Longitudinal Outcomes Associated With Non-Evidence-Based Implantable Cardioverter-Defibrillators Among Medicare Beneficiaries (From the National Cardiovascular Data Registry)
Primary prevention implantable cardioverter-defibrillators (ICDs) in patients with recent myocardial infarction or coronary revascularization and those with newly diagnosed or severe heart failure (HF) are considered non-evidence-based, as defined by pivotal randomized clinical trials. Although non-...
Gespeichert in:
| Veröffentlicht in: | The American journal of cardiology 2021-09, Vol.155, p.64-71 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 71 |
|---|---|
| container_issue | |
| container_start_page | 64 |
| container_title | The American journal of cardiology |
| container_volume | 155 |
| creator | Daimee, Usama A. Aslam, Faisal Parzynski, Craig S. Desai, Nihar R. Curtis, Jeptha P. |
| description | Primary prevention implantable cardioverter-defibrillators (ICDs) in patients with recent myocardial infarction or coronary revascularization and those with newly diagnosed or severe heart failure (HF) are considered non-evidence-based, as defined by pivotal randomized clinical trials. Although non-evidence-based ICDs have been associated previously with greater risk of in-hospital adverse events, longitudinal outcomes are not known. We used Medicare-linked data from the National Cardiovascular Data Registry's ICD Registry to identify patients discharged alive following first-time primary prevention ICD implantations performed between 2010 and 2013. We compared longitudinal outcomes, including all-cause mortality and all-cause hospital readmission among patients receiving non-evidence-based versus evidence-based ICDs, up to 4.75 years after implantation, using multivariable time-to-event analyses. Of 71,666 ICD implantations, 9,609 (13.4%) were classified as non-evidence-based. Compared to patients receiving evidence-based ICDs, non-evidence-based ICD recipients had greater mortality risk at 90 days (HR = 1.44, CI: 1.37 – 1.52, p |
| doi_str_mv | 10.1016/j.amjcard.2021.06.020 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2555966636</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002914921005786</els_id><sourcerecordid>2555966636</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-d086081372e03f1b961dadd2e5c51eafb67980f4e28e0e6c856d0cba9308d3a03</originalsourceid><addsrcrecordid>eNqFkc1q3DAUhU1podM0j1AQdJMu7FzZY9lelWTyC9MEQkuX4lq6TmRsayrJA3mpPmNlZlbZdCUknfudezhJ8oVDxoGL8z7DsVfodJZDzjMQGeTwLlnxumpS3vDifbICgDxt-Lr5mHzyvo9XzkuxSv5u7fRswqzNhAN7nIOyI3l24b1VBgNp9tuEF_Zgp_R6bzRNitJL9PH9ftwNOAVsB2KbaG7snlwgl15RZ1pnhgGDdRE1Rgf2g7SJKxK7pCn-R7Yz0efsxtmRhRdiDxiMXXY4stCreUDHrjAge6Jn44N7_fY5-dDh4On0eJ4kv26uf27u0u3j7f3mYpuqooKQaqgF1LyocoKi420juEatcypVyQm7VlRNDd2a8pqAhKpLoUG12BRQ6wKhOEnODtyds39m8kGOxiuKmSays5d5WZaNEKIQUfr1jbS3s4tJFpXIS6jEuo6q8qBSznrvqJM7Z0Z0r5KDXFqUvTy2KJcWJQgZW4xz3w9zFNPuDTnplVla0MaRClJb8x_CPzypq2E</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2562507648</pqid></control><display><type>article</type><title>Longitudinal Outcomes Associated With Non-Evidence-Based Implantable Cardioverter-Defibrillators Among Medicare Beneficiaries (From the National Cardiovascular Data Registry)</title><source>Access via ScienceDirect (Elsevier)</source><source>ProQuest Central UK/Ireland</source><creator>Daimee, Usama A. ; Aslam, Faisal ; Parzynski, Craig S. ; Desai, Nihar R. ; Curtis, Jeptha P.</creator><creatorcontrib>Daimee, Usama A. ; Aslam, Faisal ; Parzynski, Craig S. ; Desai, Nihar R. ; Curtis, Jeptha P.