Identification of different side effects between PARP inhibitors and their polypharmacological multi‐target rationale

Aims The aim of this study was to determine the differences and potential mechanistic rationale for observed adverse drug reactions (ADRs) between four approved PARP inhibitors (PARPi). Methods The Medicines and Healthcare products Regulatory Authority (MHRA) Yellow Card drug analysis profiles and N...

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Veröffentlicht in:	British journal of clinical pharmacology 2022-02, Vol.88 (2), p.742-752
Hauptverfasser:	Sandhu, Daranjit, Antolin, Albert A., Cox, Anthony R., Jones, Alan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	clinical pharmacology Drug-Related Side Effects and Adverse Reactions Humans oncology Poly(ADP-ribose) Polymerase Inhibitors - adverse effects Polypharmacology therapeutics
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