Asymmetric Synthesis of Fluorinated Allenes by Rhodium‐Catalyzed Enantioselective Alkylation/Defluorination of Propargyl Difluorides with Alkylzincs

The reaction of propargyl difluorides R1CF2C≡CR2 with alkylzincs R3ZnCl giving axially chiral fluorinated allenes R1FC=C=CR2R3 with high enantioselectivity (up to 99 % ee) was found to be catalyzed by a chiral diene/rhodium complex. A key step in the catalytic cycle is selective elimination of one o...

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Veröffentlicht in:	Angewandte Chemie International Edition 2021-09, Vol.60 (38), p.20771-20775
Hauptverfasser:	Ng, Jia Sheng, Hayashi, Tamio
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation asymmetric defluorination Asymmetric synthesis axially chiral allenes Chemical bonds Chemical synthesis chiral diene ligands Defluorination Difluorides Enantiomers enantioselectivity Fluorides Fluorination Rhodium
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