Three-Pot Synthesis of Chiral Anti-1,3-diols through Asymmetric Organocatalytic Aldol and Wittig Reactions Followed by Epoxidation and Reductive Opening of the Epoxide

A three-pot asymmetric synthesis of the anti-1,3-diol unit was developed. In the first pot, enantioselective aldol reaction of aldehydes proceeds, catalyzed by organocatalyst, followed by either Wittig or Horner–Wadsworth–Emmons reactions to afford δ-hydroxy α,β-unsaturated carbonyls with excellent...

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Veröffentlicht in:	Organic letters 2021-08, Vol.23 (15), p.5896-5900
Hauptverfasser:	Hayashi, Yujiro, Tomikawa, Masashi, Mori, Naoki
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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