</creatorcontrib><description>Primary prevention implantable cardioverter-defibrillators (ICDs) in patients with recent myocardial infarction or coronary revascularization and those with newly diagnosed or severe heart failure (HF) are considered non-evidence-based, as defined by pivotal randomized clinical trials. Although non-evidence-based ICDs have been associated previously with greater risk of in-hospital adverse events, longitudinal outcomes are not known. We used Medicare-linked data from the National Cardiovascular Data Registry's ICD Registry to identify patients discharged alive following first-time primary prevention ICD implantations performed between 2010 and 2013. We compared longitudinal outcomes, including all-cause mortality and all-cause hospital readmission among patients receiving non-evidence-based versus evidence-based ICDs, up to 4.75 years after implantation, using multivariable time-to-event analyses. Of 71,666 ICD implantations, 9,609 (13.4%) were classified as non-evidence-based. Compared to patients receiving evidence-based ICDs, non-evidence-based ICD recipients had greater mortality risk at 90 days (HR = 1.44, CI: 1.37 – 1.52, p <0.0001) and at 1 year (HR = 1.19, CI: 1.15 – 1.24, p <0.0001), but similar mortality risk at 3 years (HR = 1.03, CI: 0.98 – 1.08, p = 0.2630). Risk of all-cause hospitalization was higher in patients with non-evidence-based ICDs at 90 days (HR = 1.17, CI: 1.14 – 1.20, p <0.0001), but the difference diminished at 1 year (HR = 1.04, CI 1.00 – 1.07, p = 0.0272) and at 3 years (HR = 0.94, CI: 0.90 – 0.99, p = 0.0105). In conclusion, among patients undergoing primary prevention ICD implantations between 2010 and 2013, those with non-evidence-based ICDs were at increased risk of mortality and readmission during longitudinal follow-up. Differences in the risk of mortality and hospitalization were highest in the first year following device implantation.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2021.06.020</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>Adverse events ; Cerebrovascular disease ; Clinical trials ; Congestive heart failure ; Defibrillators ; Disease prevention ; Government programs ; Hospitalization ; Implantation ; Medicare ; Mortality ; Myocardial infarction ; Patients ; Prevention ; Risk ; Transplants & implants</subject><ispartof>The American journal of cardiology, 2021-09, Vol.155, p.64-71</ispartof><rights>2021 Elsevier Inc.</rights><rights>2021. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-d086081372e03f1b961dadd2e5c51eafb67980f4e28e0e6c856d0cba9308d3a03</citedby><cites>FETCH-LOGICAL-c370t-d086081372e03f1b961dadd2e5c51eafb67980f4e28e0e6c856d0cba9308d3a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2562507648?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids></links><search><creatorcontrib>Daimee, Usama A.</creatorcontrib><creatorcontrib>Aslam, Faisal</creatorcontrib><creatorcontrib>Parzynski, Craig S.</creatorcontrib><creatorcontrib>Desai, Nihar R.</creatorcontrib><creatorcontrib>Curtis, Jeptha P.</creatorcontrib><title>Longitudinal Outcomes Associated With Non-Evidence-Based Implantable Cardioverter-Defibrillators Among Medicare Beneficiaries (From the National Cardiovascular Data Registry)</title><title>The American journal of cardiology</title><description>Primary prevention implantable cardioverter-defibrillators (ICDs) in patients with recent myocardial infarction or coronary revascularization and those with newly diagnosed or severe heart failure (HF) are considered non-evidence-based, as defined by pivotal randomized clinical trials. Although non-evidence-based ICDs have been associated previously with greater risk of in-hospital adverse events, longitudinal outcomes are not known. We used Medicare-linked data from the National Cardiovascular Data Registry's ICD Registry to identify patients discharged alive following first-time primary prevention ICD implantations performed between 2010 and 2013. We compared longitudinal outcomes, including all-cause mortality and all-cause hospital readmission among patients receiving non-evidence-based versus evidence-based ICDs, up to 4.75 years after implantation, using multivariable time-to-event analyses. Of 