The effects of amino acid/protein supplementation in patients undergoing hemodialysis: A systematic review and meta-analysis of randomized controlled trials
We evaluated the efficacy of the intervention consisting of amino acid/protein supplementation on muscle mass, muscle strength and physical function in patients on hemodialysis. This systematic review and meta-analysis identified potential studies through a systematic search of 4 electronic database...
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| Veröffentlicht in: | Clinical nutrition ESPEN 2021-08, Vol.44, p.114-121 |
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| creator | Matsuzawa, Ryota Yamamoto, Shohei Suzuki, Yuta Abe, Yoshifumi Harada, Manae Shimoda, Takahiro Imamura, Keigo Yamabe, Sachi Ito, Haruka Yoshikoshi, Shun Imai, Hiroto Onoe, Hinano Matsunaga, Atsuhiko Tamaki, Akira |
| description | We evaluated the efficacy of the intervention consisting of amino acid/protein supplementation on muscle mass, muscle strength and physical function in patients on hemodialysis.
This systematic review and meta-analysis identified potential studies through a systematic search of 4 electronic databases and references from eligible studies from database inception to August 2020. We included only randomized controlled trials reporting the efficacy of amino acid/protein supplementation on muscle mass, muscle strength and physical function in patients on hemodialysis.
Of 6529 unique citation records, 4 studies including 243 participants were selected for inclusion in the meta-analysis. Although there were no significant differences in muscle mass and muscle strength between the intervention and control groups, amino acid/protein supplementation was shown to significantly improve physical function (shuttle walk, MD 32.7, 95% CI 21.7 to 43.7, P |
| doi_str_mv | 10.1016/j.clnesp.2021.04.027 |
| format | Article |
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This systematic review and meta-analysis identified potential studies through a systematic search of 4 electronic databases and references from eligible studies from database inception to August 2020. We included only randomized controlled trials reporting the efficacy of amino acid/protein supplementation on muscle mass, muscle strength and physical function in patients on hemodialysis.
Of 6529 unique citation records, 4 studies including 243 participants were selected for inclusion in the meta-analysis. Although there were no significant differences in muscle mass and muscle strength between the intervention and control groups, amino acid/protein supplementation was shown to significantly improve physical function (shuttle walk, MD 32.7, 95% CI 21.7 to 43.7, P < 0.001; gait speed, MD 0.07, 95% CI 0.01 to 0.13, P = 0.02; timed up and go, MD -0.42, 95% CI -0.68 to −0.15, P = 0.002) in patients on hemodialysis.
We confirmed the positive effect of amino acid/protein supplementation on physical function in people undergoing hemodialysis. However, there is still insufficient evidence, and more rigorously designed randomized controlled trials with high quality are needed.</description><identifier>ISSN: 2405-4577</identifier><identifier>EISSN: 2405-4577</identifier><identifier>DOI: 10.1016/j.clnesp.2021.04.027</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>BCAA ; Dialysis ; Frail ; Malnutrition ; Protein energy wasting ; Sarcopenia</subject><ispartof>Clinical nutrition ESPEN, 2021-08, Vol.44, p.114-121</ispartof><rights>2021 European Society for Clinical Nutrition and Metabolism</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-feb2df5e8feaa166b6fd0143b8287e47fe175769980ab84b0b999dc7d17b8e303</citedby><cites>FETCH-LOGICAL-c405t-feb2df5e8feaa166b6fd0143b8287e47fe175769980ab84b0b999dc7d17b8e303</cites><orcidid>0000-0002-6440-670X ; 0000-0001-6503-8577 ; 0000-0002-9406-4691 ; 0000-0003-0190-707X ; 0000-0003-4165-7626 ; 0000-0003-1999-3834</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Matsuzawa, Ryota</creatorcontrib><creatorcontrib>Yamamoto, Shohei</creatorcontrib><creatorcontrib>Suzuki, Yuta</creatorcontrib><creatorcontrib>Abe, Yoshifumi</creatorcontrib><creatorcontrib>Harada, Manae</creatorcontrib><creatorcontrib>Shimoda, Takahiro</creatorcontrib><creatorcontrib>Imamura, Keigo</creatorcontrib><creatorcontrib>Yamabe, Sachi</creatorcontrib><creatorcontrib>Ito, Haruka</creatorcontrib><creatorcontrib>Yoshikoshi, Shun</creatorcontrib><creatorcontrib>Imai, Hiroto</creatorcontrib><creatorcontrib>Onoe, Hinano</creatorcontrib><creatorcontrib>Matsunaga, Atsuhiko</creatorcontrib><creatorcontrib>Tamaki, Akira</creatorcontrib><title>The effects of amino acid/protein supplementation in patients undergoing hemodialysis: A systematic review and meta-analysis of randomized controlled trials</title><title>Clinical nutrition ESPEN</title><description>We evaluated the efficacy of the intervention consisting of amino acid/protein supplementation on muscle mass, muscle strength and physical function in patients on hemodialysis.
