Orthogonal targeting of osteoclasts and myeloma cells for radionuclide stimulated dynamic therapy induces multidimensional cell death pathways

Rationale: Multiple myeloma (MM) is a multifocal malignancy of bone marrow plasma cells, characterized by vicious cycles of remission and relapse that eventually culminate in death. The disease remains mostly incurable largely due to the complex interactions between the bone microenvironment (BME) a...

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Veröffentlicht in:	Theranostics 2021-01, Vol.11 (16), p.7735-7754
Hauptverfasser:	Zheleznyak, Alexander, Mixdorf, Matthew, Marsala, Lynne, Prior, Julie, Yang, Xiaoxia, Cui, Grace, Xu, Baogang, Fletcher, Steven, Fontana, Francesca, Lanza, Gregory, Achilefu, Samuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Apoptosis Bone cancer Bone marrow Cell death Drug dosages Ligands Multiple myeloma Plasma Polyethylene glycol Radiation Reactive oxygen species Research Paper Surfactants
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