Differential redox proteomic profiles of serum from severe asthma patients after one month of benralizumab and mepolizumab treatment
Mepolizumab and Benralizumab are biological drugs for severe asthma patients able to reduce moderate-to-severe exacerbation rate (peripheral eosinophilial % mepolizumab 1.6 ± 1.2; benralizumab 0; p
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| Veröffentlicht in: | Pulmonary pharmacology & therapeutics 2021-10, Vol.70, p.102060-102060, Article 102060 |
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| container_title | Pulmonary pharmacology & therapeutics |
| container_volume | 70 |
| creator | Landi, C. Vantaggiato, L. Shaba, E. Cameli, P. Carleo, A. d’Alessandro, M. Bergantini, L. Bargagli, E. Bini, L. |
| description | Mepolizumab and Benralizumab are biological drugs for severe asthma patients able to reduce moderate-to-severe exacerbation rate (peripheral eosinophilial % mepolizumab 1.6 ± 1.2; benralizumab 0; p |
| doi_str_mv | 10.1016/j.pupt.2021.102060 |
| format | Article |
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Our results highlighted apolipoprotein A1 oxidation after Mepolizumab treatment, that could be related to HDL functionality and could represent a potential biomarker for the treatment. On the other hand, after one month of Benralizumab we detected higher oxidation levels of ceruloplasmin and transthyretin, considered an important oxidative stress biomarker which action help to maintain redox homeostasis.
•Mepolizumab and Benralizumab are biological drugs for severe asthma disease.•We report a preliminary redox proteomic study of serum before and after 1 month of benralizumab and mepolizumab treatment.•APOAI oxidation could represent a biomarker for mepolizumab treatment.•Ceruloplasmin and transthyretin are considered important oxidative stress biomarkers for benralizumab treatment.</description><identifier>ISSN: 1094-5539</identifier><identifier>EISSN: 1522-9629</identifier><identifier>DOI: 10.1016/j.pupt.2021.102060</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>Benralizumab ; Mepolizumab ; Redox proteomics ; Serum ; Severe eosinophilic asthma</subject><ispartof>Pulmonary pharmacology & therapeutics, 2021-10, Vol.70, p.102060-102060, Article 102060</ispartof><rights>2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c333t-8008dd2dcf87afb837e5ce30d06d7bec1debbd99ad0e95127122b9cee05288c3</citedby><cites>FETCH-LOGICAL-c333t-8008dd2dcf87afb837e5ce30d06d7bec1debbd99ad0e95127122b9cee05288c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1094553921000729$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids></links><search><creatorcontrib>Landi, C.</creatorcontrib><creatorcontrib>Vantaggiato, L.</creatorcontrib><creatorcontrib>Shaba, E.</creatorcontrib><creatorcontrib>Cameli, P.</creatorcontrib><creatorcontrib>Carleo, A.</creatorcontrib><creatorcontrib>d’Alessandro, M.</creatorcontrib><creatorcontrib>Bergantini, L.</creatorcontrib><creatorcontrib>Bargagli, E.</creatorcontrib><creatorcontrib>Bini, L.</creatorcontrib><title>Differential redox proteomic profiles of serum from severe asthma patients after one month of benralizumab and mepolizumab treatment</title><title>Pulmonary pharmacology & therapeutics</title><description>Mepolizumab and Benralizumab are biological drugs for severe asthma patients able to reduce moderate-to-severe exacerbation rate (peripheral eosinophilial % mepolizumab 1.6 ± 1.2; benralizumab 0; p < 0.0001), improving the quality of life and lung function parameters (FEV1%: mepolizumab 87.1 ± 21.5; benralizumab 89.7 ± 15, p < 0.04). Here we report a preliminary redox proteomic study highlighting the level of oxidative burst present in serum from patients before and after one month of both treatments.
Our results highlighted apolipoprotein A1 oxidation after Mepolizumab treatment, that could be related to HDL functionality and could represent a potential biomarker for the treatment. On the other hand, after one month of Benralizumab we detected higher oxidation levels of ceruloplasmin and transthyretin, considered an important oxidative stress biomarker which action help to maintain redox homeostasis.
