$Prospecting for natural products by genome mining and microcrystal electron diffraction$

Prospecting for natural products by genome mining and microcrystal electron diffraction

More than 60% of pharmaceuticals are related to natural products (NPs), chemicals produced by living organisms. Despite this, the rate of NP discovery has slowed over the past few decades. In many cases the rate-limiting step in NP discovery is structural characterization. Here we report the use of...

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Veröffentlicht in:	Nature chemical biology 2021-08, Vol.17 (8), p.872-877
Hauptverfasser:	Kim, Lee Joon, Ohashi, Masao, Zhang, Zhuan, Tan, Dan, Asay, Matthew, Cascio, Duilio, Rodriguez, José A., Tang, Yi, Nelson, Hosea M.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/2258 631/92/349 631/92/60 Biochemical Engineering Biochemistry Bioorganic Chemistry Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science Cytotoxicity Electron diffraction Electron microscopy Exploration Gene clusters Genomes Microcrystals Natural products Structural analysis Toxicity
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