Sample size calculation for recurrent event data with additive rates models

This paper discusses the design of clinical trials where the primary endpoint is a recurrent event with the focus on the sample size calculation. For the problem, a few methods have been proposed but most of them assume a multiplicative treatment effect on the rate or mean number of recurrent events...

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Veröffentlicht in:	Pharmaceutical statistics : the journal of the pharmaceutical industry 2022-01, Vol.21 (1), p.89-102
Hauptverfasser:	Zhu, Liang, Li, Yimei, Tang, Yongqiang, Shen, Liji, Onar‐Thomas, Arzu, Sun, Jianguo
Format:	Artikel
Sprache:	eng
Schlagworte:	additive rates models Clinical trials Computer Simulation Humans Models, Statistical overdispersion Pharmaceuticals Recurrence recurrent event Sample Size sample size calculation sandwich variance
Online-Zugang:	Volltext
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