Sterically Bulky Caging of Transferrin for Photoactivatable Intracellular Delivery

Photoactivatable ligand proteins are potentially useful for light-induced intracellular delivery of therapeutic and diagnostic cargos through receptor-mediated cellular uptake. Here, we report the simple and effective caging of transferrin (Tf), a representative ligand protein with cellular uptake a...

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Veröffentlicht in:	Bioconjugate chemistry 2021-08, Vol.32 (8), p.1535-1540
Hauptverfasser:	Yamaguchi, Satoshi, Takamori, Satoshi, Yamamoto, Kazuho, Ishiwatari, Akira, Minamihata, Kosuke, Yamada, Eriko, Okamoto, Akimitsu, Nagamune, Teruyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - pharmacokinetics Biotin Biotin-binding protein Biotinylation Cell Line, Tumor Cell viability Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - chemistry Delayed-Action Preparations - pharmacokinetics Doxorubicin Doxorubicin - administration & dosage Doxorubicin - chemistry Doxorubicin - pharmacokinetics Exposure Humans Intracellular Ligands Light Models, Molecular Neoplasms - drug therapy Proteins Receptors Steric hindrance Streptavidin Transferrin Transferrin - administration & dosage Transferrin - chemistry Transferrin - pharmacokinetics
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