Recent advances in the role of Th17/Treg cells in tumor immunity and tumor therapy
Th17 and Treg cells play an important role in regulating tissue inflammation and maintaining the stability of the immune system. They regulate inflammatory responses, participate in the occurrence and development of autoimmune diseases and tumors, and determine the disease progress. Malignant tumor...
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| Veröffentlicht in: | Immunologic research 2021-10, Vol.69 (5), p.398-414 |
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| creator | Qianmei, Yin Zehong, Su Guang, Wang Hui, Li Lian, Gaojian |
| description | Th17 and Treg cells play an important role in regulating tissue inflammation and maintaining the stability of the immune system. They regulate inflammatory responses, participate in the occurrence and development of autoimmune diseases and tumors, and determine the disease progress. Malignant tumor is one of the diseases with the highest mortality rate in the world. However, the efficacy of traditional treatment is limited, so it is necessary to find safe and efficient treatment methods. Studies have shown that the balance of Th17/Treg cells plays a critical role in tumor progression. In this paper, we review the antitumor and tumor-suppressing effects of Th17/Treg cells, and new strategies for tumor therapy, combined with new research hotspots such as immune checkpoint therapy, miRNA-related gene therapy, and metabolic pathway regulation of Th17/Treg cell differentiation and tumor generation. The synergistic therapy is expected to be widely used in the future clinical practice, providing a new choice for the prevention and treatment of malignant tumors. |
| doi_str_mv | 10.1007/s12026-021-09211-6 |
| format | Article |
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Academic</collection><jtitle>Immunologic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qianmei, Yin</au><au>Zehong, Su</au><au>Guang, Wang</au><au>Hui, Li</au><au>Lian, Gaojian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recent advances in the role of Th17/Treg cells in tumor immunity and tumor therapy</atitle><jtitle>Immunologic research</jtitle><stitle>Immunol Res</stitle><addtitle>Immunol Res</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>69</volume><issue>5</issue><spage>398</spage><epage>414</epage><pages>398-414</pages><issn>0257-277X</issn><eissn>1559-0755</eissn><abstract>Th17 and Treg cells play an important role in regulating tissue inflammation and maintaining the stability of the immune system. They regulate inflammatory responses, participate in the occurrence and development of autoimmune diseases and tumors, and determine the disease progress. Malignant tumor is one of the diseases with the highest mortality rate in the world. However, the efficacy of traditional treatment is limited, so it is necessary to find safe and efficient treatment methods. Studies have shown that the balance of Th17/Treg cells plays a critical role in tumor progression. In this paper, we review the antitumor and tumor-suppressing effects of Th17/Treg cells, and new strategies for tumor therapy, combined with new research hotspots such as immune checkpoint therapy, miRNA-related gene therapy, and metabolic pathway regulation of Th17/Treg cell differentiation and tumor generation. 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| ispartof | Immunologic research, 2021-10, Vol.69 (5), p.398-414 |
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| subjects | Allergology Animals Anticancer properties Antitumor activity Autoimmune diseases Biomarkers Biomedical and Life Sciences Biomedicine Cancer therapies Cell Communication - genetics Cell Communication - immunology Cell differentiation Cell Plasticity - immunology Combined Modality Therapy Differentiation (biology) Disease Management Disease Susceptibility - immunology Gene therapy Health services Helper cells Humans Immune checkpoint Immune system Immunology Inflammation Internal Medicine Lymphocyte Activation - genetics Lymphocyte Activation - immunology Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Lymphocytes, Tumor-Infiltrating - pathology Medicine/Public Health Metabolic pathways miRNA Neoplasms - diagnosis Neoplasms - etiology Neoplasms - metabolism Neoplasms - therapy Review T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - pathology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Th17 Cells - immunology Th17 Cells - metabolism Treatment Outcome Tumor Microenvironment - immunology Tumors |
| title | Recent advances in the role of Th17/Treg cells in tumor immunity and tumor therapy |
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