New antimicrobial self-assembling short lipopeptides
Lipopeptides are an exceptional example of amphiphilic molecules that self-assemble into functional structures with applications in the areas of nanotechnology, catalysis or medicinal chemistry. Herein, we report a library of 21 short lipopeptides, together with their supramolecular characterization...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2021-08, Vol.19 (31), p.6797-683 |
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| container_title | Organic & biomolecular chemistry |
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| creator | Vicente-García, César Colomer, Ignacio |
| description | Lipopeptides are an exceptional example of amphiphilic molecules that self-assemble into functional structures with applications in the areas of nanotechnology, catalysis or medicinal chemistry. Herein, we report a library of 21 short lipopeptides, together with their supramolecular characterization and antimicrobial activity against both Gram-negative (
E. coli
) and Gram-positive (
S. aureus
) strains. This study shows that simple lipoamino acids self-assemble into micellar or vesicular structures, while incorporating dipeptides capable of stablishing hydrogen bonds results in the adoption of advanced fibrilar structures. The self-assembly effect has proven to be key to achieve antimicrobial activity.
Short lipopeptides, that self-assemble into supramolecular structures, show antimicrobial activity. |
| doi_str_mv | 10.1039/d1ob01227d |
| format | Article |
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E. coli
) and Gram-positive (
S. aureus
) strains. This study shows that simple lipoamino acids self-assemble into micellar or vesicular structures, while incorporating dipeptides capable of stablishing hydrogen bonds results in the adoption of advanced fibrilar structures. The self-assembly effect has proven to be key to achieve antimicrobial activity.
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E. coli
) and Gram-positive (
S. aureus
) strains. This study shows that simple lipoamino acids self-assemble into micellar or vesicular structures, while incorporating dipeptides capable of stablishing hydrogen bonds results in the adoption of advanced fibrilar structures. The self-assembly effect has proven to be key to achieve antimicrobial activity.
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Herein, we report a library of 21 short lipopeptides, together with their supramolecular characterization and antimicrobial activity against both Gram-negative (
E. coli
) and Gram-positive (
S. aureus
) strains. This study shows that simple lipoamino acids self-assemble into micellar or vesicular structures, while incorporating dipeptides capable of stablishing hydrogen bonds results in the adoption of advanced fibrilar structures. The self-assembly effect has proven to be key to achieve antimicrobial activity.
Short lipopeptides, that self-assemble into supramolecular structures, show antimicrobial activity.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>34319330</pmid><doi>10.1039/d1ob01227d</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-5542-7034</orcidid><orcidid>https://orcid.org/0000-0002-0438-4887</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Organic & biomolecular chemistry, 2021-08, Vol.19 (31), p.6797-683 |
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| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antiinfectives and antibacterials Antimicrobial activity Antimicrobial agents Catalysis E coli Escherichia coli - drug effects Hydrogen bonding Hydrogen bonds Lipopeptides Lipopeptides - chemical synthesis Lipopeptides - chemistry Lipopeptides - pharmacology Microbial Sensitivity Tests Molecular Structure Nanotechnology Self-assembly Staphylococcus aureus - drug effects |
| title | New antimicrobial self-assembling short lipopeptides |
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