Dilithium Amides as a Modular Bis-Anionic Ligand Platform for Iron-Catalyzed Cross-Coupling

Dilithium Amides as a Modular Bis-Anionic Ligand Platform for Iron-Catalyzed Cross-Coupling

Dilithium amides have been developed as a bespoke and general ligand for iron-catalyzed Kumada–Tamao–Corriu cross-coupling reactions, their design taking inspiration from previous mechanistic and structural studies. They allow for the cross-coupling of alkyl Grignard reagents with sp2-hybridized ele...

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Veröffentlicht in:Organic letters 2021-08, Vol.23 (15), p.5958-5963
Hauptverfasser: Neate, Peter G. N, Zhang, Bufan, Conforti, Jessica, Brennessel, William W, Neidig, Michael L
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container_end_page 5963
container_issue 15
container_start_page 5958
container_title Organic letters
container_volume 23
creator Neate, Peter G. N
Zhang, Bufan
Conforti, Jessica
Brennessel, William W
Neidig, Michael L
description Dilithium amides have been developed as a bespoke and general ligand for iron-catalyzed Kumada–Tamao–Corriu cross-coupling reactions, their design taking inspiration from previous mechanistic and structural studies. They allow for the cross-coupling of alkyl Grignard reagents with sp2-hybridized electrophiles as well as aryl Grignard reagents with sp3-hybridized electrophiles. This represents a rare example of a single iron-catalyzed system effective across diverse coupling reactions without significant modification of the catalytic protocol, as well as remaining operationally simple.
doi_str_mv 10.1021/acs.orglett.1c02053
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title Dilithium Amides as a Modular Bis-Anionic Ligand Platform for Iron-Catalyzed Cross-Coupling
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