Genetic interaction between F‐box motif encoding YDR131C and retrograde signaling‐related RTG1 regulates the stress response and apoptosis in Saccharomyces cerevisiae
The retrograde signaling pathway is well conserved from yeast to humans, which regulates cell adaptation during stress conditions and prevents cell death. One of its components, RTG1 encoded Rtg1p in association with Rtg3p communicates between mitochondria, nucleus, and peroxisome during stress for...
Gespeichert in:
| Veröffentlicht in: | Journal of biochemical and molecular toxicology 2021-10, Vol.35 (10), p.e22864-n/a |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 10 |
| container_start_page | e22864 |
| container_title | Journal of biochemical and molecular toxicology |
| container_volume | 35 |
| creator | Shoket, Heena Pandita, Monika Sharma, Meenu Kumar, Ravinder Rakwal, Ayushi Wazir, Shreya Verma, Vijeshwar Salunke, Deepak B. Bairwa, Narendra K. |
| description | The retrograde signaling pathway is well conserved from yeast to humans, which regulates cell adaptation during stress conditions and prevents cell death. One of its components, RTG1 encoded Rtg1p in association with Rtg3p communicates between mitochondria, nucleus, and peroxisome during stress for adaptation, by regulation of transcription. The F‐box motif protein encoded by YDR131C constitutes a part of SCF Ydr131c‐E3 ligase complex, with unknown function; however, it is known that retrograde signaling is modulated by the E3 ligase complex. This study reports epistasis interaction between YDR131C and RTG1, which regulates cell growth, response to genotoxic stress, decreased apoptosis, resistance to petite mutation, and cell wall integrity. The cells of ydr131cΔrtg1Δ genetic background exhibits growth rate improvement however, sensitivity to hydroxyurea, itraconazole antifungal agent and synthetic indoloquinazoline‐based alkaloid (8‐fluorotryptanthrin, RK64), which disrupts the cell wall integrity in Saccharomyces cerevisiae. The epistatic interaction between YDR131C and RTG1 indicates a link between protein degradation and retrograde signaling pathways. |
| doi_str_mv | 10.1002/jbt.22864 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2555347151</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2582047091</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3534-3367b233acbd6d015608c1804920001e8083174f9534c8ee1e912a5bd23815c53</originalsourceid><addsrcrecordid>eNp10ctu1DAUBmALUdFSWPACyBIbWKT1Jc5lCUM7LaqEVIYFq8hxzkw9SuzUdmhnxyPwHDwWT9IzM4UFEivH0Xd-Wf8h5BVnJ5wxcbpu04kQVZE_IUec1XXG8oI_3X2rrChKdkiex7hmjKm6VM_Iocwlq7ngR-TXHBwka6h1CYI2yXpHW0h3AI6e__7xs_X3dPDJLik44zvrVvTbx2su-Yxq19EAKfhV0B3QaFdO9whwKkCvE3T0ejHnaFbT9hppukGWAsSIP-PoXYRdih79mHy0EZ9Bv2hjbnTww8bgiIEA3220Gl6Qg6XuI7x8PI_J1_Ozxewiu_o8v5y9v8qMVDLPpCzKVkipTdsVHeOqYJXhFctrgQVwqFgleZkva8SmAuCATWjVdkJWXBklj8nbfe4Y_O0EMTWDjQb6XjvwU2yEUjhacsWRvvmHrv0UsIWtqgTLS6wZ1bu9MsHHGGDZjMEOOmwazprtAhtcYLNbINrXj4lTO0D3V_7ZGILTPbizPWz-n9R8-rDYRz4AkZOnVQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2582047091</pqid></control><display><type>article</type><title>Genetic interaction between F‐box motif encoding YDR131C and retrograde signaling‐related RTG1 regulates the stress response and apoptosis in Saccharomyces cerevisiae</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Shoket, Heena ; Pandita, Monika ; Sharma, Meenu ; Kumar, Ravinder ; Rakwal, Ayushi ; Wazir, Shreya ; Verma, Vijeshwar ; Salunke, Deepak B. ; Bairwa, Narendra K.</creator><creatorcontrib>Shoket, Heena ; Pandita, Monika ; Sharma, Meenu ; Kumar, Ravinder ; Rakwal, Ayushi ; Wazir, Shreya ; Verma, Vijeshwar ; Salunke, Deepak B. ; Bairwa, Narendra K.