Potential therapeutics using tumor-secreted lactate in nonsmall cell lung cancer

•Non-small cell lung cancer (NSCLC) frequently presents genetic mutuations.•NSCLC upregulates glucose metabolism and subsequent accumulates lactate.•Lactate as key molecule leads various phenomena in tumor microenvironment.•Lactate oxidase (LOX) can directly oxidize tumor-secreted lactate.•Consuming...

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Veröffentlicht in:	Drug discovery today 2021-11, Vol.26 (11), p.2508-2514
Hauptverfasser:	Liao, Zi-Xian, Kempson, Ivan M., Hsieh, Chia-Chen, Tseng, S.-Ja, Yang, Pan-Chyr
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaplastic Lymphoma Kinase - genetics Animals Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Citric Acid Cycle Drug Resistance, Neoplasm Genes, erbB-1 - genetics Glucose - metabolism Humans Immune Checkpoint Inhibitors - therapeutic use L-Lactate Dehydrogenase - antagonists & inhibitors Lactate Lactate oxidase Lactic Acid - metabolism Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism Metabolic Networks and Pathways Mixed Function Oxygenases - therapeutic use Molecular Targeted Therapy Nanoparticles Nonsmall cell lung cancer NSCLC Protein Kinase Inhibitors - therapeutic use Proto-Oncogene Proteins p21(ras) - genetics Tumor Microenvironment
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