•Mepolizumab and Benralizumab are biological drugs for severe asthma disease.•We report a preliminary redox proteomic study of serum before and after 1 month of benralizumab and mepolizumab treatment.•APOAI oxidation could represent a biomarker for mepolizumab treatment.•Ceruloplasmin and transthyretin are considered important oxidative stress biomarkers for benralizumab treatment.</description><subject>Benralizumab</subject><subject>Mepolizumab</subject><subject>Redox proteomics</subject><subject>Serum</subject><subject>Severe eosinophilic asthma</subject><issn>1094-5539</issn><issn>1522-9629</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kD1PwzAQhiMEEqXwB5g8sqT4o24SiQWVT6kSS3fLsc-qqzgOtlMBMz8cR4WV6d473XPSPUVxTfCCYLK63S-GcUgLiinJA4pX-KSYEU5p2axoc5ozbpYl56w5Ly5i3GOMqyXjs-L7wRoDAfpkZYcCaP-BhuATeGfVlIztICJvUIQwOmSCdzkeMoJkTDsn0SCTzXxE0iQIyPeAnO_TboJa6IPs7NfoZItkr5GDwf_1KYBMLqOXxZmRXYSr3zovtk-P2_VLuXl7fl3fb0rFGEtljXGtNdXK1JU0bc0q4AoY1nilqxYU0dC2ummkxtBwQitCadsoAMxpXSs2L26OZ_Nb7yPEJJyNCrpO9uDHKCjPghhnS55X6XFVBR9jACOGYJ0Mn4JgMRkXezEZF5NxcTSeobsjBPmHg4UgospmFGgbQCWhvf0P_wEbgI50</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Landi, C.</creator><creator>Vantaggiato, L.</creator><creator>Shaba, E.</creator><creator>Cameli, P.</creator><creator>Carleo, A.</creator><creator>d’Alessandro, M.</creator><creator>Bergantini, L.</creator><creator>Bargagli, E.</creator><creator>Bini, L.</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202110</creationdate><title>Differential redox proteomic profiles of serum from severe asthma patients after one month of benralizumab and mepolizumab treatment</title><author>Landi, C. ; Vantaggiato, L. ; Shaba, E. ; Cameli, P. ; Carleo, A. ; d’Alessandro, M. ; Bergantini, L. ; Bargagli, E. ; Bini, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c333t-8008dd2dcf87afb837e5ce30d06d7bec1debbd99ad0e95127122b9cee05288c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Benralizumab</topic><topic>Mepolizumab</topic><topic>Redox proteomics</topic><topic>Serum</topic><topic>Severe eosinophilic asthma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Landi, C.</creatorcontrib><creatorcontrib>Vantaggiato, L.</creatorcontrib><creatorcontrib>Shaba, E.</creatorcontrib><creatorcontrib>Cameli, P.</creatorcontrib><creatorcontrib>Carleo, A.</creatorcontrib><creatorcontrib>d’Alessandro, M.</creatorcontrib><creatorcontrib>Bergantini, L.</creatorcontrib><creatorcontrib>Bargagli, E.</creatorcontrib><creatorcontrib>Bini, L.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pulmonary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Landi, C.</au><au>Vantaggiato, L.</au><au>Shaba, E.</au><au>Cameli, P.</au><au>Carleo, A.</au><au>d’Alessandro, M.</au><au>Bergantini, L.</au><au>Bargagli, E.</au><au>Bini, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential redox proteomic profiles of serum from severe asthma patients after one month of benralizumab and mepolizumab treatment</atitle><jtitle>Pulmonary pharmacology & therapeutics</jtitle><date>2021-10</date><risdate>2021</risdate><volume>70</volume><spage>102060</spage><epage>102060</epage><pages>102060-102060</pages><artnum>102060</artnum><issn>1094-5539</issn><eissn>1522-9629</eissn><abstract>Mepolizumab and Benralizumab are biological drugs for severe asthma patients able to reduce moderate-to-severe exacerbation rate (peripheral eosinophilial % mepolizumab 1.6 ± 1.2; benralizumab 0; p < 0.0001), improving the quality of life and lung function parameters (FEV1%: mepolizumab 87.1 ± 21.5; benralizumab 89.7 ± 15, p < 0.04). Here we report a preliminary redox proteomic study highlighting the level of oxidative burst present in serum from patients before and after one month of both treatments.
Our results highlighted apolipoprotein A1 oxidation after Mepolizumab treatment, that could be related to HDL functionality and could represent a potential biomarker for the treatment. On the other hand, after one month of Benralizumab we detected higher oxidation levels of ceruloplasmin and transthyretin, considered an important oxidative stress biomarker which action help to maintain redox homeostasis.
•Mepolizumab and Benralizumab are biological drugs for severe asthma disease.•We report a preliminary redox proteomic study of serum before and after 1 month of benralizumab and mepolizumab treatment.•APOAI oxidation could represent a biomarker for mepolizumab treatment.•Ceruloplasmin and transthyretin are considered important oxidative stress biomarkers for benralizumab treatment.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.pupt.2021.102060</doi><tpages>1</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Benralizumab Mepolizumab Redox proteomics Serum Severe eosinophilic asthma |
| title | Differential redox proteomic profiles of serum from severe asthma patients after one month of benralizumab and mepolizumab treatment |
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