This systematic review and meta-analysis identified potential studies through a systematic search of 4 electronic databases and references from eligible studies from database inception to August 2020. We included only randomized controlled trials reporting the efficacy of amino acid/protein supplementation on muscle mass, muscle strength and physical function in patients on hemodialysis.
Of 6529 unique citation records, 4 studies including 243 participants were selected for inclusion in the meta-analysis. Although there were no significant differences in muscle mass and muscle strength between the intervention and control groups, amino acid/protein supplementation was shown to significantly improve physical function (shuttle walk, MD 32.7, 95% CI 21.7 to 43.7, P < 0.001; gait speed, MD 0.07, 95% CI 0.01 to 0.13, P = 0.02; timed up and go, MD -0.42, 95% CI -0.68 to −0.15, P = 0.002) in patients on hemodialysis.
We confirmed the positive effect of amino acid/protein supplementation on physical function in people undergoing hemodialysis. However, there is still insufficient evidence, and more rigorously designed randomized controlled trials with high quality are needed.</description><subject>BCAA</subject><subject>Dialysis</subject><subject>Frail</subject><subject>Malnutrition</subject><subject>Protein energy wasting</subject><subject>Sarcopenia</subject><issn>2405-4577</issn><issn>2405-4577</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9UcFO3DAUjKoiFQF_0IOPvSTYXidOekBCiAISEpflbDn2M3iV2KntpVq-pR_bt0oPnDi98dPMs2amqr4z2jDKustdY6YAeWk45ayhoqFcfqlOuaBtLVopv37A36qLnHeUom4YBKOn1d_tKxBwDkzJJDqiZx8i0cbbyyXFAj6QvF-WCWYIRRcfA8HVggjfmeyDhfQSfXghrzBH6_V0yD7_JNckH3KBGYmGJHjz8IfoYMkMRdc6rLTjhwm3cfbvYImJoaQ4TQhLwkv5vDpxOODi_zyrnn_dbm_u68enu4eb68faoLFSOxi5dS30DrRmXTd2zlImNmPPewlCOmCylei4p3rsxUjHYRiskZbJsYcN3ZxVP9a7aPn3HnJRs88GpkkHiPuseNtKzoe-40gVK9WkmHMCp5bkZ50OilF17EPt1NqHOvahqFDYB8quVhmgDQwjqWwwQQPWJ4xe2eg_P_APAc2ahQ</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Matsuzawa, Ryota</creator><creator>Yamamoto, Shohei</creator><creator>Suzuki, Yuta</creator><creator>Abe, Yoshifumi</creator><creator>Harada, Manae</creator><creator>Shimoda, Takahiro</creator><creator>Imamura, Keigo</creator><creator>Yamabe, Sachi</creator><creator>Ito, Haruka</creator><creator>Yoshikoshi, Shun</creator><creator>Imai, Hiroto</creator><creator>Onoe, Hinano</creator><creator>Matsunaga, Atsuhiko</creator><creator>Tamaki, Akira</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6440-670X</orcidid><orcidid>https://orcid.org/0000-0001-6503-8577</orcidid><orcidid>https://orcid.org/0000-0002-9406-4691</orcidid><orcidid>https://orcid.org/0000-0003-0190-707X</orcidid><orcidid>https://orcid.org/0000-0003-4165-7626</orcidid><orcidid>https://orcid.org/0000-0003-1999-3834</orcidid></search><sort><creationdate>202108</creationdate><title>The effects of amino acid/protein supplementation in patients undergoing hemodialysis: A systematic review and meta-analysis of randomized controlled trials</title><author>Matsuzawa, Ryota ; Yamamoto, Shohei ; Suzuki, Yuta ; Abe, Yoshifumi ; Harada, Manae ; Shimoda, Takahiro ; Imamura, Keigo ; Yamabe, Sachi ; Ito, Haruka ; Yoshikoshi, Shun ; Imai, Hiroto ; Onoe, Hinano ; Matsunaga, Atsuhiko ; Tamaki, Akira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-feb2df5e8feaa166b6fd0143b8287e47fe175769980ab84b0b999dc7d17b8e303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>BCAA</topic><topic>Dialysis</topic><topic>Frail</topic><topic>Malnutrition</topic><topic>Protein energy