Rational Multitargeted Drug Design Strategy from the Perspective of a Medicinal Chemist

The development of multitarget-directed ligands (MTDLs) has become a widely focused research topic, but rational design remains as an enormous challenge. This paper reviews and discusses the design strategy of incorporating the second activity into an existing single-active ligand. If the binding si...

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Veröffentlicht in:	Journal of medicinal chemistry 2021-08, Vol.64 (15), p.10581-10605
Hauptverfasser:	Li, Xiangqian, Li, Xiaowei, Liu, Fang, Li, Shuo, Shi, Dayong
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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