IRF6 Regulates the Delivery of E-Cadherin to the Plasma Membrane

IRF6 is a transcription factor that is required for craniofacial development and epidermal morphogenesis. Specifically, Irf6-deficient mice lack the terminally differentiated epidermal layers, leading to an absence of barrier function. This phenotype also includes intraoral adhesions due to the abse...

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Veröffentlicht in:	Journal of investigative dermatology 2022-02, Vol.142 (2), p.314-322
Hauptverfasser:	Antiguas, Angelo, DeMali, Kris A., Dunnwald, Martine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - metabolism Cadherins - metabolism Cell Adhesion - drug effects Cell Line Cell Membrane - drug effects Cell Membrane - metabolism Dynamins - antagonists & inhibitors Dynamins - metabolism Endocytosis - drug effects Gene Knockdown Techniques Humans Hydrazones - pharmacology Intercellular Junctions - drug effects Intercellular Junctions - metabolism Interferon Regulatory Factors - genetics Interferon Regulatory Factors - metabolism Keratinocytes - drug effects Keratinocytes - metabolism Mice Naphthols - pharmacology Primary Cell Culture Stress, Mechanical
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