wasting</topic><topic>Sarcopenia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsuzawa, Ryota</creatorcontrib><creatorcontrib>Yamamoto, Shohei</creatorcontrib><creatorcontrib>Suzuki, Yuta</creatorcontrib><creatorcontrib>Abe, Yoshifumi</creatorcontrib><creatorcontrib>Harada, Manae</creatorcontrib><creatorcontrib>Shimoda, Takahiro</creatorcontrib><creatorcontrib>Imamura, Keigo</creatorcontrib><creatorcontrib>Yamabe, Sachi</creatorcontrib><creatorcontrib>Ito, Haruka</creatorcontrib><creatorcontrib>Yoshikoshi, Shun</creatorcontrib><creatorcontrib>Imai, Hiroto</creatorcontrib><creatorcontrib>Onoe, Hinano</creatorcontrib><creatorcontrib>Matsunaga, Atsuhiko</creatorcontrib><creatorcontrib>Tamaki, Akira</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nutrition ESPEN</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsuzawa, Ryota</au><au>Yamamoto, Shohei</au><au>Suzuki, Yuta</au><au>Abe, Yoshifumi</au><au>Harada, Manae</au><au>Shimoda, Takahiro</au><au>Imamura, Keigo</au><au>Yamabe, Sachi</au><au>Ito, Haruka</au><au>Yoshikoshi, Shun</au><au>Imai, Hiroto</au><au>Onoe, Hinano</au><au>Matsunaga, Atsuhiko</au><au>Tamaki, Akira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of amino acid/protein supplementation in patients undergoing hemodialysis: A systematic review and meta-analysis of randomized controlled trials</atitle><jtitle>Clinical nutrition ESPEN</jtitle><date>2021-08</date><risdate>2021</risdate><volume>44</volume><spage>114</spage><epage>121</epage><pages>114-121</pages><issn>2405-4577</issn><eissn>2405-4577</eissn><abstract>We evaluated the efficacy of the intervention consisting of amino acid/protein supplementation on muscle mass, muscle strength and physical function in patients on hemodialysis.
This systematic review and meta-analysis identified potential studies through a systematic search of 4 electronic databases and references from eligible studies from database inception to August 2020. We included only randomized controlled trials reporting the efficacy of amino acid/protein supplementation on muscle mass, muscle strength and physical function in patients on hemodialysis.
Of 6529 unique citation records, 4 studies including 243 participants were selected for inclusion in the meta-analysis. Although there were no significant differences in muscle mass and muscle strength between the intervention and control groups, amino acid/protein supplementation was shown to significantly improve physical function (shuttle walk, MD 32.7, 95% CI 21.7 to 43.7, P < 0.001; gait speed, MD 0.07, 95% CI 0.01 to 0.13, P = 0.02; timed up and go, MD -0.42, 95% CI -0.68 to −0.15, P = 0.002) in patients on hemodialysis.
We confirmed the positive effect of amino acid/protein supplementation on physical function in people undergoing hemodialysis. However, there is still insufficient evidence, and more rigorously designed randomized controlled trials with high quality are needed.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.clnesp.2021.04.027</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6440-670X</orcidid><orcidid>https://orcid.org/0000-0001-6503-8577</orcidid><orcidid>https://orcid.org/0000-0002-9406-4691</orcidid><orcidid>https://orcid.org/0000-0003-0190-707X</orcidid><orcidid>https://orcid.org/0000-0003-4165-7626</orcidid><orcidid>https://orcid.org/0000-0003-1999-3834</orcidid></addata></record> |
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| subjects | BCAA Dialysis Frail Malnutrition Protein energy wasting Sarcopenia |
| title | The effects of amino acid/protein supplementation in patients undergoing hemodialysis: A systematic review and meta-analysis of randomized controlled trials |
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