Repurposing proscillaridin A in combination with decitabine against embryonal rhabdomyosarcoma RD cells

Purpose Embryonal rhabdomyosarcoma (eRMS) is the most common type of rhabdomyosarcoma in children. eRMS is characterized by malignant skeletal muscle cells driven by hyperactivation of several oncogenic pathways including the MYC pathway. Targeting MYC in cancer has been extremely challenging. Recen...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2021-11, Vol.88 (5), p.845-856
Hauptverfasser:	Huot, Marielle, Caron, Maxime, Richer, Chantal, Djibo, Rahinatou, Najmanovich, Rafael, St-Onge, Pascal, Sinnett, Daniel, Raynal, Noël J. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-aza-2'-deoxycytidine Acetylation Acetylation - drug effects Anticancer properties Antineoplastic Combined Chemotherapy Protocols - pharmacology Antitumor activity Cancer Cancer Research Cell cycle Cell Line, Tumor Cell Self Renewal - drug effects Cell self-renewal Chromatin Colon Colon cancer Congestive heart failure Decitabine - administration & dosage Deoxyribonucleic acid DNA Drug Repositioning Epigenetics Evaluation Gene expression Gene Expression Regulation, Neoplastic - drug effects Gene sequencing Histones Histones - metabolism Humans Immunoprecipitation Investigations Leukemia Lysine Lysine - metabolism Medicine Medicine & Public Health Muscles Myc protein Neoplasm Proteins Oncology Original Article Pharmacology/Toxicology Post-translation Promoter Regions, Genetic - drug effects Proscillaridin - administration & dosage Proscillaridin - pharmacology Protein expression Proteins Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Rhabdomyosarcoma Rhabdomyosarcoma, Embryonal - drug therapy Rhabdomyosarcoma, Embryonal - genetics Rhabdomyosarcoma, Embryonal - pathology Skeletal muscle Transcription Transcriptomics
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