One‐Step Synthesis of Photoaffinity Probes for Live‐Cell MS‐Based Proteomics

We present a one‐step Ugi reaction protocol for the expedient synthesis of photoaffinity probes for live‐cell MS‐based proteomics. The reaction couples an amine affinity function with commonly used photoreactive groups, and a variety of handle functionalities. Using this technology, a series of pan‐...

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Veröffentlicht in:	Chemistry : a European journal 2021-12, Vol.27 (71), p.17880-17888
Hauptverfasser:	Fallon, David J., Lehmann, Stephanie, Chung, Chun‐wa, Phillipou, Alex, Eberl, Christian, Fantom, Ken G. M., Zappacosta, Francesca, Patel, Vipulkumar K., Bantscheff, Marcus, Schofield, Christopher J., Tomkinson, Nicholas C. O., Bush, Jacob T.
Format:	Artikel
Sprache:	eng
Schlagworte:	bromodomains epigenetics MS-based proteomics multi-component reactions photoaffinity labelling Proteomics
Online-Zugang:	Volltext
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