</creatorcontrib><description>The retrograde signaling pathway is well conserved from yeast to humans, which regulates cell adaptation during stress conditions and prevents cell death. One of its components, RTG1 encoded Rtg1p in association with Rtg3p communicates between mitochondria, nucleus, and peroxisome during stress for adaptation, by regulation of transcription. The F‐box motif protein encoded by YDR131C constitutes a part of SCF Ydr131c‐E3 ligase complex, with unknown function; however, it is known that retrograde signaling is modulated by the E3 ligase complex. This study reports epistasis interaction between YDR131C and RTG1, which regulates cell growth, response to genotoxic stress, decreased apoptosis, resistance to petite mutation, and cell wall integrity. The cells of ydr131cΔrtg1Δ genetic background exhibits growth rate improvement however, sensitivity to hydroxyurea, itraconazole antifungal agent and synthetic indoloquinazoline‐based alkaloid (8‐fluorotryptanthrin, RK64), which disrupts the cell wall integrity in Saccharomyces cerevisiae. The epistatic interaction between YDR131C and RTG1 indicates a link between protein degradation and retrograde signaling pathways.</description><identifier>ISSN: 1095-6670</identifier><identifier>EISSN: 1099-0461</identifier><identifier>DOI: 10.1002/jbt.22864</identifier><identifier>PMID: 34309121</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>8‐fluorotryptanthrin ; Acetic Acid - pharmacology ; Adaptation ; Antifungal agents ; Antifungal Agents - pharmacology ; anti‐fungal Itraconazole ; Apoptosis ; Apoptosis - drug effects ; Apoptosis - genetics ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism ; Cell death ; Cell Enlargement - drug effects ; Cell Size - drug effects ; Cell walls ; DNA Damage - drug effects ; DNA Damage - genetics ; Epistasis ; Epistasis, Genetic ; Ethidium - pharmacology ; F-Box Motifs - genetics ; Fungicides ; F‐box motif ; Gene Deletion ; Gene Expression Regulation, Fungal ; Gene regulation ; Genotoxicity ; Growth rate ; Hydrogen Peroxide - pharmacology ; Hydroxyurea ; Hydroxyurea - pharmacology ; Integrity ; Itraconazole ; Itraconazole - pharmacology ; Microorganisms, Genetically-Modified ; Mitochondria ; Mutation ; Mutation - drug effects ; Proteins ; Retrograde transport ; S. cerevisiae ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - genetics ; Saccharomyces cerevisiae - metabolism ; Saccharomyces cerevisiae Proteins - genetics ; Saccharomyces cerevisiae Proteins - metabolism ; Signal transduction ; Signal Transduction - genetics ; Signaling ; stress agents ; Sulfinic Acids - pharmacology ; Transcription ; Ubiquitin-protein ligase ; Yeast ; Yeasts</subject><ispartof>Journal of biochemical and molecular toxicology, 2021-10, Vol.35 (10), p.e22864-n/a</ispartof><rights>2021 Wiley Periodicals LLC</rights><rights>2021 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3534-3367b233acbd6d015608c1804920001e8083174f9534c8ee1e912a5bd23815c53</citedby><cites>FETCH-LOGICAL-c3534-3367b233acbd6d015608c1804920001e8083174f9534c8ee1e912a5bd23815c53</cites><orcidid>0000-0003-3097-0617</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbt.22864$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbt.22864$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34309121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shoket, Heena</creatorcontrib><creatorcontrib>Pandita, Monika</creatorcontrib><creatorcontrib>Sharma, Meenu</creatorcontrib><creatorcontrib>Kumar, Ravinder</creatorcontrib><creatorcontrib>Rakwal, Ayushi</creatorcontrib><creatorcontrib>Wazir, Shreya</creatorcontrib><creatorcontrib>Verma, Vijeshwar</creatorcontrib><creatorcontrib>Salunke, Deepak B.</creatorcontrib><creatorcontrib>Bairwa, Narendra K.