Comparative study of spermatogonial survival after X-ray exposure, high let (HZE) irradiation or spaceflight
Spermatogonial cell loss has been observed in rats flown on Space Lab 3, Cosmos 1887, Cosmos 2044 and in mice following irradiation with X-ray or with high energy (HZE) particle beams. Spermatogonial loss is determined by cell counting in maturation stage 6 seminferous tubules. With the exception of...
Gespeichert in:
| Veröffentlicht in: | Advances in space research 1992, Vol.12 (2), p.179-189 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 189 |
|---|---|
| container_issue | 2 |
| container_start_page | 179 |
| container_title | Advances in space research |
| container_volume | 12 |
| creator | Sapp, W.J. Philpott, D.E. Williams, C.S. Williams, J.W. Kato, K. Miquel, J.M. Serova, L. |
| description | Spermatogonial cell loss has been observed in rats flown on Space Lab 3, Cosmos 1887, Cosmos 2044 and in mice following irradiation with X-ray or with high energy (HZE) particle beams. Spermatogonial loss is determined by cell counting in maturation stage 6 seminferous tubules. With the exception of Iron, laboratory irradiation experiments (with mice) revealed a similar pattern of spermatogonial loss proportional to the radiation dose at levels less than 0.1 Gy. Helium and Argon irradiation resulted in a 5% loss of spermatogonia after only 0.01 Gy exposure. However, significant spermatogonial loss (45%) occurred at this radiation level with Iron particle beams. The loss of spermatogonia during each space flight was less than 10% when compared to control (non-flight) animals. This loss, although small, was significant. Although radiation may be a contributing factor in the loss of spermatogonia during space flight, exposure levels, as determined by dosimetry, were not significant to account for the total cell loss observed. |
| doi_str_mv | 10.1016/0273-1177(92)90106-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_25566082</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0273117792901068</els_id><sourcerecordid>25566082</sourcerecordid><originalsourceid>FETCH-LOGICAL-c455t-7c3cdb839c068e235d765775be5e90ac76881a74f89e080c82439d06fbf8dc553</originalsourceid><addsrcrecordid>eNp9kE1r3DAQhkVpSTZp_kEpOpUE4nZkW5Z0CYQlH4VALy2UXoRWGicq9sqV5CX776PtLs2tpxmYZ95hHkI-MPjMgHVfoBZNxZgQ56q-UMCgq-QbsmBSqIqpVr4li3_IMTlJ6TcAq4WAI3LMGG8EgFiQYRnGyUST_QZpyrPb0tDTNGEcTQ6PYe3NQNMcN35TGtNnjPRnFc2W4vMUygAv6ZN_fKIDZnp-_-vmgvoYjfMlMaxpiCXLWOyHwuT35F1vhoRnh3pKftzefF_eVw_f7r4urx8q23KeK2Eb61ayURY6iXXDnei4EHyFHBUYKzopmRFtLxWCBCvrtlEOun7VS2c5b07Jp33uFMOfGVPWo08Wh8GsMcxJ15x3Hci6gO0etDGkFLHXU_SjiVvNQO8s651CvVOoVa3_WtayrH085M-rEd3r0kFrAa72AJYvNx6jTtbj2qLzEW3WLvj_X3gBVZ2Mhw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>25566082</pqid></control><display><type>article</type><title>Comparative study of spermatogonial survival after X-ray exposure, high let (HZE) irradiation or spaceflight</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Sapp, W.J. ; Philpott, D.E. ; Williams, C.S. ; Williams, J.W. ; Kato, K. ; Miquel, J.M. ; Serova, L.</creator><creatorcontrib>Sapp, W.J. ; Philpott, D.E. ; Williams, C.S. ; Williams, J.W. ; Kato, K. ; Miquel, J.M. ; Serova, L.</creatorcontrib><description>Spermatogonial cell loss has been observed in rats flown on Space Lab 3, Cosmos 1887, Cosmos 2044 and in mice following irradiation with X-ray or with high energy (HZE) particle beams. Spermatogonial loss is determined by cell counting in maturation stage 6 seminferous tubules. With the exception of Iron, laboratory irradiation experiments (with mice) revealed a similar pattern of spermatogonial loss proportional to the radiation dose at levels less than 0.1 Gy. Helium and Argon irradiation resulted in a 5% loss of spermatogonia after only 0.01 Gy exposure. However, significant spermatogonial loss (45%) occurred at this radiation level with Iron particle beams. The loss of spermatogonia during each space flight was less than 10% when compared to control (non-flight) animals. This loss, although small, was significant. Although radiation may be a contributing factor in the loss of spermatogonia during space flight, exposure levels, as determined by dosimetry, were not significant to account for the total cell loss observed.