Autophagic degradation of NOXA underlies stromal cell-mediated resistance to proteasome inhibitors in mantle cell lymphoma

[Display omitted] •MCL cells acquire drug resistance via interaction with stromal cells.•Bortezomib induces cell death via stabilization of the proapoptotic protein NOXA.•Autophagic degradation of NOXA is a mechanism of BTZ resistance in MCL cells.•Stroma-derived humoral factors promote selective au...

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Veröffentlicht in:	Leukemia research 2021-12, Vol.111, p.106672-106672, Article 106672
Hauptverfasser:	Kuroda, Yoshiaki, Koyama, Daisuke, Kikuchi, Jiro, Mori, Shigehisa, Ichinohe, Tatsuo, Furukawa, Yusuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Autophagy Cell Proliferation Drug resistance Drug Resistance, Neoplasm Humans Lymph Nodes - drug effects Lymph Nodes - metabolism Lymph Nodes - pathology Lymphoma, Mantle-Cell - drug therapy Lymphoma, Mantle-Cell - metabolism Lymphoma, Mantle-Cell - pathology Male Mantle cell lymphoma Mice Mice, Inbred NOD Mice, SCID Proteasome inhibitors Proteasome Inhibitors - pharmacology Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Stroma Stromal Cells - drug effects Stromal Cells - metabolism Stromal Cells - pathology Tumor Cells, Cultured Tumor Microenvironment Xenograft Model Antitumor Assays
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