Association between thiamine decrease and neuropsychiatric symptoms in gastrointestinal and hematological cancer patients receiving chemotherapy
Clinical evidence of thiamine-related neuropsychiatric symptoms, including the initial stage, is limited because serum thiamine levels tend to be evaluated only for patients who develop severe neuropsychiatric symptoms suspected to be related to severe thiamine deficiency. This study aimed to evalua...
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| Veröffentlicht in: | Biomedicine & pharmacotherapy 2021-09, Vol.141, p.111929-111929, Article 111929 |
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| creator | Iimura, Yohei Kurokawa, Tomohiro Andoh, Shohei Kanemoto, Yoshiaki Kawamata, Toyotaka Yazawa, Kentaro Sato, Aki Yokoyama, Kazuaki Imai, Yoichi Tsurita, Giichiro Ahiko, Yuka Aikou, Susumu Shida, Dai Nojima, Masanori Tojo, Arinobu Sugiura, Munetoshi Kuroda, Seiichiro |
| description | Clinical evidence of thiamine-related neuropsychiatric symptoms, including the initial stage, is limited because serum thiamine levels tend to be evaluated only for patients who develop severe neuropsychiatric symptoms suspected to be related to severe thiamine deficiency. This study aimed to evaluate the relationship between thiamine decline and neuropsychiatric symptoms, including initial symptoms, and the effect of chemotherapy on serum thiamine levels in gastrointestinal and hematological cancer patients receiving chemotherapy.
We retrospectively identified 87 patients who were diagnosed with gastrointestinal and hematological cancers at our hospital. We evaluated the risk factors associated with neuropsychiatric symptoms, including initial symptoms (neuropsychiatric symptoms), the relationship between the presence of neuropsychiatric symptoms and serum thiamine levels, and changes in serum thiamine levels after chemotherapy.
Logistic regression analysis identified thiamine decline as a significant factor associated with neuropsychiatric symptoms (p |
| doi_str_mv | 10.1016/j.biopha.2021.111929 |
| format | Article |
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We retrospectively identified 87 patients who were diagnosed with gastrointestinal and hematological cancers at our hospital. We evaluated the risk factors associated with neuropsychiatric symptoms, including initial symptoms (neuropsychiatric symptoms), the relationship between the presence of neuropsychiatric symptoms and serum thiamine levels, and changes in serum thiamine levels after chemotherapy.
Logistic regression analysis identified thiamine decline as a significant factor associated with neuropsychiatric symptoms (p < 0.001, odds ratio = 0.040, 95% confidence interval [CI]: 0.010–0.163). The Mann-Whitney U test showed that patients with neuropsychiatric symptoms had significantly lower serum thiamine levels (19.5 ± 5.4 ng/mL, n = 39) than patients without neuropsychiatric symptoms (31.9 ± 14.2 ng/mL, n = 48) (p = 0.001). In hematological cancer patients, serum thiamine levels gradually declined after chemotherapy, with the lowest levels at 5–8 weeks (23.5 ± 7.6 ng/mL, P = 0.035 vs. 0 weeks, Wilcoxon rank sum test).
Our study showed that a decrease in serum thiamine levels can be a risk factor for neuropsychiatric symptoms, and chemotherapy can lead to a decrease in serum thiamine levels.
