Characterization of a hyaluronic acid and folic acid-based hydrogel for cisplatin delivery: Antineoplastic effect in human ovarian cancer cells in vitro
[Display omitted] We successfully prepared and characterized a hyaluronic acid- and folic acid-based hydrogel for the delivery of cisplatin (GEL-CIS) with the aim to induce specific and efficient incorporation of CIS into ovarian cancer (OC) cells, improve its antineoplastic effect and avoid CIS-res...
Gespeichert in:
| Veröffentlicht in: | International journal of pharmaceutics 2021-09, Vol.606, p.120899-120899, Article 120899 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 120899 |
|---|---|
| container_issue | |
| container_start_page | 120899 |
| container_title | International journal of pharmaceutics |
| container_volume | 606 |
| creator | Serini, Simona Cassano, Roberta Bruni, Matilde Servidio, Camilla Calviello, Gabriella Trombino, Sonia |
| description | [Display omitted]
We successfully prepared and characterized a hyaluronic acid- and folic acid-based hydrogel for the delivery of cisplatin (GEL-CIS) with the aim to induce specific and efficient incorporation of CIS into ovarian cancer (OC) cells, improve its antineoplastic effect and avoid CIS-resistance. The slow and controlled release of the drug from the polymeric network and its swelling degree at physiologic pH suggested its suitability for CIS delivery in OC. We compared here the effects of pure CIS to that of GEL-CIS on human OC cell lines, either wild type or CIS-resistant, in basal conditions and in the presence of macrophage-derived conditioned medium, mimicking the action of tumor-associated macrophages in vivo. GEL-CIS inhibited OC cell growth and migration more efficiently than pure CIS and modulated the expression of proteins involved in the Epithelial Mesenchymal Transition, a process playing a key role in OC metastatic spread and resistance to CIS. |
| doi_str_mv | 10.1016/j.ijpharm.2021.120899 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2557228803</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378517321007055</els_id><sourcerecordid>2557228803</sourcerecordid><originalsourceid>FETCH-LOGICAL-c342t-a790e83074fc2dae1bdc24f409d8a36be1803ba5e4c46f56fa7cd453ee79838a3</originalsourceid><addsrcrecordid>eNqFUctu2zAQJIoEqPP4hAI89iKHD0mUeikMI20KGOilORNrchnTkEWXlA04X5LP7Rr2vafF7s7MPoaxL1LMpZDt03Yet_sN5N1cCSXnUomu7z-xmeyMrnRt2hs2E9p0VSON_szuStkKIVol9Yx9LIkIbsIc32GKaeQpcOCbEwyHnMboOLjoOYyehzRc02oNBT2BfE5vOFAncxfLfiCFkXsc4hHz6RtfjJRjonqZiIohoJs4QTaHHdCkI-RI0cHokBRwGMq5e4xTTg_sNsBQ8PEa79nrj-c_y5dq9fvnr-ViVTldq6kC0wvstDB1cMoDyrV3qg616H0Hul2j7IReQ4O1q9vQtAGM83WjEU3faYLcs68X3X1Ofw9YJruL5bwK0OaHYlXTGKU6UiFoc4G6nErJGOw-xx3kk5XCnp2wW3t1wp6dsBcniPf9wkO64xgx2-Ii0s0-ZnqI9Sn-R-EftgGYVA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2557228803</pqid></control><display><type>article</type><title>Characterization of a hyaluronic acid and folic acid-based hydrogel for cisplatin delivery: Antineoplastic effect in human ovarian cancer cells in vitro</title><source>Elsevier ScienceDirect Journals</source><creator>Serini, Simona ; Cassano, Roberta ; Bruni, Matilde ; Servidio, Camilla ; Calviello, Gabriella ; Trombino, Sonia</creator><creatorcontrib>Serini, Simona ; Cassano, Roberta ; Bruni, Matilde ; Servidio, Camilla ; Calviello, Gabriella ; Trombino, Sonia</creatorcontrib><description>[Display omitted]
