The distribution of common-variant effect sizes

The genetic effect-size distribution of a disease describes the number of risk variants, the range of their effect sizes and sample sizes that will be required to discover them. Accurate estimation has been a challenge. Here I propose Fourier Mixture Regression (FMR), validating that it accurately e...

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Veröffentlicht in:	Nature genetics 2021-08, Vol.53 (8), p.1243-1249
1. Verfasser:	O’Connor, Luke J.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/205 631/208/205/2138 Agriculture Animal Genetics and Genomics Biobanks Biomedical and Life Sciences Biomedicine Cancer Research Estimates Gene Function Genetic research Genetic variation Genomes Heritability Human Genetics Methods Mixture models Regression analysis Simulation Single-nucleotide polymorphism Size distribution
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