Synthesis of a novel glibenclamide-pioglitazone hybrid compound and its effects on glucose homeostasis in normal and insulin-resistant rats

[Display omitted] •A new library of hybrid molecules was assayed as antihyperglycemic compounds.•In vivo and in vitro studies selected PTEBS as a novel insulin secretagogue compound.•PTEBS increased the glycogen accumulation and stimulated GLUT4 translocation.•PTEBS was effective in increasing insul...

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