</creatorcontrib><title>Genetic interaction between F‐box motif encoding YDR131C and retrograde signaling‐related RTG1 regulates the stress response and apoptosis in Saccharomyces cerevisiae</title><title>Journal of biochemical and molecular toxicology</title><addtitle>J Biochem Mol Toxicol</addtitle><description>The retrograde signaling pathway is well conserved from yeast to humans, which regulates cell adaptation during stress conditions and prevents cell death. One of its components, RTG1 encoded Rtg1p in association with Rtg3p communicates between mitochondria, nucleus, and peroxisome during stress for adaptation, by regulation of transcription. The F‐box motif protein encoded by YDR131C constitutes a part of SCF Ydr131c‐E3 ligase complex, with unknown function; however, it is known that retrograde signaling is modulated by the E3 ligase complex. This study reports epistasis interaction between YDR131C and RTG1, which regulates cell growth, response to genotoxic stress, decreased apoptosis, resistance to petite mutation, and cell wall integrity. The cells of ydr131cΔrtg1Δ genetic background exhibits growth rate improvement however, sensitivity to hydroxyurea, itraconazole antifungal agent and synthetic indoloquinazoline‐based alkaloid (8‐fluorotryptanthrin, RK64), which disrupts the cell wall integrity in Saccharomyces cerevisiae. The epistatic interaction between YDR131C and RTG1 indicates a link between protein degradation and retrograde signaling pathways.</description><subject>8‐fluorotryptanthrin</subject><subject>Acetic Acid - pharmacology</subject><subject>Adaptation</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - pharmacology</subject><subject>anti‐fungal Itraconazole</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - genetics</subject><subject>Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics</subject><subject>Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism</subject><subject>Cell death</subject><subject>Cell Enlargement - drug effects</subject><subject>Cell Size - drug effects</subject><subject>Cell walls</subject><subject>DNA Damage - drug effects</subject><subject>DNA Damage - genetics</subject><subject>Epistasis</subject><subject>Epistasis, Genetic</subject><subject>Ethidium - pharmacology</subject><subject>F-Box Motifs - genetics</subject><subject>Fungicides</subject><subject>F‐box motif</subject><subject>Gene Deletion</subject><subject>Gene Expression Regulation, Fungal</subject><subject>Gene regulation</subject><subject>Genotoxicity</subject><subject>Growth rate</subject><subject>Hydrogen Peroxide - pharmacology</subject><subject>Hydroxyurea</subject><subject>Hydroxyurea - pharmacology</subject><subject>Integrity</subject><subject>Itraconazole</subject><subject>Itraconazole - pharmacology</subject><subject>Microorganisms, Genetically-Modified</subject><subject>Mitochondria</subject><subject>Mutation</subject><subject>Mutation - drug effects</subject><subject>Proteins</subject><subject>Retrograde transport</subject><subject>S. cerevisiae</subject><subject>Saccharomyces cerevisiae</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Saccharomyces cerevisiae - metabolism</subject><subject>Saccharomyces cerevisiae Proteins - genetics</subject><subject>Saccharomyces cerevisiae Proteins - metabolism</subject><subject>Signal transduction</subject><subject>Signal Transduction - genetics</subject><subject>Signaling</subject><subject>stress agents</subject><subject>Sulfinic Acids - pharmacology</subject><subject>Transcription</subject><subject>Ubiquitin-protein ligase</subject><subject>Yeast</subject><subject>Yeasts</subject><issn>1095-6670</issn><issn>1099-0461</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10ctu1DAUBmALUdFSWPACyBIbWKT1Jc5lCUM7LaqEVIYFq8hxzkw9SuzUdmhnxyPwHDwWT9IzM4UFEivH0Xd-Wf8h5BVnJ5wxcbpu04kQVZE_IUec1XXG8oI_3X2rrChKdkiex7hmjKm6VM_Iocwlq7ngR-TXHBwka6h1CYI2yXpHW0h3AI6e__7xs_X3dPDJLik44zvrVvTbx2su-Yxq19EAKfhV0B3QaFdO9whwKkCvE3T0ejHnaFbT9hppukGWAsSIP-PoXYRdih79mHy0EZ9Bv2hjbnTww8bgiIEA3220Gl6Qg6XuI7x8PI_J1_Ozxewiu_o8v5y9v8qMVDLPpCzKVkipTdsVHeOqYJXhFctrgQVwqFgleZkva8SmAuCATWjVdkJWXBklj8nbfe4Y_O0EMTWDjQb6XjvwU2yEUjhacsWRvvmHrv0UsIWtqgTLS6wZ1bu9MsHHGGDZjMEOOmwazprtAhtcYLNbINrXj4lTO0D3V_7ZGILTPbizPWz-n9R8-rDYRz4AkZOnVQ</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Shoket, Heena</creator><creator>Pandita, Monika</creator><creator>Sharma, Meenu</creator><creator>Kumar, Ravinder</creator><creator>Rakwal, Ayushi</creator><creator>Wazir, Shreya</creator><creator>Verma, Vijeshwar</creator><creator>Salunke, Deepak B.