71,666 ICD implantations, 9,609 (13.4%) were classified as non-evidence-based. Compared to patients receiving evidence-based ICDs, non-evidence-based ICD recipients had greater mortality risk at 90 days (HR = 1.44, CI: 1.37 – 1.52, p <0.0001) and at 1 year (HR = 1.19, CI: 1.15 – 1.24, p <0.0001), but similar mortality risk at 3 years (HR = 1.03, CI: 0.98 – 1.08, p = 0.2630). Risk of all-cause hospitalization was higher in patients with non-evidence-based ICDs at 90 days (HR = 1.17, CI: 1.14 – 1.20, p <0.0001), but the difference diminished at 1 year (HR = 1.04, CI 1.00 – 1.07, p = 0.0272) and at 3 years (HR = 0.94, CI: 0.90 – 0.99, p = 0.0105). In conclusion, among patients undergoing primary prevention ICD implantations between 2010 and 2013, those with non-evidence-based ICDs were at increased risk of mortality and readmission during longitudinal follow-up. Differences in the risk of mortality and hospitalization were highest in the first year following device implantation.</description><subject>Adverse events</subject><subject>Cerebrovascular disease</subject><subject>Clinical trials</subject><subject>Congestive heart failure</subject><subject>Defibrillators</subject><subject>Disease prevention</subject><subject>Government programs</subject><subject>Hospitalization</subject><subject>Implantation</subject><subject>Medicare</subject><subject>Mortality</subject><subject>Myocardial infarction</subject><subject>Patients</subject><subject>Prevention</subject><subject>Risk</subject><subject>Transplants & implants</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkc1q3DAUhU1podM0j1AQdJMu7FzZY9lelWTyC9MEQkuX4lq6TmRsayrJA3mpPmNlZlbZdCUknfudezhJ8oVDxoGL8z7DsVfodJZDzjMQGeTwLlnxumpS3vDifbICgDxt-Lr5mHzyvo9XzkuxSv5u7fRswqzNhAN7nIOyI3l24b1VBgNp9tuEF_Zgp_R6bzRNitJL9PH9ftwNOAVsB2KbaG7snlwgl15RZ1pnhgGDdRE1Rgf2g7SJKxK7pCn-R7Yz0efsxtmRhRdiDxiMXXY4stCreUDHrjAge6Jn44N7_fY5-dDh4On0eJ4kv26uf27u0u3j7f3mYpuqooKQaqgF1LyocoKi420juEatcypVyQm7VlRNDd2a8pqAhKpLoUG12BRQ6wKhOEnODtyds39m8kGOxiuKmSays5d5WZaNEKIQUfr1jbS3s4tJFpXIS6jEuo6q8qBSznrvqJM7Z0Z0r5KDXFqUvTy2KJcWJQgZW4xz3w9zFNPuDTnplVla0MaRClJb8x_CPzypq2E</recordid><startdate>20210915</startdate><enddate>20210915</enddate><creator>Daimee, Usama A.</creator><creator>Aslam, Faisal</creator><creator>Parzynski, Craig S.</creator><creator>Desai, Nihar R.</creator><creator>Curtis, Jeptha P.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7Z</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20210915</creationdate><title>Longitudinal Outcomes Associated With Non-Evidence-Based Implantable Cardioverter-Defibrillators Among Medicare Beneficiaries (From the National Cardiovascular Data Registry)</title><author>Daimee, Usama A. ; Aslam, Faisal ; Parzynski, Craig S. ; Desai, Nihar R. ; Curtis, Jeptha P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-d086081372e03f1b961dadd2e5c51eafb67980f4e28e0e6c856d0cba9308d3a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adverse events</topic><topic>Cerebrovascular disease</topic><topic>Clinical trials</topic><topic>Congestive heart failure</topic><topic>Defibrillators</topic><topic>Disease prevention</topic><topic>Government programs</topic><topic>Hospitalization</topic><topic>Implantation</topic><topic>Medicare</topic><topic>Mortality</topic><topic>Myocardial infarction</topic><topic>Patients</topic><topic>Prevention</topic><topic>Risk</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Daimee, Usama A.</creatorcontrib><creatorcontrib>Aslam, Faisal</creatorcontrib><creatorcontrib>Parzynski, Craig S.</creatorcontrib><creatorcontrib>Desai, Nihar R.</creatorcontrib><creatorcontrib>Curtis, Jeptha P.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biochemistry Abstracts 1</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Daimee, Usama A.</au><au>Aslam, Faisal</au><au>Parzynski, Craig S.</au><au>Desai, Nihar R.