Mutational profiles of metastatic colorectal cancer treated with FOLFIRI plus cetuximab or bevacizumab before and after secondary resection (AIO KRK 0306; FIRE‐3)

Secondary resection of metastases is recommended in metastatic colorectal cancer (mCRC). Data describing changes in mutational profiles of corresponding primary tumor and metastatic tissue after conversion treatment are limited. Next generation sequencing was performed in formalin‐fixed mCRC samples...

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Veröffentlicht in:	International journal of cancer 2021-12, Vol.149 (11), p.1935-1943
Hauptverfasser:	Stahler, Arndt, Heinemann, Volker, Holch, Julian Walter, Einem, Jobst Christian, Westphalen, Christoph Benedikt, Heinrich, Kathrin, Schlieker, Laura, Jelas, Ivan, Alig, Annabel Helga Sophie, Fischer, Laura Elisabeth, Weiss, Lena, Modest, Dominik Paul, Weikersthal, Ludwig Fischer, Decker, Thomas, Kiani, Alexander, Moehler, Markus, Kaiser, Florian, Kirchner, Thomas, Jung, Andreas, Stintzing, Sebastian
Format:	Artikel
Sprache:	eng
Schlagworte:	Bevacizumab Cancer cetuximab Colorectal cancer Colorectal carcinoma Epidermal growth factor receptors Medical research Metastases Metastasis metastatic colorectal cancer Monoclonal antibodies Next-generation sequencing NGS paired samples Patients Survival Targeted cancer therapy Vascular endothelial growth factor
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