Evaluation of the effect of unilateral late blindness on the retina, optic nerve and choroid parameters in the sighted eye
Background To investigate whether unilateral late blindness alters the peripapillary retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), central macular thickness (CMT) and choroidal thickness (CT). Methods The 17 healthy eyes of 17 monocular patients with late blindness due to isolated e...
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| Veröffentlicht in: | International ophthalmology 2021-12, Vol.41 (12), p.4083-4089 |
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| creator | Oktem, Caglar Aslan, Fatih Oktem, Ece Ozdemir |
| description | Background
To investigate whether unilateral late blindness alters the peripapillary retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), central macular thickness (CMT) and choroidal thickness (CT).
Methods
The 17 healthy eyes of 17 monocular patients with late blindness due to isolated eye trauma in one eye and the 19 eyes of 19 healthy individuals were evaluated in this retrospective study. Patients with at least 10 years of monocular blindness, a refractive error between + 1.5 and -1.5 D in the sighted eye, a best-corrected visual acuity of at least 20/20 and an axial length (AL) |
| doi_str_mv | 10.1007/s10792-021-01981-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2555346846</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2594368982</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-3658ebd620efff6165657161577888dbb69f27cd809cc07a12a65437b18a548d3</originalsourceid><addsrcrecordid>eNp9kUtr3TAQhUVpobdp_kBWgm66qJORbD28DCEvCHSTrIUsj3MVfKVbSQ6kvz66caCQRTczDHznMIdDyAmDUwagzjID1fMGOGuA9brOT2TDhGobLlv4TDbApGiEAvaVfMv5CQB61csN-Xv5bOfFFh8DjRMtW6Q4TejK4VqCn23BZGd62HSYfRgD5kwrfUATFh_sLxr3xTsaMD0jtWGkbhtT9CPd22R3WB0y9asi-8dtwZHiC34nXyY7Zzx-30fk4ery_uKmuft9fXtxfte4junStFJoHEbJoT42yZpDCsVkDae01uMwyH7iyo0aeudAWcatFF2rBqat6PTYHpGfq-8-xT8L5mJ2PjucZxswLtlwIUTbSd3Jiv74gD7FJYX6XaX6rpW617xSfKVcijknnMw--Z1NL4aBOdRh1jpMrcO81WGgitpVlCscHjH9s_6P6hXB041B</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2594368982</pqid></control><display><type>article</type><title>Evaluation of the effect of unilateral late blindness on the retina, optic nerve and choroid parameters in the sighted eye</title><source>SpringerLink Journals - AutoHoldings</source><creator>Oktem, Caglar ; Aslan, Fatih ; Oktem, Ece Ozdemir</creator><creatorcontrib>Oktem, Caglar ; Aslan, Fatih ; Oktem, Ece Ozdemir</creatorcontrib><description>Background
To investigate whether unilateral late blindness alters the peripapillary retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), central macular thickness (CMT) and choroidal thickness (CT).
Methods
The 17 healthy eyes of 17 monocular patients with late blindness due to isolated eye trauma in one eye and the 19 eyes of 19 healthy individuals were evaluated in this retrospective study. Patients with at least 10 years of monocular blindness, a refractive error between + 1.5 and -1.5 D in the sighted eye, a best-corrected visual acuity of at least 20/20 and an axial length (AL) < 25 mm were included in the study. Following ophthalmologic examination, the RNFL, GCC, CMT and CT values were measured with spectral domain optic tomography (SD-OCT). Those with ocular, systemic or neurological disease that could influence the measured parameters were excluded from the study.
Results
A total of 17 (14 males, 3 females) monocular patients [mean age 41.00 ± 11.95 (24–64)] and 19 (16 males, 3 females) healthy individuals [mean age 39.79 ± 6.74 (30–56)], similar in age and gender (
p
= 0.949 and p = 0.881), were included in the study. The mean duration of being monocular was 22.76 ± 11.76 (10–49) years. No difference was present between the RNFL, GCC, CMT and CT measurements of the monocular patients and the healthy individuals (
p
= 0.692,
p
= 0.294,
p
= 0.113,
p
= 0.623, respectively). No significant correlation was found between the duration of monocularity and the retinal and optic nerve parameters.
