Discovery of Antitumor Active Peptides Derived from Peroxiredoxin 5

The peroxiredoxin 5 (PRDX5) is a member of peroxiredoxins with antitumor activity. However, as a recombinant protein, PRDX5 is restricted in clinic due to high cost and keeping high dose in medication. The alternative way is to explore the antitumor active fragments of PRDX5 for potential of peptide...

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Veröffentlicht in:	ChemMedChem 2021-11, Vol.16 (22), p.3477-3483
Hauptverfasser:	Liu, Juanjuan, Zou, Sen, Zhang, Yan, Lin, Ru, Duan, Yanbo, He, Weiqing, Yang, Zhaoyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anticancer properties Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology antioxidation Antitumor activity antitumor agents Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Crystal structure Drug Screening Assays, Antitumor Gene expression Gene regulation Genes Humans Oxidation Peptides Peptides - chemical synthesis Peptides - chemistry Peptides - pharmacology Peroxiredoxin peroxiredoxin-5 Peroxiredoxins - chemistry Protein Conformation Sequence Alignment Structure-function relationships transcriptome analysis Transcriptomes Tumorigenesis
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