</au><au>Curtis, Jeptha P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal Outcomes Associated With Non-Evidence-Based Implantable Cardioverter-Defibrillators Among Medicare Beneficiaries (From the National Cardiovascular Data Registry)</atitle><jtitle>The American journal of cardiology</jtitle><date>2021-09-15</date><risdate>2021</risdate><volume>155</volume><spage>64</spage><epage>71</epage><pages>64-71</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><abstract>Primary prevention implantable cardioverter-defibrillators (ICDs) in patients with recent myocardial infarction or coronary revascularization and those with newly diagnosed or severe heart failure (HF) are considered non-evidence-based, as defined by pivotal randomized clinical trials. Although non-evidence-based ICDs have been associated previously with greater risk of in-hospital adverse events, longitudinal outcomes are not known. We used Medicare-linked data from the National Cardiovascular Data Registry's ICD Registry to identify patients discharged alive following first-time primary prevention ICD implantations performed between 2010 and 2013. We compared longitudinal outcomes, including all-cause mortality and all-cause hospital readmission among patients receiving non-evidence-based versus evidence-based ICDs, up to 4.75 years after implantation, using multivariable time-to-event analyses. Of 71,666 ICD implantations, 9,609 (13.4%) were classified as non-evidence-based. Compared to patients receiving evidence-based ICDs, non-evidence-based ICD recipients had greater mortality risk at 90 days (HR = 1.44, CI: 1.37 – 1.52, p <0.0001) and at 1 year (HR = 1.19, CI: 1.15 – 1.24, p <0.0001), but similar mortality risk at 3 years (HR = 1.03, CI: 0.98 – 1.08, p = 0.2630). Risk of all-cause hospitalization was higher in patients with non-evidence-based ICDs at 90 days (HR = 1.17, CI: 1.14 – 1.20, p <0.0001), but the difference diminished at 1 year (HR = 1.04, CI 1.00 – 1.07, p = 0.0272) and at 3 years (HR = 0.94, CI: 0.90 – 0.99, p = 0.0105). In conclusion, among patients undergoing primary prevention ICD implantations between 2010 and 2013, those with non-evidence-based ICDs were at increased risk of mortality and readmission during longitudinal follow-up. Differences in the risk of mortality and hospitalization were highest in the first year following device implantation.</abstract><cop>New York</cop><pub>Elsevier Inc</pub><doi>10.1016/j.amjcard.2021.06.020</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9149 |
| ispartof | The American journal of cardiology, 2021-09, Vol.155, p.64-71 |
| issn | 0002-9149 1879-1913 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2555966636 |
| source | Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
| subjects | Adverse events Cerebrovascular disease Clinical trials Congestive heart failure Defibrillators Disease prevention Government programs Hospitalization Implantation Medicare Mortality Myocardial infarction Patients Prevention Risk Transplants & implants |
| title | Longitudinal Outcomes Associated With Non-Evidence-Based Implantable Cardioverter-Defibrillators Among Medicare Beneficiaries (From the National Cardiovascular Data Registry) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T20%3A09%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Longitudinal%20Outcomes%20Associated%20With%20Non-Evidence-Based%20Implantable%20Cardioverter-Defibrillators%20Among%20Medicare%20Beneficiaries%20(From%20the%20National%20Cardiovascular%20Data%20Registry)&rft.jtitle=The%20American%20journal%20of%20cardiology&rft.au=Daimee,%20Usama%20A.&rft.date=2021-09-15&rft.volume=155&rft.spage=64&rft.epage=71&rft.pages=64-71&rft.issn=0002-9149&rft.eissn=1879-1913&rft_id=info:doi/10.1016/j.amjcard.2021.06.020&rft_dat=%3Cproquest_cross%3E2555966636%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2562507648&rft_id=info:pmid/&rft_els_id=S0002914921005786&rfr_iscdi=true |