Conclusion
The results of our study indicate no difference in the optic nerve, retina and choroid OCT findings in the sighted eyes of subjects with long-term monocular blindness compared to subjects with bilateral normal eyes. Although functional and volumetric neuroimaging studies suggest the possibility of compensation in these patients, our findings indicate that this is not at the ocular level.</description><identifier>ISSN: 0165-5701</identifier><identifier>EISSN: 1573-2630</identifier><identifier>DOI: 10.1007/s10792-021-01981-0</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Acuity ; Age ; Blindness ; Evaluation ; Eye ; Eye (anatomy) ; Females ; Males ; Medical imaging ; Medicine ; Medicine & Public Health ; Neuroimaging ; Neurological diseases ; Ophthalmology ; Optic nerve ; Original Paper ; Parameters ; Retina ; Thickness ; Trauma ; Visual acuity</subject><ispartof>International ophthalmology, 2021-12, Vol.41 (12), p.4083-4089</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2021</rights><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-3658ebd620efff6165657161577888dbb69f27cd809cc07a12a65437b18a548d3</citedby><cites>FETCH-LOGICAL-c418t-3658ebd620efff6165657161577888dbb69f27cd809cc07a12a65437b18a548d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10792-021-01981-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10792-021-01981-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids></links><search><creatorcontrib>Oktem, Caglar</creatorcontrib><creatorcontrib>Aslan, Fatih</creatorcontrib><creatorcontrib>Oktem, Ece Ozdemir</creatorcontrib><title>Evaluation of the effect of unilateral late blindness on the retina, optic nerve and choroid parameters in the sighted eye</title><title>International ophthalmology</title><addtitle>Int Ophthalmol</addtitle><description>Background
To investigate whether unilateral late blindness alters the peripapillary retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), central macular thickness (CMT) and choroidal thickness (CT).
Methods
The 17 healthy eyes of 17 monocular patients with late blindness due to isolated eye trauma in one eye and the 19 eyes of 19 healthy individuals were evaluated in this retrospective study. Patients with at least 10 years of monocular blindness, a refractive error between + 1.5 and -1.5 D in the sighted eye, a best-corrected visual acuity of at least 20/20 and an axial length (AL) < 25 mm were included in the study. Following ophthalmologic examination, the RNFL, GCC, CMT and CT values were measured with spectral domain optic tomography (SD-OCT). Those with ocular, systemic or neurological disease that could influence the measured parameters were excluded from the study.
Results
A total of 17 (14 males, 3 females) monocular patients [mean age 41.00 ± 11.95 (24–64)] and 19 (16 males, 3 females) healthy individuals [mean age 39.79 ± 6.74 (30–56)], similar in age and gender (
p
= 0.949 and p = 0.881), were included in the study. The mean duration of being monocular was 22.76 ± 11.76 (10–49) years. No difference was present between the RNFL, GCC, CMT and CT measurements of the monocular patients and the healthy individuals (
p
= 0.692,
p
= 0.294,
p
= 0.113,
p
= 0.623, respectively). No significant correlation was found between the duration of monocularity and the retinal and optic nerve parameters.
Conclusion
The results of our study indicate no difference in the optic nerve, retina and choroid OCT findings in the sighted eyes of subjects with long-term monocular blindness compared to subjects with bilateral normal eyes. Although functional and volumetric neuroimaging studies suggest the possibility of compensation in these patients, our findings indicate that this is not at the ocular level.</description><subject>Acuity</subject><subject>Age</subject><subject>Blindness</subject><subject>Evaluation</subject><subject>Eye</subject><subject>Eye (anatomy)</subject><subject>Females</subject><subject>Males</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuroimaging</subject><subject>Neurological diseases</subject><subject>Ophthalmology</subject><subject>Optic nerve</subject><subject>Original Paper</subject><subject>Parameters</subject><subject>Retina</subject><subject>Thickness</subject><subject>Trauma</subject><subject>Visual