The role of interleukin‐1β in the immune response to contact allergens
Interleukin‐1β (IL‐1β) is an important pro‐inflammatory cytokine that has an effect on almost every cell lineage in the body. By blocking IL‐1β and investigating the IL‐1β signaling pathway, several studies have demonstrated a central role of IL‐1β in the response to contact allergens. This review s...
Gespeichert in:
| Veröffentlicht in: | Contact dermatitis 2021-10, Vol.85 (4), p.387-397 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 397 |
|---|---|
| container_issue | 4 |
| container_start_page | 387 |
| container_title | Contact dermatitis |
| container_volume | 85 |
| creator | Yeung, Kelvin Mraz, Veronika Geisler, Carsten Skov, Lone Bonefeld, Charlotte M. |
| description | Interleukin‐1β (IL‐1β) is an important pro‐inflammatory cytokine that has an effect on almost every cell lineage in the body. By blocking IL‐1β and investigating the IL‐1β signaling pathway, several studies have demonstrated a central role of IL‐1β in the response to contact allergens. This review summarizes the current literature regarding the basic immunological mechanisms mediated by IL‐1β in the different phases of allergic contact dermatitis (ACD) and highlights potential IL‐1β‐targeted treatment options, which in the future may be relevant in the treatment of patients with ACD. This review is based primarily on studies using various mouse models and human in vitro studies, since clinical studies on the effect of IL‐1β in ACD are lacking. |
| doi_str_mv | 10.1111/cod.13955 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2557229062</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2573322424</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3885-fb7515bfae11a64f0d5814a34f08853f479c6f4bba01e1500fcdee9a3c16b38f3</originalsourceid><addsrcrecordid>eNp10EtOwzAQBmALgWh5LLgAisQGFmk9fiTpEpWnVKkbWEeOO4aUJC52ItQdR-AsHIRDcBIMARZIeDOW_enX6CfkAOgIwhlruxgBn0i5QYaQUBpTyZNNMqRAZQxZygdkx_slpZAIlm2TAReciZTBkFzf3GPkbIWRNVHZtOgq7B7K5v35Bd5ew0vUBlDWddcEh35lG49RayNtm1bpNlJVhe4OG79HtoyqPO5_z11ye3F-M72KZ_PL6-npLNY8y2RsilSCLIxCAJUIQxcyA6F4uIVvbkQ60YkRRaEoIEhKjV4gThTXkBQ8M3yXHPe5K2cfO_RtXpdeY1WpBm3ncyZlytiEJizQoz90aTvXhO2CSjlnTDAR1EmvtLPeOzT5ypW1cuscaP7Zbx76zb_6DfbwO7Eralz8yp9CAxj34KmscP1_Uj6dn_WRH2VxhK0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2573322424</pqid></control><display><type>article</type><title>The role of interleukin‐1β in the immune response to contact allergens</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Yeung, Kelvin ; Mraz, Veronika ; Geisler, Carsten ; Skov, Lone ; Bonefeld, Charlotte M.</creator><creatorcontrib>Yeung, Kelvin ; Mraz, Veronika ; Geisler, Carsten ; Skov, Lone ; Bonefeld, Charlotte M.</creatorcontrib><description>Interleukin‐1β (IL‐1β) is an important pro‐inflammatory cytokine that has an effect on almost every cell lineage in the body. By blocking IL‐1β and investigating the IL‐1β signaling pathway, several studies have demonstrated a central role of IL‐1β in the response to contact allergens. This review summarizes the current literature regarding the basic immunological mechanisms mediated by IL‐1β in the different phases of allergic contact dermatitis (ACD) and highlights potential IL‐1β‐targeted treatment options, which in the future may be relevant in the treatment of patients with ACD. This review is based primarily on studies using various mouse models and human in vitro studies, since clinical studies on the effect of IL‐1β in ACD are lacking.</description><identifier>ISSN: 0105-1873</identifier><identifier>EISSN: 1600-0536</identifier><identifier>DOI: 10.1111/cod.13955</identifier><identifier>PMID: 34324721</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Allergens ; Allergens - immunology ; allergic contact dermatitis ; Animal models ; Animals ; Cell lineage ; Contact dermatitis ; Cytokines ; Dermatitis, Allergic Contact - drug therapy ; Dermatitis, Allergic Contact - immunology ; Dermatitis, Atopic - drug therapy ; Dermatitis, Atopic - immunology ; Dermatitis, Irritant - drug therapy ; Dermatitis, Irritant - immunology ; Disease Models, Animal ; Eczema ; Humans ; Immune response ; immunology ; Inflammation ; Interleukin-1beta - antagonists & inhibitors ; Interleukin-1beta - immunology ; interleukin‐1β ; Receptors, Interleukin-1 - antagonists & inhibitors ; Receptors, Interleukin-1 - immunology ; Signal