•Thiamine decline was associated with neuropsychiatric symptoms.•Chemotherapy can lower serum thiamine levels in cancer patients.•Low dose thiamine may improve thiamine related neuropsychiatric symptoms.</description><identifier>ISSN: 0753-3322</identifier><identifier>EISSN: 1950-6007</identifier><identifier>DOI: 10.1016/j.biopha.2021.111929</identifier><identifier>PMID: 34328118</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents - adverse effects ; Biomarkers - blood ; Cancer ; Chemotherapy ; Female ; Gastrointestinal ; Gastrointestinal Neoplasms - blood ; Gastrointestinal Neoplasms - drug therapy ; Gastrointestinal Neoplasms - epidemiology ; Hematologic Neoplasms - blood ; Hematologic Neoplasms - drug therapy ; Hematologic Neoplasms - epidemiology ; Hematological ; Humans ; Male ; Mental Disorders - blood ; Mental Disorders - epidemiology ; Middle Aged ; Neuropsychiatric symptoms ; Retrospective Studies ; Thiamine ; Thiamine - blood ; Thiamine Deficiency - blood ; Thiamine Deficiency - epidemiology ; Young Adult</subject><ispartof>Biomedicine & pharmacotherapy, 2021-09, Vol.141, p.111929-111929, Article 111929</ispartof><rights>2021 The Authors</rights><rights>Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-16d8ca547830be18efee358f7b411b1736602182514659c6d0b69f03118b9b3</citedby><cites>FETCH-LOGICAL-c474t-16d8ca547830be18efee358f7b411b1736602182514659c6d0b69f03118b9b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0753332221007113$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34328118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iimura, Yohei</creatorcontrib><creatorcontrib>Kurokawa, Tomohiro</creatorcontrib><creatorcontrib>Andoh, Shohei</creatorcontrib><creatorcontrib>Kanemoto, Yoshiaki</creatorcontrib><creatorcontrib>Kawamata, Toyotaka</creatorcontrib><creatorcontrib>Yazawa, Kentaro</creatorcontrib><creatorcontrib>Sato, Aki</creatorcontrib><creatorcontrib>Yokoyama, Kazuaki</creatorcontrib><creatorcontrib>Imai, Yoichi</creatorcontrib><creatorcontrib>Tsurita, Giichiro</creatorcontrib><creatorcontrib>Ahiko, Yuka</creatorcontrib><creatorcontrib>Aikou, Susumu</creatorcontrib><creatorcontrib>Shida, Dai</creatorcontrib><creatorcontrib>Nojima, Masanori</creatorcontrib><creatorcontrib>Tojo, Arinobu</creatorcontrib><creatorcontrib>Sugiura, Munetoshi</creatorcontrib><creatorcontrib>Kuroda, Seiichiro</creatorcontrib><title>Association between thiamine decrease and neuropsychiatric symptoms in gastrointestinal and hematological cancer patients receiving chemotherapy</title><title>Biomedicine & pharmacotherapy</title><addtitle>Biomed Pharmacother</addtitle><description>Clinical evidence of thiamine-related neuropsychiatric symptoms, including the initial stage, is limited because serum thiamine levels tend to be evaluated only for patients who develop severe neuropsychiatric symptoms suspected to be related to severe thiamine deficiency. This study aimed to evaluate the relationship between thiamine decline and neuropsychiatric symptoms, including initial symptoms, and the effect of chemotherapy on serum thiamine levels in gastrointestinal and hematological cancer patients receiving chemotherapy.
We retrospectively identified 87 patients who were diagnosed with gastrointestinal and hematological cancers at our hospital. We evaluated the risk factors associated with neuropsychiatric symptoms, including initial symptoms (neuropsychiatric symptoms), the relationship between the presence of neuropsychiatric symptoms and serum thiamine levels, and changes in serum thiamine levels after chemotherapy.
Logistic regression analysis identified thiamine decline as a significant factor associated with neuropsychiatric symptoms (p < 0.001, odds ratio = 0.040, 95% confidence interval [CI]: 0.010–0.163). The Mann-Whitney U test showed that patients with neuropsychiatric symptoms had significantly lower serum thiamine levels (19.5 ± 5.4 ng/mL, n = 39) than patients without neuropsychiatric symptoms (31.9 ± 14.2 ng/mL, n = 48) (p = 0.001). In hematological cancer patients, serum thiamine levels gradually declined after chemotherapy, with the lowest levels at 5–8 weeks (23.5 ± 7.6 ng/mL, P = 0.035 vs. 0 weeks, Wilcoxon rank sum test).
Our study showed that a decrease in serum thiamine levels can be a risk factor for neuropsychiatric symptoms, and chemotherapy can lead to a decrease in serum thiamine levels.