acuity</subject><issn>0165-5701</issn><issn>1573-2630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUtr3TAQhUVpobdp_kBWgm66qJORbD28DCEvCHSTrIUsj3MVfKVbSQ6kvz66caCQRTczDHznMIdDyAmDUwagzjID1fMGOGuA9brOT2TDhGobLlv4TDbApGiEAvaVfMv5CQB61csN-Xv5bOfFFh8DjRMtW6Q4TejK4VqCn23BZGd62HSYfRgD5kwrfUATFh_sLxr3xTsaMD0jtWGkbhtT9CPd22R3WB0y9asi-8dtwZHiC34nXyY7Zzx-30fk4ery_uKmuft9fXtxfte4junStFJoHEbJoT42yZpDCsVkDae01uMwyH7iyo0aeudAWcatFF2rBqat6PTYHpGfq-8-xT8L5mJ2PjucZxswLtlwIUTbSd3Jiv74gD7FJYX6XaX6rpW617xSfKVcijknnMw--Z1NL4aBOdRh1jpMrcO81WGgitpVlCscHjH9s_6P6hXB041B</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Oktem, Caglar</creator><creator>Aslan, Fatih</creator><creator>Oktem, Ece Ozdemir</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20211201</creationdate><title>Evaluation of the effect of unilateral late blindness on the retina, optic nerve and choroid parameters in the sighted eye</title><author>Oktem, Caglar ; Aslan, Fatih ; Oktem, Ece Ozdemir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-3658ebd620efff6165657161577888dbb69f27cd809cc07a12a65437b18a548d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acuity</topic><topic>Age</topic><topic>Blindness</topic><topic>Evaluation</topic><topic>Eye</topic><topic>Eye (anatomy)</topic><topic>Females</topic><topic>Males</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neuroimaging</topic><topic>Neurological diseases</topic><topic>Ophthalmology</topic><topic>Optic nerve</topic><topic>Original Paper</topic><topic>Parameters</topic><topic>Retina</topic><topic>Thickness</topic><topic>Trauma</topic><topic>Visual acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oktem, Caglar</creatorcontrib><creatorcontrib>Aslan, Fatih</creatorcontrib><creatorcontrib>Oktem, Ece Ozdemir</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oktem, Caglar</au><au>Aslan, Fatih</au><au>Oktem, Ece Ozdemir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the effect of unilateral late blindness on the retina, optic nerve and choroid parameters in the sighted eye</atitle><jtitle>International ophthalmology</jtitle><stitle>Int Ophthalmol</stitle><date>2021-12-01</date><risdate>2021</risdate><volume>41</volume><issue>12</issue><spage>4083</spage><epage>4089</epage><pages>4083-4089</pages><issn>0165-5701</issn><eissn>1573-2630</eissn><abstract>Background
To investigate whether unilateral late blindness alters the peripapillary retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), central macular thickness (CMT) and choroidal thickness (CT).
Methods
The 17 healthy eyes of 17 monocular patients with late blindness due to isolated eye trauma in one eye and the 19 eyes of 19 healthy individuals were evaluated in this retrospective study. Patients with at least 10 years of monocular blindness, a refractive error between + 1.5 and -1.5 D in the sighted eye, a best-corrected visual acuity of at least 20/20 and an axial length (AL) < 25 mm were included in the study. Following ophthalmologic examination, the RNFL, GCC, CMT and CT values were measured with spectral domain optic tomography (SD-OCT). Those with ocular, systemic or neurological disease that could influence the measured parameters were excluded from the study.
Results
A total of 17 (14 males, 3 females) monocular patients [mean age 41.00 ± 11.95 (24–64)] and 19 (16 males, 3 females) healthy individuals [mean age 39.79 ± 6.74 (30–56)], similar in age and gender (
p
= 0.949 and p = 0.881), were included in the study. The mean duration of being monocular was 22.76 ± 11.76 (10–49) years. No difference was present between the RNFL, GCC, CMT and CT measurements of the monocular patients and the healthy individuals (
p
= 0.692,
p
= 0.294,
p
= 0.113,
p
= 0.623, respectively). No significant correlation was found between the duration of monocularity and the retinal and optic nerve parameters.
Conclusion
The results of our study indicate no difference in the optic nerve, retina and choroid OCT findings in the sighted eyes of subjects with long-term monocular blindness compared to subjects with bilateral normal eyes. Although functional and volumetric neuroimaging studies suggest the possibility of compensation in these patients, our findings indicate that this is not at the ocular level.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s10792-021-01981-0</doi><tpages>7</tpages></addata></record> |
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| subjects | Acuity Age Blindness Evaluation Eye Eye (anatomy) Females Males Medical imaging Medicine Medicine & Public Health Neuroimaging Neurological diseases Ophthalmology Optic nerve Original Paper Parameters Retina Thickness Trauma Visual acuity |
| title | Evaluation of the effect of unilateral late blindness on the retina, optic nerve and choroid parameters in the sighted eye |
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