We successfully prepared and characterized a hyaluronic acid- and folic acid-based hydrogel for the delivery of cisplatin (GEL-CIS) with the aim to induce specific and efficient incorporation of CIS into ovarian cancer (OC) cells, improve its antineoplastic effect and avoid CIS-resistance. The slow and controlled release of the drug from the polymeric network and its swelling degree at physiologic pH suggested its suitability for CIS delivery in OC. We compared here the effects of pure CIS to that of GEL-CIS on human OC cell lines, either wild type or CIS-resistant, in basal conditions and in the presence of macrophage-derived conditioned medium, mimicking the action of tumor-associated macrophages in vivo. GEL-CIS inhibited OC cell growth and migration more efficiently than pure CIS and modulated the expression of proteins involved in the Epithelial Mesenchymal Transition, a process playing a key role in OC metastatic spread and resistance to CIS.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2021.120899</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Carrier delivery ; Cisplatin ; Epithelial-Mesenchymal Transition ; Folic acid ; Hyaluronic acid ; Hydrogel ; Ovarian Cancer</subject><ispartof>International journal of pharmaceutics, 2021-09, Vol.606, p.120899-120899, Article 120899</ispartof><rights>2021 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-a790e83074fc2dae1bdc24f409d8a36be1803ba5e4c46f56fa7cd453ee79838a3</citedby><cites>FETCH-LOGICAL-c342t-a790e83074fc2dae1bdc24f409d8a36be1803ba5e4c46f56fa7cd453ee79838a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378517321007055$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids></links><search><creatorcontrib>Serini, Simona</creatorcontrib><creatorcontrib>Cassano, Roberta</creatorcontrib><creatorcontrib>Bruni, Matilde</creatorcontrib><creatorcontrib>Servidio, Camilla</creatorcontrib><creatorcontrib>Calviello, Gabriella</creatorcontrib><creatorcontrib>Trombino, Sonia</creatorcontrib><title>Characterization of a hyaluronic acid and folic acid-based hydrogel for cisplatin delivery: Antineoplastic effect in human ovarian cancer cells in vitro</title><title>International journal of pharmaceutics</title><description>[Display omitted]
We successfully prepared and characterized a hyaluronic acid- and folic acid-based hydrogel for the delivery of cisplatin (GEL-CIS) with the aim to induce specific and efficient incorporation of CIS into ovarian cancer (OC) cells, improve its antineoplastic effect and avoid CIS-resistance. The slow and controlled release of the drug from the polymeric network and its swelling degree at physiologic pH suggested its suitability for CIS delivery in OC. We compared here the effects of pure CIS to that of GEL-CIS on human OC cell lines, either wild type or CIS-resistant, in basal conditions and in the presence of macrophage-derived conditioned medium, mimicking the action of tumor-associated macrophages in vivo. GEL-CIS inhibited OC cell growth and migration more efficiently than pure CIS and modulated the expression of proteins involved in the Epithelial Mesenchymal Transition, a process playing a key role in OC metastatic spread and resistance to CIS.</description><subject>Carrier delivery</subject><subject>Cisplatin</subject><subject>Epithelial-Mesenchymal Transition</subject><subject>Folic acid</subject><subject>Hyaluronic acid</subject><subject>Hydrogel</subject><subject>Ovarian Cancer</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFUctu2zAQJIoEqPP4hAI89iKHD0mUeikMI20KGOilORNrchnTkEWXlA04X5LP7Rr2vafF7s7MPoaxL1LMpZDt03Yet_sN5N1cCSXnUomu7z-xmeyMrnRt2hs2E9p0VSON_szuStkKIVol9Yx9LIkIbsIc32GKaeQpcOCbEwyHnMboOLjoOYyehzRc02oNBT2BfE5vOFAncxfLfiCFkXsc4hHz6RtfjJRjonqZiIohoJs4QTaHHdCkI-RI0cHokBRwGMq5e4xTTg_sNsBQ8PEa79nrj-c_y5dq9fvnr-ViVTldq6kC0wvstDB1cMoDyrV3qg616H0Hul2j7IReQ4O1q9vQtAGM83WjEU3faYLcs68X3X1Ofw9YJruL5bwK0OaHYlXTGKU6UiFoc4G6nErJGOw-xx3kk5XCnp2wW3t1wp6dsBcniPf9wkO64xgx2-Ii0s0-ZnqI9Sn-R-EftgGYVA</recordid><startdate>20210905</startdate><enddate>20210905</enddate><creator>Serini, Simona</creator><creator>Cassano, Roberta</creator><creator>Bruni, Matilde</creator><creator>Servidio, Camilla</creator><creator>Calviello, Gabriella</creator><creator>Trombino, Sonia</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210905</creationdate><title>Characterization of a hyaluronic acid and folic acid-based hydrogel