Transduction ; T cells</subject><ispartof>Contact dermatitis, 2021-10, Vol.85 (4), p.387-397</ispartof><rights>2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3885-fb7515bfae11a64f0d5814a34f08853f479c6f4bba01e1500fcdee9a3c16b38f3</citedby><cites>FETCH-LOGICAL-c3885-fb7515bfae11a64f0d5814a34f08853f479c6f4bba01e1500fcdee9a3c16b38f3</cites><orcidid>0000-0001-6083-3475 ; 0000-0002-8472-0771 ; 0000-0002-0523-6229</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcod.13955$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcod.13955$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27915,27916,45565,45566</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34324721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yeung, Kelvin</creatorcontrib><creatorcontrib>Mraz, Veronika</creatorcontrib><creatorcontrib>Geisler, Carsten</creatorcontrib><creatorcontrib>Skov, Lone</creatorcontrib><creatorcontrib>Bonefeld, Charlotte M.</creatorcontrib><title>The role of interleukin‐1β in the immune response to contact allergens</title><title>Contact dermatitis</title><addtitle>Contact Dermatitis</addtitle><description>Interleukin‐1β (IL‐1β) is an important pro‐inflammatory cytokine that has an effect on almost every cell lineage in the body. By blocking IL‐1β and investigating the IL‐1β signaling pathway, several studies have demonstrated a central role of IL‐1β in the response to contact allergens. This review summarizes the current literature regarding the basic immunological mechanisms mediated by IL‐1β in the different phases of allergic contact dermatitis (ACD) and highlights potential IL‐1β‐targeted treatment options, which in the future may be relevant in the treatment of patients with ACD. This review is based primarily on studies using various mouse models and human in vitro studies, since clinical studies on the effect of IL‐1β in ACD are lacking.</description><subject>Allergens</subject><subject>Allergens - immunology</subject><subject>allergic contact dermatitis</subject><subject>Animal models</subject><subject>Animals</subject><subject>Cell lineage</subject><subject>Contact dermatitis</subject><subject>Cytokines</subject><subject>Dermatitis, Allergic Contact - drug therapy</subject><subject>Dermatitis, Allergic Contact - immunology</subject><subject>Dermatitis, Atopic - drug therapy</subject><subject>Dermatitis, Atopic - immunology</subject><subject>Dermatitis, Irritant - drug therapy</subject><subject>Dermatitis, Irritant - immunology</subject><subject>Disease Models, Animal</subject><subject>Eczema</subject><subject>Humans</subject><subject>Immune response</subject><subject>immunology</subject><subject>Inflammation</subject><subject>Interleukin-1beta - antagonists & inhibitors</subject><subject>Interleukin-1beta - immunology</subject><subject>interleukin‐1β</subject><subject>Receptors, Interleukin-1 - antagonists & inhibitors</subject><subject>Receptors, Interleukin-1 - immunology</subject><subject>Signal Transduction</subject><subject>T cells</subject><issn>0105-1873</issn><issn>1600-0536</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10EtOwzAQBmALgWh5LLgAisQGFmk9fiTpEpWnVKkbWEeOO4aUJC52ItQdR-AsHIRDcBIMARZIeDOW_enX6CfkAOgIwhlruxgBn0i5QYaQUBpTyZNNMqRAZQxZygdkx_slpZAIlm2TAReciZTBkFzf3GPkbIWRNVHZtOgq7B7K5v35Bd5ew0vUBlDWddcEh35lG49RayNtm1bpNlJVhe4OG79HtoyqPO5_z11ye3F-M72KZ_PL6-npLNY8y2RsilSCLIxCAJUIQxcyA6F4uIVvbkQ60YkRRaEoIEhKjV4gThTXkBQ8M3yXHPe5K2cfO_RtXpdeY1WpBm3ncyZlytiEJizQoz90aTvXhO2CSjlnTDAR1EmvtLPeOzT5ypW1cuscaP7Zbx76zb_6DfbwO7Eralz8yp9CAxj34KmscP1_Uj6dn_WRH2VxhK0</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Yeung, Kelvin</creator><creator>Mraz, Veronika</creator><creator>Geisler, Carsten</creator><creator>Skov, Lone</creator><creator>Bonefeld, Charlotte M.