</description><identifier>ISSN: 0273-1177</identifier><identifier>EISSN: 1879-1948</identifier><identifier>DOI: 10.1016/0273-1177(92)90106-8</identifier><identifier>PMID: 11537007</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Cell Survival ; Cosmic Radiation - adverse effects ; Iron - adverse effects ; Linear Energy Transfer ; Male ; Mice ; Noble Gases - adverse effects ; Rats ; Seminiferous Tubules - radiation effects ; Seminiferous Tubules - ultrastructure ; Sertoli Cells - cytology ; Sertoli Cells - radiation effects ; Space Flight ; Spermatocytes - cytology ; Spermatocytes - radiation effects ; Spermatogonia - pathology ; Spermatogonia - radiation effects ; Weightlessness</subject><ispartof>Advances in space research, 1992, Vol.12 (2), p.179-189</ispartof><rights>1991</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-7c3cdb839c068e235d765775be5e90ac76881a74f89e080c82439d06fbf8dc553</citedby><cites>FETCH-LOGICAL-c455t-7c3cdb839c068e235d765775be5e90ac76881a74f89e080c82439d06fbf8dc553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0273-1177(92)90106-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11537007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sapp, W.J.</creatorcontrib><creatorcontrib>Philpott, D.E.</creatorcontrib><creatorcontrib>Williams, C.S.</creatorcontrib><creatorcontrib>Williams, J.W.</creatorcontrib><creatorcontrib>Kato, K.</creatorcontrib><creatorcontrib>Miquel, J.M.</creatorcontrib><creatorcontrib>Serova, L.</creatorcontrib><title>Comparative study of spermatogonial survival after X-ray exposure, high let (HZE) irradiation or spaceflight</title><title>Advances in space research</title><addtitle>Adv Space Res</addtitle><description>Spermatogonial cell loss has been observed in rats flown on Space Lab 3, Cosmos 1887, Cosmos 2044 and in mice following irradiation with X-ray or with high energy (HZE) particle beams. Spermatogonial loss is determined by cell counting in maturation stage 6 seminferous tubules. With the exception of Iron, laboratory irradiation experiments (with mice) revealed a similar pattern of spermatogonial loss proportional to the radiation dose at levels less than 0.1 Gy. Helium and Argon irradiation resulted in a 5% loss of spermatogonia after only 0.01 Gy exposure. However, significant spermatogonial loss (45%) occurred at this radiation level with Iron particle beams. The loss of spermatogonia during each space flight was less than 10% when compared to control (non-flight) animals. This loss, although small, was significant. Although radiation may be a contributing factor in the loss of spermatogonia during space flight, exposure levels, as determined by dosimetry, were not significant to account for the total cell loss observed.</description><subject>Animals</subject><subject>Cell Survival</subject><subject>Cosmic Radiation - adverse effects</subject><subject>Iron - adverse effects</subject><subject>Linear Energy Transfer</subject><subject>Male</subject><subject>Mice</subject><subject>Noble Gases - adverse effects</subject><subject>Rats</subject><subject>Seminiferous Tubules - radiation effects</subject><subject>Seminiferous Tubules - ultrastructure</subject><subject>Sertoli Cells - cytology</subject><subject>Sertoli Cells - radiation effects</subject><subject>Space Flight</subject><subject>Spermatocytes - cytology</subject><subject>Spermatocytes - radiation effects</subject><subject>Spermatogonia - pathology</subject><subject>Spermatogonia - radiation effects</subject><subject>Weightlessness</subject><issn>0273-1177</issn><issn>1879-1948</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpSTZp_kEpOpUE4nZkW5Z0CYQlH4VALy2UXoRWGicq9sqV5CX776PtLs2tpxmYZ95hHkI-MPjMgHVfoBZNxZgQ56q-UMCgq-QbsmBSqIqpVr4li3_IMTlJ6TcAq4WAI3LMGG8EgFiQYRnGyUST_QZpyrPb0tDTNGEcTQ6PYe3NQNMcN35TGtNnjPRnFc2W4vMUygAv6ZN_fKIDZnp-_-vmgvoYjfMlMaxpiCXLWOyHwuT35F1vhoRnh3pKftzefF_eVw_f7r4urx8q23KeK2Eb61ayURY6iXXDnei4EHyFHBUYKzopmRFtLxWCBCvrtlEOun7VS2c5b07Jp33uFMOfGVPWo08Wh8GsMcxJ15x3Hci6gO0etDGkFLHXU_SjiVvNQO8s651CvVOoVa3_WtayrH085M-rEd3r0kFrAa72AJYvNx6jTtbj2qLzEW3WLvj_X3gBVZ2Mhw</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Sapp, W.J.</creator><creator>Philpott, D.E.</creator><creator>Williams, C.S.</creator><creator>Williams, J.W.</creator><creator>Kato, K.</creator><creator>Miquel, J.M.</creator><creator>Serova, L.