•Thiamine decline was associated with neuropsychiatric symptoms.•Chemotherapy can lower serum thiamine levels in cancer patients.•Low dose thiamine may improve thiamine related neuropsychiatric symptoms.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Biomarkers - blood</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Female</subject><subject>Gastrointestinal</subject><subject>Gastrointestinal Neoplasms - blood</subject><subject>Gastrointestinal Neoplasms - drug therapy</subject><subject>Gastrointestinal Neoplasms - epidemiology</subject><subject>Hematologic Neoplasms - blood</subject><subject>Hematologic Neoplasms - drug therapy</subject><subject>Hematologic Neoplasms - epidemiology</subject><subject>Hematological</subject><subject>Humans</subject><subject>Male</subject><subject>Mental Disorders - blood</subject><subject>Mental Disorders - epidemiology</subject><subject>Middle Aged</subject><subject>Neuropsychiatric symptoms</subject><subject>Retrospective Studies</subject><subject>Thiamine</subject><subject>Thiamine - blood</subject><subject>Thiamine Deficiency - blood</subject><subject>Thiamine Deficiency - epidemiology</subject><subject>Young Adult</subject><issn>0753-3322</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2O1DAQhC0EYoeFN0DIRy4Z_BM7yQVpteJPWokD3C3b6cx4lNjB7Vk0b8Ej4yULR06W7K9c3VWEvOZszxnX7057F9J6tHvBBN9zzgcxPCE7PijWaMa6p2THOiUbKYW4Ii8QT4wxpWX_nFzJVoqe835Hft0gJh9sCSlSB-UnQKTlGOwSItARfAaLQG0caYRzTitefH0tOXiKl2UtaUEaIj1YLDmFWABLiHb-ozjCYkua0yH4euNt9JDpWr0gFqQZPIT7EA_UVzCVI2S7Xl6SZ5OdEV49ntfk28cP328_N3dfP325vblrfNu1peF67L1VbddL5oD3MAFI1U-dazl3vJNa11h6oXir1eD1yJweJibr0m5w8pq83X5dc_pxrjObJaCHebYR0hmNUKoTomsHUdF2Q31OiBkms-aw2HwxnJmHJszJbE2YhybM1kSVvXl0OLsFxn-iv9FX4P0GQN3yPkA26GswHsZQkylmTOH_Dr8B7IufhA</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Iimura, Yohei</creator><creator>Kurokawa, Tomohiro</creator><creator>Andoh, Shohei</creator><creator>Kanemoto, Yoshiaki</creator><creator>Kawamata, Toyotaka</creator><creator>Yazawa, Kentaro</creator><creator>Sato, Aki</creator><creator>Yokoyama, Kazuaki</creator><creator>Imai, Yoichi</creator><creator>Tsurita, Giichiro</creator><creator>Ahiko, Yuka</creator><creator>Aikou, Susumu</creator><creator>Shida, Dai</creator><creator>Nojima, Masanori</creator><creator>Tojo, Arinobu</creator><creator>Sugiura, Munetoshi</creator><creator>Kuroda, Seiichiro</creator><general>Elsevier Masson SAS</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202109</creationdate><title>Association between thiamine decrease and neuropsychiatric symptoms in gastrointestinal and hematological cancer patients receiving chemotherapy</title><author>Iimura, Yohei ; Kurokawa, Tomohiro ; Andoh, Shohei ; Kanemoto, Yoshiaki ; Kawamata, Toyotaka ; Yazawa, Kentaro ; Sato, Aki ; Yokoyama, Kazuaki ; Imai, Yoichi ; Tsurita, Giichiro ; Ahiko, Yuka ; Aikou, Susumu ; Shida, Dai ; Nojima, Masanori ; Tojo, Arinobu ; Sugiura, Munetoshi ; Kuroda, Seiichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-16d8ca547830be18efee358f7b411b1736602182514659c6d0b69f03118b9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Biomarkers - blood</topic><topic>Cancer</topic><topic>Chemotherapy</topic><topic>Female</topic><topic>Gastrointestinal</topic><topic>Gastrointestinal Neoplasms - blood</topic><topic>Gastrointestinal Neoplasms - drug therapy</topic><topic>Gastrointestinal Neoplasms - epidemiology</topic><topic>Hematologic Neoplasms - blood</topic><topic>Hematologic Neoplasms - drug therapy</topic><topic>Hematologic Neoplasms - epidemiology</topic><topic>Hematological</topic><topic>Humans</topic><topic>Male</topic><topic>Mental Disorders - blood</topic><topic>Mental Disorders - epidemiology</topic><topic>Middle Aged</topic><topic>Neuropsychiatric symptoms</topic><topic>Retrospective Studies</topic><topic>Thiamine</topic><topic>Thiamine - blood</topic><topic>Thiamine Deficiency - blood</topic><topic>Thiamine Deficiency - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iimura, Yohei</creatorcontrib><creatorcontrib>Kurokawa, Tomohiro</creatorcontrib><creatorcontrib>Andoh, Shohei</creatorcontrib><creatorcontrib>Kanemoto, Yoshiaki</creatorcontrib><creatorcontrib>Kawamata, Toyotaka</creatorcontrib><creatorcontrib>Yazawa, Kentaro</creatorcontrib><creatorcontrib>Sato, Aki</creatorcontrib><creatorcontrib>Yokoyama, Kazuaki</creatorcontrib><creatorcontrib>Imai, Yoichi</creatorcontrib><creatorcontrib>Tsurita, Giichiro</creatorcontrib><creatorcontrib>Ahiko, Yuka</creatorcontrib><creatorcontrib>Aikou, Susumu</creatorcontrib><creatorcontrib>Shida, Dai</creatorcontrib><creatorcontrib>Nojima, Masanori</creatorcontrib><creatorcontrib>Tojo, Arinobu</creatorcontrib><creatorcontrib>Sugiura, Munetoshi</creatorcontrib><creatorcontrib>Kuroda, Seiichiro</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedicine & pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iimura, Yohei</au><au>Kurokawa, Tomohiro</au><au>Andoh, Shohei</au><au>Kanemoto, Yoshiaki</au><au>Kawamata, Toyotaka</au><au>Yazawa, Kentaro</au><au>Sato, Aki</au><au>Yokoyama, Kazuaki</au><au>Imai, Yoichi</au><au>Tsurita, Giichiro</au><au>Ahiko, Yuka</au><au>Aikou, Susumu</au><au>Shida, Dai</au><au>Nojima, Masanori</au><au>Tojo, Arinobu</au><au>Sugiura, Munetoshi</au><au>Kuroda, Seiichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between thiamine decrease and neuropsychiatric symptoms in gastrointestinal and hematological cancer patients receiving chemotherapy</atitle><jtitle>Biomedicine & pharmacotherapy</jtitle><addtitle>Biomed Pharmacother</addtitle><date>2021-09</date><risdate>2021</risdate><volume>141</volume><spage>111929</spage><epage>111929</epage><pages>111929-111929</pages><artnum>111929</artnum><issn>0753-3322</issn><eissn>1950-6007</eissn><abstract>Clinical evidence of thiamine-related neuropsychiatric symptoms, including the initial stage, is limited because serum thiamine levels tend to be evaluated only for patients who develop severe neuropsychiatric symptoms suspected to be related to severe thiamine deficiency. This study aimed to evaluate the relationship between thiamine decline and neuropsychiatric symptoms, including initial symptoms, and the effect of chemotherapy on serum thiamine levels in gastrointestinal and hematological cancer patients receiving chemotherapy.
We retrospectively identified 87 patients who were diagnosed with gastrointestinal and hematological cancers at our hospital. We evaluated the risk factors associated with neuropsychiatric symptoms, including initial symptoms (neuropsychiatric symptoms), the relationship between the presence of neuropsychiatric symptoms and serum thiamine levels, and changes in serum thiamine levels after chemotherapy.
Logistic regression analysis identified thiamine decline as a significant factor associated with neuropsychiatric symptoms (p < 0.001, odds ratio = 0.040, 95% confidence interval [CI]: 0.010–0.163). The Mann-Whitney U test showed that patients with neuropsychiatric symptoms had significantly lower serum thiamine levels (19.5 ± 5.4 ng/mL, n = 39) than patients without neuropsychiatric symptoms (31.9 ± 14.2 ng/mL, n = 48) (p = 0.001). In hematological cancer patients, serum thiamine levels gradually declined after chemotherapy, with the lowest levels at 5–8 weeks (23.5 ± 7.6 ng/mL, P = 0.035 vs. 0 weeks, Wilcoxon rank sum test).
Our study showed that a decrease in serum thiamine levels can be a risk factor for neuropsychiatric symptoms, and chemotherapy can lead to a decrease in serum thiamine levels.
•Thiamine decline was associated with neuropsychiatric symptoms.•Chemotherapy can lower serum thiamine levels in cancer patients.•Low dose thiamine may improve thiamine related neuropsychiatric symptoms.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>34328118</pmid><doi>10.1016/j.biopha.2021.111929</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Antineoplastic Agents - adverse effects Biomarkers - blood Cancer Chemotherapy Female Gastrointestinal Gastrointestinal Neoplasms - blood Gastrointestinal Neoplasms - drug therapy Gastrointestinal Neoplasms - epidemiology Hematologic Neoplasms - blood Hematologic Neoplasms - drug therapy Hematologic Neoplasms - epidemiology Hematological Humans Male Mental Disorders - blood Mental Disorders - epidemiology Middle Aged Neuropsychiatric symptoms Retrospective Studies Thiamine Thiamine - blood Thiamine Deficiency - blood Thiamine Deficiency - epidemiology Young Adult |
| title | Association between thiamine decrease and neuropsychiatric symptoms in gastrointestinal and hematological cancer patients receiving chemotherapy |
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