</creator><creator>Bairwa, Narendra K.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3097-0617</orcidid></search><sort><creationdate>202110</creationdate><title>Genetic interaction between F‐box motif encoding YDR131C and retrograde signaling‐related RTG1 regulates the stress response and apoptosis in Saccharomyces cerevisiae</title><author>Shoket, Heena ; Pandita, Monika ; Sharma, Meenu ; Kumar, Ravinder ; Rakwal, Ayushi ; Wazir, Shreya ; Verma, Vijeshwar ; Salunke, Deepak B. ; Bairwa, Narendra K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3534-3367b233acbd6d015608c1804920001e8083174f9534c8ee1e912a5bd23815c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>8‐fluorotryptanthrin</topic><topic>Acetic Acid - pharmacology</topic><topic>Adaptation</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - pharmacology</topic><topic>anti‐fungal Itraconazole</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis - genetics</topic><topic>Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics</topic><topic>Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism</topic><topic>Cell death</topic><topic>Cell Enlargement - drug effects</topic><topic>Cell Size - drug effects</topic><topic>Cell walls</topic><topic>DNA Damage - drug effects</topic><topic>DNA Damage - genetics</topic><topic>Epistasis</topic><topic>Epistasis, Genetic</topic><topic>Ethidium - pharmacology</topic><topic>F-Box Motifs - genetics</topic><topic>Fungicides</topic><topic>F‐box motif</topic><topic>Gene Deletion</topic><topic>Gene Expression Regulation, Fungal</topic><topic>Gene regulation</topic><topic>Genotoxicity</topic><topic>Growth rate</topic><topic>Hydrogen Peroxide - pharmacology</topic><topic>Hydroxyurea</topic><topic>Hydroxyurea - pharmacology</topic><topic>Integrity</topic><topic>Itraconazole</topic><topic>Itraconazole - pharmacology</topic><topic>Microorganisms, Genetically-Modified</topic><topic>Mitochondria</topic><topic>Mutation</topic><topic>Mutation - drug effects</topic><topic>Proteins</topic><topic>Retrograde transport</topic><topic>S. cerevisiae</topic><topic>Saccharomyces cerevisiae</topic><topic>Saccharomyces cerevisiae - genetics</topic><topic>Saccharomyces cerevisiae - metabolism</topic><topic>Saccharomyces cerevisiae Proteins - genetics</topic><topic>Saccharomyces cerevisiae Proteins - metabolism</topic><topic>Signal transduction</topic><topic>Signal Transduction - genetics</topic><topic>Signaling</topic><topic>stress agents</topic><topic>Sulfinic Acids - pharmacology</topic><topic>Transcription</topic><topic>Ubiquitin-protein ligase</topic><topic>Yeast</topic><topic>Yeasts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shoket, Heena</creatorcontrib><creatorcontrib>Pandita, Monika</creatorcontrib><creatorcontrib>Sharma, Meenu</creatorcontrib><creatorcontrib>Kumar, Ravinder</creatorcontrib><creatorcontrib>Rakwal, Ayushi</creatorcontrib><creatorcontrib>Wazir, Shreya</creatorcontrib><creatorcontrib>Verma, Vijeshwar</creatorcontrib><creatorcontrib>Salunke, Deepak B.</creatorcontrib><creatorcontrib>Bairwa, Narendra K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biochemical and molecular toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shoket, Heena</au><au>Pandita, Monika</au><au>Sharma, Meenu</au><au>Kumar, Ravinder</au><au>Rakwal, Ayushi</au><au>Wazir, Shreya</au><au>Verma, Vijeshwar</au><au>Salunke, Deepak B.