hemorrhage (SAH). This study was conducted to evaluate if AMPAR activation induces acute blood–brain barrier (BBB) disruptio...

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Veröffentlicht in:	Translational stroke research 2022-04, Vol.13 (2), p.326-337
Hauptverfasser:	Kawakita, Fumihiro, Kanamaru, Hideki, Asada, Reona, Imanaka-Yoshida, Kyoko, Yoshida, Toshimichi, Suzuki, Hidenori
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - metabolism alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - therapeutic use Animals Biomedical and Life Sciences Biomedicine Blood clots Blood-Brain Barrier - metabolism Brain Edema - drug therapy Brain Edema - etiology Brain Edema - prevention & control Cardiology Carotid arteries Convulsions & seizures Drug dosages Electroencephalography Endothelial Cells - metabolism Female Isoxazoles - metabolism Isoxazoles - pharmacology Isoxazoles - therapeutic use Kinases Laboratory animals Male Mice Mice, Inbred C57BL Neurology Neurosciences Neurosurgery Original Article Permeability Propionates - metabolism Propionates - pharmacology Propionates - therapeutic use Stroke Subarachnoid Hemorrhage - complications Subarachnoid Hemorrhage - drug therapy Tenascin - metabolism Tenascin - pharmacology Tenascin - therapeutic use Traumatic brain injury Vascular Surgery Veins & arteries
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