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope></search><sort><creationdate>1992</creationdate><title>Comparative study of spermatogonial survival after X-ray exposure, high let (HZE) irradiation or spaceflight</title><author>Sapp, W.J. ; Philpott, D.E. ; Williams, C.S. ; Williams, J.W. ; Kato, K. ; Miquel, J.M. ; Serova, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-7c3cdb839c068e235d765775be5e90ac76881a74f89e080c82439d06fbf8dc553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Cell Survival</topic><topic>Cosmic Radiation - adverse effects</topic><topic>Iron - adverse effects</topic><topic>Linear Energy Transfer</topic><topic>Male</topic><topic>Mice</topic><topic>Noble Gases - adverse effects</topic><topic>Rats</topic><topic>Seminiferous Tubules - radiation effects</topic><topic>Seminiferous Tubules - ultrastructure</topic><topic>Sertoli Cells - cytology</topic><topic>Sertoli Cells - radiation effects</topic><topic>Space Flight</topic><topic>Spermatocytes - cytology</topic><topic>Spermatocytes - radiation effects</topic><topic>Spermatogonia - pathology</topic><topic>Spermatogonia - radiation effects</topic><topic>Weightlessness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sapp, W.J.</creatorcontrib><creatorcontrib>Philpott, D.E.</creatorcontrib><creatorcontrib>Williams, C.S.</creatorcontrib><creatorcontrib>Williams, J.W.</creatorcontrib><creatorcontrib>Kato, K.</creatorcontrib><creatorcontrib>Miquel, J.M.</creatorcontrib><creatorcontrib>Serova, L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Advances in space research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sapp, W.J.</au><au>Philpott, D.E.</au><au>Williams, C.S.</au><au>Williams, J.W.</au><au>Kato, K.</au><au>Miquel, J.M.</au><au>Serova, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative study of spermatogonial survival after X-ray exposure, high let (HZE) irradiation or spaceflight</atitle><jtitle>Advances in space research</jtitle><addtitle>Adv Space Res</addtitle><date>1992</date><risdate>1992</risdate><volume>12</volume><issue>2</issue><spage>179</spage><epage>189</epage><pages>179-189</pages><issn>0273-1177</issn><eissn>1879-1948</eissn><abstract>Spermatogonial cell loss has been observed in rats flown on Space Lab 3, Cosmos 1887, Cosmos 2044 and in mice following irradiation with X-ray or with high energy (HZE) particle beams. Spermatogonial loss is determined by cell counting in maturation stage 6 seminferous tubules. With the exception of Iron, laboratory irradiation experiments (with mice) revealed a similar pattern of spermatogonial loss proportional to the radiation dose at levels less than 0.1 Gy. Helium and Argon irradiation resulted in a 5% loss of spermatogonia after only 0.01 Gy exposure. However, significant spermatogonial loss (45%) occurred at this radiation level with Iron particle beams. The loss of spermatogonia during each space flight was less than 10% when compared to control (non-flight) animals. This loss, although small, was significant. Although radiation may be a contributing factor in the loss of spermatogonia during space flight, exposure levels, as determined by dosimetry, were not significant to account for the total cell loss observed.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>11537007</pmid><doi>10.1016/0273-1177(92)90106-8</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0273-1177 |
| ispartof | Advances in space research, 1992, Vol.12 (2), p.179-189 |
| issn | 0273-1177 1879-1948 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_25566082 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Cell Survival Cosmic Radiation - adverse effects Iron - adverse effects Linear Energy Transfer Male Mice Noble Gases - adverse effects Rats Seminiferous Tubules - radiation effects Seminiferous Tubules - ultrastructure Sertoli Cells - cytology Sertoli Cells - radiation effects Space Flight Spermatocytes - cytology Spermatocytes - radiation effects Spermatogonia - pathology Spermatogonia - radiation effects Weightlessness |
| title | Comparative study of spermatogonial survival after X-ray exposure, high let (HZE) irradiation or spaceflight |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T08%3A10%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparative%20study%20of%20spermatogonial%20survival%20after%20X-ray%20exposure,%20high%20let%20(HZE)%20irradiation%20or%20spaceflight&rft.jtitle=Advances%20in%20space%20research&rft.au=Sapp,%20W.J.&rft.date=1992&rft.volume=12&rft.issue=2&rft.spage=179&rft.epage=189&rft.pages=179-189&rft.issn=0273-1177&rft.eissn=1879-1948&rft_id=info:doi/10.1016/0273-1177(92)90106-8&rft_dat=%3Cproquest_cross%3E25566082%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=25566082&rft_id=info:pmid/11537007&rft_els_id=0273117792901068&rfr_iscdi=true |