</au><au>Bairwa, Narendra K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic interaction between F‐box motif encoding YDR131C and retrograde signaling‐related RTG1 regulates the stress response and apoptosis in Saccharomyces cerevisiae</atitle><jtitle>Journal of biochemical and molecular toxicology</jtitle><addtitle>J Biochem Mol Toxicol</addtitle><date>2021-10</date><risdate>2021</risdate><volume>35</volume><issue>10</issue><spage>e22864</spage><epage>n/a</epage><pages>e22864-n/a</pages><issn>1095-6670</issn><eissn>1099-0461</eissn><abstract>The retrograde signaling pathway is well conserved from yeast to humans, which regulates cell adaptation during stress conditions and prevents cell death. One of its components, RTG1 encoded Rtg1p in association with Rtg3p communicates between mitochondria, nucleus, and peroxisome during stress for adaptation, by regulation of transcription. The F‐box motif protein encoded by YDR131C constitutes a part of SCF Ydr131c‐E3 ligase complex, with unknown function; however, it is known that retrograde signaling is modulated by the E3 ligase complex. This study reports epistasis interaction between YDR131C and RTG1, which regulates cell growth, response to genotoxic stress, decreased apoptosis, resistance to petite mutation, and cell wall integrity. The cells of ydr131cΔrtg1Δ genetic background exhibits growth rate improvement however, sensitivity to hydroxyurea, itraconazole antifungal agent and synthetic indoloquinazoline‐based alkaloid (8‐fluorotryptanthrin, RK64), which disrupts the cell wall integrity in Saccharomyces cerevisiae. The epistatic interaction between YDR131C and RTG1 indicates a link between protein degradation and retrograde signaling pathways.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34309121</pmid><doi>10.1002/jbt.22864</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-3097-0617</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1095-6670 |
| ispartof | Journal of biochemical and molecular toxicology, 2021-10, Vol.35 (10), p.e22864-n/a |
| issn | 1095-6670 1099-0461 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2555347151 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | 8‐fluorotryptanthrin Acetic Acid - pharmacology Adaptation Antifungal agents Antifungal Agents - pharmacology anti‐fungal Itraconazole Apoptosis Apoptosis - drug effects Apoptosis - genetics Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism Cell death Cell Enlargement - drug effects Cell Size - drug effects Cell walls DNA Damage - drug effects DNA Damage - genetics Epistasis Epistasis, Genetic Ethidium - pharmacology F-Box Motifs - genetics Fungicides F‐box motif Gene Deletion Gene Expression Regulation, Fungal Gene regulation Genotoxicity Growth rate Hydrogen Peroxide - pharmacology Hydroxyurea Hydroxyurea - pharmacology Integrity Itraconazole Itraconazole - pharmacology Microorganisms, Genetically-Modified Mitochondria Mutation Mutation - drug effects Proteins Retrograde transport S. cerevisiae Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Signal transduction Signal Transduction - genetics Signaling stress agents Sulfinic Acids - pharmacology Transcription Ubiquitin-protein ligase Yeast Yeasts |
| title | Genetic interaction between F‐box motif encoding YDR131C and retrograde signaling‐related RTG1 regulates the stress response and apoptosis in Saccharomyces cerevisiae |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-30T14%3A36%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20interaction%20between%20F%E2%80%90box%20motif%20encoding%20YDR131C%20and%20retrograde%20signaling%E2%80%90related%20RTG1%20regulates%20the%20stress%20response%20and%20apoptosis%20in%20Saccharomyces%20cerevisiae&rft.jtitle=Journal%20of%20biochemical%20and%20molecular%20toxicology&rft.au=Shoket,%20Heena&rft.date=2021-10&rft.volume=35&rft.issue=10&rft.spage=e22864&rft.epage=n/a&rft.pages=e22864-n/a&rft.issn=1095-6670&rft.eissn=1099-0461&rft_id=info:doi/10.1002/jbt.22864&rft_dat=%3Cproquest_cross%3E2582047091%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2582047091&rft_id=info:pmid/34309121&rfr_iscdi=true |