for cisplatin delivery: Antineoplastic effect in human ovarian cancer cells in vitro</title><author>Serini, Simona ; Cassano, Roberta ; Bruni, Matilde ; Servidio, Camilla ; Calviello, Gabriella ; Trombino, Sonia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-a790e83074fc2dae1bdc24f409d8a36be1803ba5e4c46f56fa7cd453ee79838a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Carrier delivery</topic><topic>Cisplatin</topic><topic>Epithelial-Mesenchymal Transition</topic><topic>Folic acid</topic><topic>Hyaluronic acid</topic><topic>Hydrogel</topic><topic>Ovarian Cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serini, Simona</creatorcontrib><creatorcontrib>Cassano, Roberta</creatorcontrib><creatorcontrib>Bruni, Matilde</creatorcontrib><creatorcontrib>Servidio, Camilla</creatorcontrib><creatorcontrib>Calviello, Gabriella</creatorcontrib><creatorcontrib>Trombino, Sonia</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serini, Simona</au><au>Cassano, Roberta</au><au>Bruni, Matilde</au><au>Servidio, Camilla</au><au>Calviello, Gabriella</au><au>Trombino, Sonia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of a hyaluronic acid and folic acid-based hydrogel for cisplatin delivery: Antineoplastic effect in human ovarian cancer cells in vitro</atitle><jtitle>International journal of pharmaceutics</jtitle><date>2021-09-05</date><risdate>2021</risdate><volume>606</volume><spage>120899</spage><epage>120899</epage><pages>120899-120899</pages><artnum>120899</artnum><issn>0378-5173</issn><eissn>1873-3476</eissn><abstract>[Display omitted]
We successfully prepared and characterized a hyaluronic acid- and folic acid-based hydrogel for the delivery of cisplatin (GEL-CIS) with the aim to induce specific and efficient incorporation of CIS into ovarian cancer (OC) cells, improve its antineoplastic effect and avoid CIS-resistance. The slow and controlled release of the drug from the polymeric network and its swelling degree at physiologic pH suggested its suitability for CIS delivery in OC. We compared here the effects of pure CIS to that of GEL-CIS on human OC cell lines, either wild type or CIS-resistant, in basal conditions and in the presence of macrophage-derived conditioned medium, mimicking the action of tumor-associated macrophages in vivo. GEL-CIS inhibited OC cell growth and migration more efficiently than pure CIS and modulated the expression of proteins involved in the Epithelial Mesenchymal Transition, a process playing a key role in OC metastatic spread and resistance to CIS.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.ijpharm.2021.120899</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 2021-09, Vol.606, p.120899-120899, Article 120899 |
| issn | 0378-5173 1873-3476 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2557228803 |
| source | Elsevier ScienceDirect Journals |
| subjects | Carrier delivery Cisplatin Epithelial-Mesenchymal Transition Folic acid Hyaluronic acid Hydrogel Ovarian Cancer |
| title | Characterization of a hyaluronic acid and folic acid-based hydrogel for cisplatin delivery: Antineoplastic effect in human ovarian cancer cells in vitro |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T05%3A55%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Characterization%20of%20a%20hyaluronic%20acid%20and%20folic%20acid-based%20hydrogel%20for%20cisplatin%20delivery:%20Antineoplastic%20effect%20in%20human%20ovarian%20cancer%20cells%20in%20vitro&rft.jtitle=International%20journal%20of%20pharmaceutics&rft.au=Serini,%20Simona&rft.date=2021-09-05&rft.volume=606&rft.spage=120899&rft.epage=120899&rft.pages=120899-120899&rft.artnum=120899&rft.issn=0378-5173&rft.eissn=1873-3476&rft_id=info:doi/10.1016/j.ijpharm.2021.120899&rft_dat=%3Cproquest_cross%3E2557228803%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2557228803&rft_id=info:pmid/&rft_els_id=S0378517321007055&rfr_iscdi=true |