Insulin signaling pathway assessment by enhancing antioxidant activity due to morin using in vitro rat skeletal muscle L6 myotubes cells

Background Plant-derived phytochemicals such as flavonoids have been explored to be powerful antioxidants that protect against oxidative stress-related diseases. In the present study, Morin, a flavonoid compound was studied for its antioxidant and antidiabetic properties in relation to oxidative str...

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Veröffentlicht in:	Molecular biology reports 2021-08, Vol.48 (8), p.5857-5872
Hauptverfasser:	Issac, Praveen Kumar, Karan, Rupmanjari, Guru, Ajay, Pachaiappan, R., Arasu, Mariadhas Valan, Al-Dhabi, Naif Abdullah, Choi, Ki Choon, Harikrishnan, Ramasamy, Raj, Jesu Arockia
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Animal Anatomy Animal Biochemistry Animal models Animals Antidiabetics Antioxidants Antioxidants - pharmacology Biomedical and Life Sciences Cell Line Cell Survival - drug effects Cell viability Cytotoxicity Diabetes mellitus Flavonoids Flavonoids - metabolism Flavonoids - pharmacology Gene expression Genistein Glucose Glucose - metabolism Glycogen Glycogen - metabolism Glycogen Synthase Kinase 3 beta - metabolism Histology Hypoglycemic Agents - pharmacology Insulin Insulin - metabolism Insulin receptor substrate 1 Insulin resistance Insulin Resistance - physiology Life Sciences Morphology Muscle Fibers, Skeletal - metabolism Muscle, Skeletal - metabolism Musculoskeletal system Myoblasts - metabolism Myotubes Original Article Oxidants Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Phosphatidylinositol 3-Kinases - metabolism Plant cells Plants Polymerase chain reaction Rats Reactive oxygen species Reactive Oxygen Species - metabolism Signal transduction Signal Transduction - drug effects Skeletal muscle Wortmannin
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