Protein Kinase N Family Negatively Regulates Constitutive Androstane Receptor-Mediated Transcriptional Induction of Cytochrome P450 2b10 in the Livers of Mice

In receptor-type transcription factors-mediated cytochrome P450 (P450) induction, few studies have attempted to clarify the roles of protein kinase N (PKN) in the transcriptional regulation of P450s. This study aimed to examine the involvement of PKN in the transcriptional regulation of P450s by rec...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2021-10, Vol.379 (1), p.53-63
Hauptverfasser:	Kawase, Atsushi, Mukai, Hideyuki, Tateishi, Shunsuke, Kuroda, Shintaro, Kazaoka, Akira, Satoh, Ryosuke, Shimada, Hiroaki, Sugiura, Reiko, Iwaki, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aryl Hydrocarbon Hydroxylases - genetics Aryl Hydrocarbon Hydroxylases - metabolism Constitutive Androstane Receptor - metabolism Cytochrome P450 Family 2 - genetics Cytochrome P450 Family 2 - metabolism Enzyme Induction - drug effects Enzyme Induction - physiology Liver - drug effects Liver - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Microsomes, Liver - drug effects Microsomes, Liver - metabolism Protein Kinase C - metabolism Steroid Hydroxylases - genetics Steroid Hydroxylases - metabolism Transcription, Genetic - drug effects Transcription, Genetic - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!