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6083-3475</orcidid><orcidid>https://orcid.org/0000-0002-8472-0771</orcidid><orcidid>https://orcid.org/0000-0002-0523-6229</orcidid></search><sort><creationdate>202110</creationdate><title>The role of interleukin‐1β in the immune response to contact allergens</title><author>Yeung, Kelvin ; Mraz, Veronika ; Geisler, Carsten ; Skov, Lone ; Bonefeld, Charlotte M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3885-fb7515bfae11a64f0d5814a34f08853f479c6f4bba01e1500fcdee9a3c16b38f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Allergens</topic><topic>Allergens - immunology</topic><topic>allergic contact dermatitis</topic><topic>Animal models</topic><topic>Animals</topic><topic>Cell lineage</topic><topic>Contact dermatitis</topic><topic>Cytokines</topic><topic>Dermatitis, Allergic Contact - drug therapy</topic><topic>Dermatitis, Allergic Contact - immunology</topic><topic>Dermatitis, Atopic - drug therapy</topic><topic>Dermatitis, Atopic - immunology</topic><topic>Dermatitis, Irritant - drug therapy</topic><topic>Dermatitis, Irritant - immunology</topic><topic>Disease Models, Animal</topic><topic>Eczema</topic><topic>Humans</topic><topic>Immune response</topic><topic>immunology</topic><topic>Inflammation</topic><topic>Interleukin-1beta - antagonists & inhibitors</topic><topic>Interleukin-1beta - immunology</topic><topic>interleukin‐1β</topic><topic>Receptors, Interleukin-1 - antagonists & inhibitors</topic><topic>Receptors, Interleukin-1 - immunology</topic><topic>Signal Transduction</topic><topic>T cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yeung, Kelvin</creatorcontrib><creatorcontrib>Mraz, Veronika</creatorcontrib><creatorcontrib>Geisler, Carsten</creatorcontrib><creatorcontrib>Skov, Lone</creatorcontrib><creatorcontrib>Bonefeld, Charlotte M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Contact dermatitis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yeung, Kelvin</au><au>Mraz, Veronika</au><au>Geisler, Carsten</au><au>Skov, Lone</au><au>Bonefeld, Charlotte M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of interleukin‐1β in the immune response to contact allergens</atitle><jtitle>Contact dermatitis</jtitle><addtitle>Contact Dermatitis</addtitle><date>2021-10</date><risdate>2021</risdate><volume>85</volume><issue>4</issue><spage>387</spage><epage>397</epage><pages>387-397</pages><issn>0105-1873</issn><eissn>1600-0536</eissn><abstract>Interleukin‐1β (IL‐1β) is an important pro‐inflammatory cytokine that has an effect on almost every cell lineage in the body. By blocking IL‐1β and investigating the IL‐1β signaling pathway, several studies have demonstrated a central role of IL‐1β in the response to contact allergens. This review summarizes the current literature regarding the basic immunological mechanisms mediated by IL‐1β in the different phases of allergic contact dermatitis (ACD) and highlights potential IL‐1β‐targeted treatment options, which in the future may be relevant in the treatment of patients with ACD. This review is based primarily on studies using various mouse models and human in vitro studies, since clinical studies on the effect of IL‐1β in ACD are lacking.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>34324721</pmid><doi>10.1111/cod.13955</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-6083-3475</orcidid><orcidid>https://orcid.org/0000-0002-8472-0771</orcidid><orcidid>https://orcid.org/0000-0002-0523-6229</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0105-1873 |
| ispartof | Contact dermatitis, 2021-10, Vol.85 (4), p.387-397 |
| issn | 0105-1873 1600-0536 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2557229062 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Allergens Allergens - immunology allergic contact dermatitis Animal models Animals Cell lineage Contact dermatitis Cytokines Dermatitis, Allergic Contact - drug therapy Dermatitis, Allergic Contact - immunology Dermatitis, Atopic - drug therapy Dermatitis, Atopic - immunology Dermatitis, Irritant - drug therapy Dermatitis, Irritant - immunology Disease Models, Animal Eczema Humans Immune response immunology Inflammation Interleukin-1beta - antagonists & inhibitors Interleukin-1beta - immunology interleukin‐1β Receptors, Interleukin-1 - antagonists & inhibitors Receptors, Interleukin-1 - immunology Signal Transduction T cells |
| title | The role of interleukin‐1β in the immune response to contact allergens |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T03%3A18%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20interleukin%E2%80%901%CE%B2%20in%20the%20immune%20response%20to%20contact%20allergens&rft.jtitle=Contact%20dermatitis&rft.au=Yeung,%20Kelvin&rft.date=2021-10&rft.volume=85&rft.issue=4&rft.spage=387&rft.epage=397&rft.pages=387-397&rft.issn=0105-1873&rft.eissn=1600-0536&rft_id=info:doi/10.1111/cod.13955&rft_dat=%3Cproquest_cross%3E2573322424%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2573322424&rft_id=info:pmid/34324721&rfr_iscdi=true |