Unraveling Congener-Specific Transfer of Non-Dioxin-Like Polychlorinated Biphenyls (ndl-PCBs) from Feed into Chicken Meat

Non-dioxin-like polychlorinated biphenyls (ndl-PCBs) are a subclass of persistent bioaccumulative pollutants able to enter the food chain. We investigated the transfer of ndl-PCBs from contaminated feed into meat and liver of fattening chickens. A total of 48 chicks were divided into five treatment...

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Veröffentlicht in:Environmental science & technology 2021-08, Vol.55 (16), p.11080-11090
Hauptverfasser: Ohlhoff, Britta, Savvateeva, Daria, Bernsmann, Thorsten, Spolders, Markus, Jahnke, Anne, Lüth, Anja, Lahrssen-Wiederholt, Monika, Numata, Jorge, Pieper, Robert
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container_end_page 11090
container_issue 16
container_start_page 11080
container_title Environmental science & technology
container_volume 55
creator Ohlhoff, Britta
Savvateeva, Daria
Bernsmann, Thorsten
Spolders, Markus
Jahnke, Anne
Lüth, Anja
Lahrssen-Wiederholt, Monika
Numata, Jorge
Pieper, Robert
description Non-dioxin-like polychlorinated biphenyls (ndl-PCBs) are a subclass of persistent bioaccumulative pollutants able to enter the food chain. We investigated the transfer of ndl-PCBs from contaminated feed into meat and liver of fattening chickens. A total of 48 chicks were divided into five treatment and one control groups. Treated animals were fed with contaminated diets (11.7 ± 0.4 μg/kg sum of indicator ndl-PCBs; 88% dry matter (DM)) before slaughter for different subperiods of time: 16, 23, 28, 32, and 36 days for groups 1–5, respectively. One day after the end of each subperiod, three animals per group were slaughtered to determine the congener-specific ndl-PCB content. All remaining animals were fed the control feed until slaughter on day 37 to probe depuration. We used these data to generate congener-specific physiologically based toxicokinetic (PBTK) models for indicator ndl-PCBs. The models show that PCBs 28, 138, 153, and 180 form a more slowly eliminated cluster (with an observed transfer rate into meat over 74% and observed half-lives over 8.7 days) than PCBs 52 and 101 (with a transfer rate under 13% and half-lives under 2.6 days). Our simulations show that ndl-PCB levels in feed lower than 3.9 (long 56-day) or 4.4 μg/kg (short 37-day fattening period) would be necessary to ensure the current maximum level in muscle meat (fat basis), according to EU Regulations 1881/2006 and 1259/2011. The PBTK models are made available in the Python and Food Safety Knowledge Exchange formats.
doi_str_mv 10.1021/acs.est.1c02650
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ispartof Environmental science & technology, 2021-08, Vol.55 (16), p.11080-11090
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source American Chemical Society Journals
subjects Animals
Bioaccumulation
Chickens
Congeners
Contaminants in Aquatic and Terrestrial Environments
Depuration
Dioxins
Dry matter
Feeds
Food chains
Food contamination
Half-life
Meat
Muscles
PCB
Pollutants
Polychlorinated biphenyls
Slaughter
title Unraveling Congener-Specific Transfer of Non-Dioxin-Like Polychlorinated Biphenyls (ndl-PCBs) from Feed into Chicken Meat
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